Biomedical Breakthroughs: “Biological” Pacemakers

biologicalpacemakersSince they were first developed some forty years ago, pacemakers have served an invaluable medical function. By stimulating the heart with electrical stimulation, they ensure that the recipients heart continues to beat at a steady rate. However, the implantation process calls for a major medical procedure, and the presence of the machine inside the body can lead to complications – i.e. infections.

Little wonder then why researchers are looking to create a better design to replace it with. However, up until now, proposed upgrades have focused on eliminating batteries (that require additional surgery to be replaced) with perpetual motion or piezeoelectric-powered devices. But this most recent proposal, which comes from the Cedars-Sinai Heart Institute in Los Angeles, looks to use the heart’s own cells to regulate it and keep it in working order.

piezoelectric-pacemakerIn an effort that was apparently the result of “dozens of years” worth of research, Dr. Eduardo Marbán and his research team used genes injected into the defective hearts of pigs to convert unspecialized heart cells into “biological pacemakers”. The pigs, all of which suffered from complete heart blocks, had the gene TBX18 injected into their hearts via what is described as a minimally invasive catheter procedure.

This caused some of the existing unspecialized cardiac cells to transform into sinuatrial node cells, which consist of tissue that initiates the electrical impulses that set the rhythm of the heart. The day after the procedure, the recipient pigs’ hearts were already beating faster than those of a control group and lasted for the duration of the 14-day study – indicating that the treatment could be a longer-term solution than previously thought.

biomedicineInitially, Marbán and his colleagues conceived of it more as a temporary fix for patients who were having problems with their man-made pacemakers. Now, they’re considering the possibility that it could be a long-term biological treatment. It could also be used on infants still in the womb, who can’t currently receive mechanical pacemakers. And while the research has so far been confined to pigs, human clinical studies could begin in as soon as three years.

In keeping with a trends in modern medicine, this gene therapy offers a potential third alternative to medical machiners and biomimetics. The one seeks to enhance the workings of our biological bodies through the addition of machinery while the other seeks to create machinery that mimics the bodies natural functions. But by simply programming the body to perform the role of machinery, we can cut out the middle man.

Sources: gizmag.com, cedars-sinai.edu

The 3-D Printing Revolution: 3-D Printed Spinal Cages

spinal-fusion-surgeryAdditive manufacturing has been a boon for many industries, not the least of which is medicine. In the past few years, medical researchers have been able to use the technology to generate custom-made implants for patients, such as skull and jaw implants, or custom-molded mouthpieces for people with sleep apnea. And now, a new type of 3-D printed spine cage has been created that will assist in spinal fusion surgery.

Used as a treatment for conditions such as disc degeneration and spinal instability, spinal fusion surgery is designed to help separate bones grow together into a solid composite structure. This is where the spine cage comes in, by acting as a replacement for deformed and damaged discs, serving to separate the vertebrae, align the spine and relieve spinal nerves from pressure.

3d_printed_spine_cage-2Much like its strength in other areas of medicine, the potential of 3-D printing in spinal fusion surgery lies in the ability to tailor it to the patient’s anatomy. Medicrea, a Paris-based orthopedic implant manufacturer, used custom software and imaging techniques to produce a Polyetherketoneketone (PEKK) spine cage, customized to perfectly fit a particular patient’s vertebral plates.

The surgery was performed in May, with the surgeon since hailing the procedure a success, due largely to the role of 3D printing.Dr. Vincent Fiere, the surgeon who performed the procedure at Hospital Jean Mermoz in Lyon, France, explained:

The intersomatic cage, specifically printed by Medicrea for my patient, positioned itself automatically in the natural space between the vertebrae and molded ideally with the spine by joining intimately with the end plates, despite their relative asymmetry and irregularity.

3d-printed-jawWhile this particular process is patent-pending, Medicrea is hopeful the breakthrough will pave the way for the development of similar implantable devices that can replace or reinforce damaged parts of the spine. Much like other implants that can be made on site and tailored to needs of individual patient’s, it will also speed up the delivery process for potentially life-saving surgeries.

C0mbined with the strides being made in the field of biomedicine (where it is used to create tailor-made organic tissues), 3-D printing is helping to usher in a future where medicine is more personalized, accessible and cost-effective.

Source: gizmag.com

Looking Forward: 10 Breakthroughs by 2025

BrightFutureWorld-changing scientific discoveries are emerging all the time; from drugs and vaccines that are making incurable diseases curable, to inventions that are making renewable energies cheaper and more efficient. But how will these develops truly shape the world of tomorrow? How will the combination of advancements being made in the fields of medical, digital and industrial technology come together to change things by 2025?

