The End of HIV: Vaccine Aces Clinical Tests

HIV_virusThe news that Caltech was developing a potential vaccine for HIV was considered one the biggest stories of 2012. And now, less than a year later, researchers at the Schulich School of Medicine & Dentistry at Western University in London, Ontario have announced that the vaccine not only passed its first round of clinical testing, but even boosted the production of antibodies in patients it was tested on.

The SAV001 vaccine is one of only a handful of HIV vaccines in the world, and is based on a genetically-modified ‘dead’ version of the virus. U.S. clinical testing began in the in March 2012, looking at HIV-infected men and women between the ages of 18 and 50. Half the target group was administered a placebo, while the other group was given SAV001. The first phase of trials wrapped up last month, with researchers optimistic about the vaccine’s future.

HIV_vaccine_westernDr. Chil-Yong Kang, a professor of microbiology and immunology and the head of the Western research team, explained the process in a recent interview with the Ontario Business Report:

We infect the cells with a genetically modified HIV-1. The infected cells produce lots of virus, which we collect, purify and inactivate so that the vaccine won’t cause AIDS in recipients, but will trigger immune responses.

This is the reverse of what researchers at Caltech did, who relied on a technique known as Vectored ImmunoProphylaxis (VIP) to stimulate antibody formation in lab mice. Here too, the researchers received immensely positive results. After introducing up 100 times the amount of HIV virus that what would be required to cause infection,  the mice remained protected.

vaccineBy demonstrating that not one, but two different methods of preventing the spread of HIV are effective, we could be looking at turning point in the war on HIV/AIDS. The only question is, when will a vaccine be commercially available? According to Sumagen, the South Korean biotech firm sponsoring the creation vaccine, manufacturing, as well as the USFDA requirements and other bureaucratic hurdles remain to contend with.

But, if all goes well with future trials, it could be commercially available in as little as five years. As CEO Jung-Gee Cho said in a press release:

We are now prepared to take the next steps towards Phase II and Phase III clinical trials. We are opening the gate to pharmaceutical companies, government, and charity organization for collaboration to be one step closer to the first commercialized HIV vaccine.

Paired with a possible cure which relies on nanoparticles and bee venom, we could even be looking at the beginning of the end of the pandemic, one which has caused between 25 and 30 million deaths worldwide since its discovery in 1981.

And in the meantime, check out this interview of Dr. Chil-Yong Kang as he explains how he and his research team developed their HIV vaccine, courtesy of the CHIR Canadian HIV Trial Network:

Sources: huffingtonpost.ca, mri.gov.on.ca, aids.gov, unaids.org

 

NASA: The World Will Not End on Dec. 21st, 2012

Worlds CollidingIt seems NASA spends untold resources trying to debunk conspiracy theories and doomsday predictions. Sad, when you consider all the wonderful uses this time and energy could be dedicated towards, like putting people on Mars! In any case, and in anticipation for this coming Friday (and Saturday, if all goes well!), I thought I’d share this video NASA released to put people’s minds at ease. The world will NOT end on Dec. 21st, 2012, it claims, and presents the scientific findings that say so.

Set on Dec. 22nd, 2012, the video approaches the apocalypse as if it is something that has already come and gone and proceeds to explain how the myth of the 2012 End of the World scenario began in the first place. In examining the actual Mayan Calendar, the reasons for why the calendar ends when it does, and taking a look at all the stellar and terrestrial phenomena which are believed to coincide with the date (but which won’t), NASA shows why we have nothing to worry about.

In fact, if anything, the date in question will be a time of rejoicing. Not only is it the holiday season for people worldwide, it is also the natural turning point in the Mayan Calendar, the date at which the ancient astronomers reckoning of time would “reset” in accordance with their ancient theology. This was a regular pattern as far as the Yucatan-based civilization was concerned, and is a testament to their long and expansive concepts of time and cosmology.

Nothing destructive was ever mentioned or implied in the Mayan belief system, merely a rolling over of the odometer and an entrance into a new age. If anything, it was western apocalyptics and cultists, with their preconceived notions of the End of Days and astrology, that attached this significance to the date. Astrological phenomena, such a meteor striking Earth, an inversion of our gravitational field, a massive solar flare, or another planet colliding with us, were all added as a means of explaining how. But, as the experts as NASA show, none of this stuff is happening or in danger of happening in the next few days.

In short, we can all look forward to another holiday season with plenty of food, family, in-laws and swag. As my grandpa used to say “the sun will still rise in the east and set in the west”, the world will keep on spinning, and people will keep on waiting for the end of the days to come. Fear not the End of Days, fear waking up tomorrow and realizing that you still have to get up, go to your job, and tolerate all the little annoyances we all deal with on a daily basis. And while your at it, be thankful you’re alive and STOP WISHING FOR IT ALL TO END!

