Tag: reconstructive surgery

The Future of Medicine: Replacement Ears and “Mini Hearts”

biomedicineBiomedicine is doing some amazing things these days, so much so that I can hardly keep up with the rate of developments. Just last month, two amazing ones were made, offering new solutions for replacing human tissue and treating chronic conditions. The first has to do with a new method of growing human using a patients own DNA, while the second involves using a patient’s own heart tissue to create “mini hearts” to aid in circulation.

The first comes from London’s Great Ormond Street Hospital, where researchers are working on a process that will grow human ears using genetic material taken from a patient’s own fat tissue. Building upon recent strides made in the field of bioprinting, this process will revolution reconstructive surgery as we know it. It also seeks to bring change to an area of medicine which, despite being essential for accident victims, has been sadly lacking in development.

replacement_earCurrently, the procedure to repair damaged or non-existent cartilage in the ear involves an operation that is usually carried out when the patient is a child. For the sake of this procedure, cartilage is extracted from the patient’s ribs and painstakingly crafted into the form of an ear before being grafted back onto the individual. Whilst this method of reconstruction achieves good results, it also comes with its share of unpleasant side effects.

Basically, the patient is left with a permanent defect around the area from where the cells were harvested, as the cartilage between the ribs does not regenerate. In this new technique, the cartilage cells are engineered from mesenchymal stem cells, extracted from the child’s abdominal adipose (fat) tissue. The benefit of this new system is that unlike the cartilage in the ribs, the adipose tissue regenerates, therefore leaving no long-term defect to the host.

stem_cells1There is also the potential to begin reconstructive treatment with stem cells derived from adipose tissue earlier than previously possible, as it takes time for the ribs to grow enough cartilage to undergo the procedure. As Dr. Patrizia Ferretti, a researcher working on the project, said in a recent interview:

One of the main benefits in using the patient’s own stem cells is that there is no need for immune suppression which would not be desirable for a sick child, and would reduce the number of severe procedures a child needs to undergo.

To create the form of the ear, a porous polymer nano-scaffold is placed in with the stem cells. The cells are then chemically induced to become chondrocytes (aka. cartilage cells) while growing into the holes in the scaffold to create the shape of the ear. According to Dr. Ferretti, cellularized scaffolds – themselves a recent medical breakthrough – are much better at integrating than fully-synthetic implants, which are more prone to extrusion and infection.

cartilage2Dr. Ferretti continued that:

While we are developing this approach with children with ear defects in mind, it could ultimately be utilized in other types of reconstructive surgery both in children and adults.

Basically, this new, and potentially more advantageous technique would replace the current set of procedures in the treatment of defects in cartilage in children such as microtia, a condition which prevents the ear from forming correctly. At the same time, the reconstructive technology also has the potential to be invaluable in improving the quality of life of those who have been involved in a disfiguring accident or even those injured in the line of service.

mini_hearts`Next up, there is the “mini heart” created by Dr. Narine Sarvazyan of George Washington University in Washington D.C.. Designed to be wrapped around individual veins, these cuffs of rhythmically-contracting heart tissue are a proposed solution to the problem of chronic venous insufficiency – a condition where leg veins suffer from faulty valves, which prevents oxygen-poor blood from being pumped back to the heart.

Much like process for creating replacement ears, the mini hearts are grown  by coaxing a patient’s own adult stem cells into becoming cardiac cells. When one of those cuffs is placed around a vein, its contractions aid in the unidirectional flow of blood, plus it helps keep the vein from becoming distended. Additionally, because it’s grown from the patient’s own cells, there’s little chance of rejection. So far, the cuffs have been grown in the lab, where they’ve also been tested. But soon, Sarvazyan hopes to conduct animal trials.

mini_hearts2As Sarvazyan explained, the applications here far beyond treating venous insufficiency. In addition, there are the long-range possibilities for organ replacement:

We are suggesting, for the first time, to use stem cells to create, rather than just repair damaged organs. We can make a new heart outside of one’s own heart, and by placing it in the lower extremities, significantly improve venous blood flow.

One of the greatest advantages of the coming age of biomedicine is the ability to replace human limbs, organs and tissue using organic substitutions. And the ability to grow these from the patient’s own tissue is a major plus, in that it cuts down on the development process and ensures a minimal risk of rejection. On top of all that, the ability to create replacement organs would also significantly cut down on the costs of replacement tissue, as well as the long waiting periods associated with donor lists.

Imagine that, if you will. A future where a patient suffering from liver, kidney, circulatory, or heart problems is able to simply visit their local hospital or clinic, donate a meager supply of tissue, and receive a healthy, fully-compatible replacement after an intervening period (days or maybe even hours). The words “healthy living” will achieve new meaning!

