The Future is Here: Weight-Controlling Implants

genetic_circuitObesity is one of the greatest epidemics effecting children in the developed world, resulting in billions spent annually on fad diets, miracle foods, and exercise programs. But researchers ETH-Zurich have come up with a potential high-tech solution to the problem. It consists of an implant that monitors fat in the blood and, in response to elevated levels, it produces a substance that tells the body that it’s not hungry.

The method relies on a “genetic circuit”, a component that perform logical operations in living cells. Originally developed by Boston University biomedical engineers Ahmad S. Khalil and James J. Collins, the regulatory circuit is put together using mostly biological components. These consisted of several genes that generate particular proteins and reactions. This compound was inserted into tiny capsules.

weight_control_implantThe circuit essentially performs two functions: monitoring the circulating fat levels in the blood, and then, in the event of detecting excess levels, produces a messenger substance that conveys a cognitive response that tells the user they are full and sated. For the sake of the experiment, the mice were continually given high-fat foods. As ETH-Zurich professor Martin Fussenegger explained in a statement:

Instead of placing the mice on a diet to achieve weight loss, we kept giving the animals as much high-calorie food as they could eat.

The implants responded as expected, causing the obese mice to stop their excessive eating, and their bodyweight dropped noticeably as a result. Once their blood-fat levels returned to normal, the implant stopped producing the fullness signal. As for the control group, mice that received normal animal feed with a 5% fat content did not lose any weight or reduce their intake of food.

?????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????Interestingly, the sensor can also detect different types of fat, including saturated and unsaturated animal and vegetable fats — even when they’re all ingested at the same time. This allows people to continue to take in the kinds of fats their bodies depend upon – such as Omega fatty acids and unsaturated fats – while limiting their intake of saturated fat, something we as a society get far too much of.

But of course, there are challenges in adapting this technology for human used. The researchers caution that it will take several more years to develop an implant that do the same job for the human body. But given the exponential rate of development with medical and health-monitoring implants, we can expect to be seeing a full range of weight-control or even diet-specific and allergen-detecting implants before long.

genetic_circuit_MITIn addition to weight loss, this and other breakthroughs like it could facilitate the development of artificial cells designed to solve problems in medicine, energy, and the environment. It’s also a major step towards an age where people are able to manipulate their own biochemistry, and the building blocks of nature, at a microscopic level. Another step forward towards the nanotechnological revolution!

Sources: IO9.com, (2)

News From Space: We Come From Mars!

Mars_Earth_Comparison-580x356Men are from Mars, women are… also from Mars? That is the controversial theory that was proposed yesterday at the annual Goldschmidt Conference of geochemists being held in Florence, Italy. The proposal was made by Professor Steven Benner of the Westheimer Institute of Science and Technology in Florida and is the result of new evidence uncovered by his research team.

The theory that life on Earth originated on Mars has been argued before, but has remained contentious amongst the scientific community. However, Benner claims that new evidence supports the conclusion that the Red Planet really is our ancestral home by demonstrating that the elements for life here could only form on Mars, and came here via a Martian meteorite.

Asteroid-Impacts-MarsAccording to the theory, rocks violently flung up from the Red Planet’s surface during mammoth collisions with asteroids or comets then traveled millions of kilometers across interplanetary space to Earth. Once they reached Earth’s atmosphere. they melted, heated and exploded violently before the remnants crashed into the solid or liquid surface.

All that would be needed is for a few of those space born rocks to contain microbes from Mars surface. These building blocks of life would have to survive the journey through space and the impact on Earth to make this happen. But research into Exogenesis – the possibility that life was transplanted on Earth by meteorites – has already shown that this is possible.

curiosity_sol-177-1What’s more, NASA’s Curiosity Rover was expressly created to search for the the environmental conditions that would support life. Less than half a year into its mission it accomplished just that, locating proof of the existence of water and a habitable zone. Between it and the Opportunity Rover, the search to determine if life still exists – in the form of organic molecules – continues and is expected to yield results very soon.

But of course, Benner was quick to point out that there is a difference between habitability (i.e. where can life live) and origins (where might life have originated). The presence organic molecules alone is not enough when it comes to the mystery of life’s creation, and when it comes to making the great leap between having the necessarily elements and the existence of living organisms, scientists remain hung up on two paradoxes.

These are known as the tar paradox and the water paradox, respectively. The former paradox addresses how life as we know it comes down to the presence of organic molecules, which are produced by the chemistry of carbon and its compounds. However, the presence of these compounds does not ensure the creation of life, and laboratory experiments to combine and heat them has only ever produced tar.

mars_lifeAs he puts it, the origin of life involves “deserts” and oxidized forms of the elements Boron (B) and Molybdenum (Mo) – namely borate and molybdate. Essentially, these elements are the difference between the formation of tar and RNA, the very building block of life:

Certain elements seem able to control the propensity of organic materials to turn into tar, particularly boron and molybdenum, so we believe that minerals containing both were fundamental to life first starting. Analysis of a Martian meteorite recently showed that there was boron on Mars; we now believe that the oxidized form of molybdenum was there too.

The second paradox relates to water, which is believed to be intrinsic for life to flourish, but can be also hazardous to its formation. According to modern research, RNA forms prebiotically, requiring mineral species like borate to capture organic elements before they devolve into tar and molybdate to arrange the material to give it ribose – organic sugars, also intrinsic to life.

Mars-snow-header-640x353This can only occur in deserts, he claims, because water is detrimental to RNA and inhibits the formation of borates and molybdates. And from a geological standpoint, there was simply too much water covering the early Earth’s surface to allow for this creation process to take place:

[W]ater is corrosive to RNA, which scientists believe was the first genetic molecule to appear. Although there was water on Mars, it covered much smaller areas than on early Earth. Various geologists will not let us have these [borates and molybdates] on early Earth, but they will let us have them on Mars. So IF you believe what the geologists are telling you about the structure of early Earth, AND you think that you need our chemistry to get RNA, AND IF you think that life began with RNA, THEN you place life’s origins on Mars,

All of this has served to throw the previously-held theory – that life came to Earth through water, minerals and organics being transported by comets – into disarray. Based on this new theory, comets are a bad candidate for organic life since they lack the hot, dry conditions for borate and molybdate formation.

Living-Mars.2If the new theory is to be believed, Mars boasted the proper conditions to create the elements for life, while Earth possessed the water to help it flourish. If such a partnership is needed for the creation of organic life, then scientists will need to reevaluate the likelihood of finding it elsewhere in the universe. Between the existence of water and hot dry environments, life would seem to require more specialized conditions than previously though.

But of course, the debate on whether Earthlings are really Martians will continue as scientific research progresses and definitive proof is discovered and accepted by the majority of the scientific community. In the meantime, Curiosity is expected to rendezvous with Mount Sharp sometime next spring or summer, where it will determine if organic molecules and elements like Boron and Molybdenum exist there.

And on Nov. 18th, NASA will launch its next mission to Mars – the MAVEN orbiter – which will begin studying the upper Martian atmosphere for the first time, determining its previous composition, and where all the water went and when was it lost. So we can expect plenty more news to come to us from our neighboring Red Planet. Wait and see!

Source: universetoday.com