And if that is still not enough to convince the doomsayers that life will go on, perhaps a quick look at their track record will be enough to convince the rest of us of how often they are wrong. Consider…

30-36 – 2012 C.E: After the death of Jesus and the spread of early Christianity, believers begin to prepare for the “coming of the Lord”. After several centuries, it is clear that the End of Days isn’t just around the corner, so believers begin to settle in and create Monasteries in the hopes of living how the Savior would have wanted. Two-thousand years later, we’re all still waiting!

410 C.E.: Rome is sacked, leading many Christians to fear that the Barbarian hordes are the harbingers of the Apocalypse. However, St. Augustine of Hippo allays much of these fears with his book City of God, where he states that though the corporeal capital of Christianity may have been sacked, the city of God abides. People promptly calm down…

900 C.E.: The fall of the Western Roman Empire leads to renewed fears that the world is ending. However, despite the decline in education, wealth, central leadership, life expectancy, and an upsurge in violence, life goes on…

1000 C.E.: Europe becomes consumed by apocalyptic predictions with the coming of the Millennium. On Dec. 31st, 999, nothing happens! The sun rises on the following day and people go back about their business…

1206-1294 C.E.: The Mongol Hordes, a vast and terrible army, reach Europe from Asia and begin a campaign of conquest and slaughter. People everywhere believe they are the Four Horsemen of the Apocalypse foretold in the Book of Revelation. However, Mongol expansion soon ceases, the Empire is subdivided amongst Ghengis Khan’s sons and vassals, and life continues. Just another Horde from the East that failed to deliver on the Apocalypse I guess!

1348-1350 C.E.: The Black Death strikes Europe. People everywhere believe this is God’s judgement and the Rapture is sure to follow. Flagellants punish themselves for the good of humanity, witches are burned, Jews are murdered, cats hung, and any and all traces of “wicked behavior” and people are scapegoated and purged. However, within two years, the plague passes, one-third of Europe has died, but life goes on and a period of rapid recovery soon follows.

1914 C.E.: The outbreak of the Great War leads many to believe that Armaggedon, the last great battle that will signal the end of time, is upon them! After four years of brutal, protracted warfare, all sides agree to a ceasefire and previously held romantic notions of warfare are shattered. Henceforth, Remembrance Day, Veteran’s Day, Memorial Day, and a series of other national and international holidays mark the occasion and remind us how foolish and horrible war really is. However, the world does not end…

1918 C.E.: “Red October” shakes the world, with many predicting that the victory by the “Godless Communists” is a sign of the Apocalypse. However, despite the terrible crimes that follow in the Marxist-Leninists wake, especially where Joseph Stalin, Mao Zedong and Pol Pot are concerned, the world keeps on spinning, even after the conflict becomes nuclear in scope (see next).

1945  – 1991 C.E.: The advent of nuclear weapons and the beginning of the Cold War lead to a resurgence in Apocalyptic predictions, with many claiming that “The End is Near” on a regular basis. However, numerous close shaves pass without incident, the Cold War ends by 1991, and all predictions as to how “Nuclear Holocaust” will take place fail to be realized. In the end, many people realize that the human race isn’t suicidal or quite as stupid as previously thought. Others continue to ponder how WWIII will happen, but produce no realistic scenarios.

1948 C.E. – : The Arab-Israeli Conflict begins and escalates with such events as the Suez Crisis (1956), the Six Day War (1967), and Yom Kipper (1973). Religious scholars and believers begin to claim that these events were foretold in Scripture, and foretell of the coming battle of Armageddon – which will take place at Tel Meggido in modern day Israel. However, land for peace and a detente have prevented any full-scale wars since 1973, and the Oslo Accords of 1992 seem to suggest that a permanent peace between Israel and the Palestinians is just a matter of time.

1980’s C.E.: The growing awareness of the AIDS virus prompts many religious nuts and homophobes to claim that “Gods Judgement is Here” and is taking the form of a virus that strikes down sinners. However, public education and about thirty years with no Rapture lead most to conclude that this is a terrible disease which merits no religious condemnation. Public decrying of victims remains, but few people take them seriously.

1994/5 C.E.: Renewed outbreaks of the Ebola virus leads to new fears of a global pandemic. Movies like The Stand, Outbreak and just about any scenario involving biological warfare do great at the box office, but the apocalyptic nightmare never comes true. And when people realize that casualties are largely reserved to African nations, they generally stop caring!

1990 – 2000 C.E.: Y2K histeria sets in as people get wind of a possible bug that could shut down the world’s computers. People begin hoarding and stocking their shelves in preparation for the pandemonium and chaos that is expected. When the clock strikes midnight of Dec. 31st 1999, nothing happens! The world keeps spinning, the computers keep working, and the nuts go looking for another reason to panic. There are still plenty to choose from…

And let’s not forget 9/11, Hurricane Katrina, the Bath Salts Zombies and every other major disaster that has befallen the world in recent years. Seems every day weirdos and nutjobs are finding reasons to think we’re all going to die. One would think they wanted it to happen or something…

In the meantime, enjoy the video and all its sane and sensible points!

Source: Nasa.org, gaurdian.co.uk