 

Sources: gizmag.com, (2), nanomedjournal.com

More Top Stories of 2012

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With 2012 now officially behind us, and more and more stories trickling into this humble bloggers account about what was accomplished therein, it seems that the time is ripe for another list of breakthroughs, first, and achievements that made the news during the previous year!

Last time, I listed what I saw as the top 12, only to find that there were several others, some of which I actually wrote about, that didn’t make the cut. How foolish of me! And so, to remedy this and possibly cover stories that I neglected to cover the first time around, I have produced another list of the top stories from 2012.

And much like last time, I have listed them according to alphabetical order, since I couldn’t possibly assign them numbers based on importance.

Abortion Study:
anti-abortion-pushAbortion has always been a contentious issue, with one side arguing for the rights of the unborn while the other argues in favor of women’s right to control her own body and reproduction. And as it happens, 2012 saw the publication of the first longitudinal study of what happens to women who are denied this right.

The UC San Francisco research team, Advancing New Standards in Reproductive Health (ANSIRH), studied nearly 1,000 women from diverse backgrounds across the U.S. over several years. All of these subjects were women had sought out abortions but been denied access for one reason or another. What they discovered was that these women were more likely to slip below the poverty line, be unemployed, remain in abusive relationships, and suffer from hyper stress. What this ongoing study demonstrates is that abortion is an economic issue for women, with dire consequences for those denied them.

Autism Reversed:
mice2012 was an especially significant year in medical advances thanks to a team at McGill University in Montreal announced that they’ve successfully reversed the symptoms of autism in mice. Using mice with autism-like symptoms caused by a genetic mutation, the researchers figured out how to administer a protein that reversed the symptoms.

Naturally, this development is a step in the long process of understanding a disorder which remains largely misunderstood. In addition, it may, in time, lead to the development of a gene therapy that will prevent autism from being triggered in children and even weed it out of parent’s genetic code, ensuring that their children will be immune.

Commercial Space Travel:
virgin_galacticIt has long been the dream of financiers, captains of industry and enthusiasts to create commercial space travel; a means for the average person to go into space, the moon, and even beyond. And all at a reasonable price! This dream is still the subject of speculation and fantasy, but 2012 was a year of firsts that made it seem that much closer.

For starters, Virgin Galactic, the brain-child of Richard Branson, began flight tests on SpaceShipTwo, the rocket ship that will take people into orbit. Then came Reaction Engines Limited with the proposed design for the hypersonic aerospace engine. And finally, there was the creation of Golden Spike, a company made up largely of former astronauts, who want to make commercial flight to the moon a go by 2020.

Electricity-Creating Virus:
M13_virusA breakthrough virus named M13 made news in 2012 for being the first ever virus that could turn physical activity into electricity. The key is what is known as the “piezoelectric effect,” which happens when certain materials like crystals (or viruses) emit a small amount of power when squeezed. Created by a  team of scientists at the Berkeley Lab, this genetically engineered M13 viruses was able to emit enough electricity to power a small LED screen, but poses no threat to humans. One day, all devices could be powered through the simple act of typing or walking, and buildings could be powered by absorbing people’s activity.

Encyclopedia of DNA (ENCODE):
encodeThe publication of the human genome back in the late 90’s was a major breakthrough for genetics and medical science. And in 2012, another breakthrough was achieved by researchers at USC with the publication of ENCODE – The Encyclopedia of DNA Elements Project. Unlike the previous project, these researchers were able not only to catalog the human genome’s various parts, but what those components actually do.

Among the initiative’s many findings was that so-called “junk DNA” – outlier DNA sequences that do not encode for protein sequences – are not junk at all, and are in fact responsible for such things as gene regulation, disease onset, and even human height. These findings will go a long way towards developing gene therapy, biotechnology that seeks to create artificial DNA and self-assembling structures, and even cloning.

Face Transplant:
FaceTransplant_6062012 was also the year that the first full-face transplant was ever conducted. The recipient in question was a man named Richard Norris, a man who lost significant portions of his face from a gunshot accident back in 1997. And after years of attempted reconstructive surgeries, doctors working out of the University of Maryland Medical Center performed a procedure that gave Mr. Norris a has face, teeth, tongue, and a completely new set of jaws.

Not only that, but within days of the surgery, Norris was able to move his facial muscle and jaw. Combined with the nature of the surgery itself, this is not short of unprecedented, and could mean a new age in which severe accident victims and veterans are able to recover fully from physical traumas and live perfectly normal, happy lives.

The Higgs Boson Discovered:
higgs_bosonI can’t believe I didn’t include this story last time, as it is possibly the biggest story of 2012, and perhaps one of the biggest stories since the millennium! 2012 will forever go down in history as the year that the Higgs Boson was discovered. After some 40 years of ongoing research, and fears that it would never be discovered, the last missing piece of The Standard Model of particle physics was found.

Not only does the existence of the Higgs Boson confirm that the Standard Model is valid, it also helps explain how other elementary particles get their mass. This will herald a new step in the advance of particle and the quantum physics, and could lead to the development of quantum computing, quantum generators, and a greater understand of the universe itself.

High-Tech Condom:
condom1Using a revolutionary nano-fabrication process known as electrospinning, researchers at the University of Washington have produced the world’s first female condom that not only prevents pregnancy and protects against HIV, but also evaporates after use. In addition, the manufacturing method used is a step in the direction of viable nanotechnology. Score one for safe sex, public health, and a waste free future permeated by tiny machines and smart materials! That’s a big score card…

Infinite Capacity Wireless:
vortex-radio-waves-348x1962012 was also the year that it was proven that it could be possible to boost the capacity of wireless communication infinitely. The discovery was first made by Bo Thide of the Swedish Institute of Space Physics and some Italian colleagues in Venice, and then confirmed by a team of American and Israeli researchers who used the technique to transmit data at a rate of 2.5 terabytes a second.

Conventional radio signals are transmitted on a flat plane, but Thide twisted the transmitting and receiving antennae into the shape of corkscrew. By adding another dimension to the mix, the technique added a lot of extra bandwidth. As a result, the problem of bandwidth crunches might be a thing of the past, not to mention problems of slow download/upload.

Google Neural Net:
googleneuralnetwork1Another first and definitely one of the biggest headlines of 2012, far as I was concerned. So why I forgot to include it last time is beyond me! For generations scientists have contemplating the idea of AI and wondered how and where the first leap might be made from basic computing towards true machine intelligence. And as it turns out, Google X Labs, the same place where Project Glass was conceived, seems to have accomplished just that.

The accomplishment came when the labs created a neural network based on sixteen core processors and a connectome with a billion connections. The network accomplished its first task by studying millions of images on Youtube and then demonstrating the ability to differentiate between the faces of cats and humans. This act of independent reasoning that went beyond mere image recognition, and is a major step towards the achievement of a fully-functional artificial intelligence.

Stem cell mammal:
stem_cellsFor the first time in history, researchers at Kyoto University created a mouse by using eggs derived from stem cells alone. The achievement once again shows the remarkable possibilities presented by regenerative technologies like stem cells, while raising pressing ethical questions about the potential for human births in which parents might not be required.

Water in the Solar System:
titan_lakes2012 was also the year that an unprecedented amount of discoveries were made in our solar system. In addition to all the interesting revelations made by the Curiosity Rover, a number of probes discovered water on Europa, Mercury, Titan, and other Saturnalian moons. Usually, this comes in the form of water saturated with hydrocarbons, as was evident on Titan, but the discoveries remain monumental.

In addition to Titan’s methane lakes and Nile-like river, ice and organic molecules were discovered near the poles of Mercury. Evidence of water was found on Mars, indicating the existence of rivers and oceans at one time, and the Cassini space probe confirmed that Enceladus has its own oceans. All of this bodes well for the future of space exploration and colonization, where domestic sources of water may be used for hydrogen cells, hydroponics and even drinking water.

World’s First Tractor Beam:
tractor_beamIn another interesting first, NASA scientists demonstrated in 2012 that another staple technology from Star Trek may be realizable. Yes, in addition to the warp drive, scientists scientists David Ruffner and David Grier demonstrated that a tractor beam may also be realizable in the not-too-distant future. And given the 100 Year Starship Project and other desires to commit to space exploration, such a device could come in mighty handy!

Using a prototype optical beam to pull a small sphere of silica (30 micrometers) suspended in water, Grier and Ruffner pioneered the use of a Bessel beam, a long-established concept, to pull an object of discernible size and mass around. Naturally, NASA hopes to create a more high-powered version of the technology for use on space craft down the road.

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Thank you once more for attending this symposium on technological breakthroughs during the year of 2012! It was a good year, wouldn’t you say? And barring the advent of killer robots sometime in the near future that unleash a nuclear holocaust on us and force us all to work as slaves, I think people will look back on these developments in a positive light.

Yes, assuming humanity can keep its wits about itself and ensure the ethical application of all we’ve accomplished, 2012 may be seen as a turning point, where incurable diseases became preventable, AI’s became realizable, and limitless communications, super-fast computations, paper-thin flexible devices, green technology, commercial spaceflight, and Solar planet colonization all became truly viable.

Source: extremetech.com, IO9.com