Well, according to the Thomson Reuters IP & Science unit – a leading intellectual property and collaboration platform – has made a list of the top 10 breakthroughs likely to change the world. To make these predictions, they  looked at two sorts of data – current scientific journal literature and patent applications. Counting citations and other measures of buzz, they identified 10 major fields of development, then made specific forecasts for each.

As Basil Moftah, president of the IP & Science business (which sells scientific database products) said:

A powerful outcome of studying scientific literature and patent data is that it gives you a window into the future–insight that isn’t always found in the public domain. We estimate that these will be in effect in another 11 years.

In short, they predict that people living in 2025 will have access to far more in the way of medical treatments and cures, food will be more plentiful (surprisingly enough), renewable energy sources and applications will be more available, the internet of things will become a reality, and quantum and medical science will be doing some very interesting thins.

1. Dementia Declines:
geneticsPrevailing opinion says dementia could be one of our most serious future health challenges, thanks in no small part to increased life expectancy. In fact, the World Health Organization expects the number of cases to triple by 2050. The Thomson Reuters report is far more optimistic though, claiming that a focus on the pathogenic chromosomes that cause neuro-degenerative disease will result in more timely diagnosis, and earlier, more effective treatment:

In 2025, the studies of genetic mutations causing dementia, coupled with improved detection and onset-prevention methods, will result in far fewer people suffering from this disease.

2. Solar Power Everywhere:
solarpowergeWith the conjunction of increased efficiencies, dropping prices and improved storage methods, solar power will be the world’s largest single source of energy by 2025. And while issues such as weather-dependence will not yet be fully resolved, the expansion in panel use and the incorporation of thin photovoltaic cells into just about every surface imaginable (from buildings to roadways to clothing) will means that solar will finally outstrip fossil fuels as coal as the predominant means of getting power.

As the authors of the report write:

Solar thermal and solar photovoltaic energy (from new dye-sensitized and thin-film materials) will heat buildings, water, and provide energy for devices in the home and office, as well as in retail buildings and manufacturing facilities.

3. Type 1 Diabetes Prevention:
diabetes_worldwideType 1 diabetes strikes at an early age and isn’t as prevalent as Type 2 diabetes, which comes on in middle age. But cases have been rising fast nonetheless, and explanations range from nutritional causes to contaminants and fungi. But the report gives hope that kids of the future won’t have to give themselves daily insulin shots, thanks to “genomic-editing-and-repairing” that it expects will fix the problem before it sets in. As it specifies:

The human genome engineering platform will pave the way for the modification of disease-causing genes in humans, leading to the prevention of type I diabetes, among other ailments.

4. No More Food Shortages:
GMO_seedsContrary to what many speculative reports and futurists anticipate, the report indicates that by the year 2025, there will be no more food shortages in the world. Thanks to a combination of lighting and genetically-modified crops, it will be possible to grow food quickly and easily in a plethora of different environments. As it says in the report:

In 2025, genetically modified crops will be grown rapidly and safely indoors, with round-the-clock light, using low energy LEDs that emit specific wavelengths to enhance growth by matching the crop to growth receptors added to the food’s DNA. Crops will also be bred to be disease resistant. And, they will be bred for high yield at specified wavelengths.

5. Simple Electric Flight:
Solar Impulse HB-SIA prototype airplane attends his first flight over PayerneThe explosion in the use of electric aircraft (be they solar-powered or hydrogen fueled) in the past few decades has led to predictions that by 2025, small electric aircraft will offset commercial flight using gas-powered, heavy jets. The report says advances in lithium-ion batteries and hydrogen storage will make electric transport a reality:

These aircraft will also utilize new materials that bring down the weight of the vehicle and have motors with superconducting technology. Micro-commercial aircraft will fly the skies for short-hop journeys.

6. The Internet of Things:
internet-of-things-2By 2025, the internet is likely to expand into every corner of life, with growing wifi networks connecting more people all across the world. At the same time, more and more in the way of devices and personal possessions are likely to become “smart” – meaning that they will can be accessed digitally and networked to other things. In short, the internet of things will become a reality. And the speed at which things move will vastly increase due to proposed solutions to the computing bottleneck.

Here’s how the report puts it:

Thanks to the prevalence of improved semiconductors, graphene-carbon nanotube capacitators, cell-free networks of service antenna, and 5G technology, wireless communications will dominate everything, everywhere.

7. No More Plastic Garbage:
110315-N-IC111-592Ever heard of the Great Pacific Garbage Patch (aka. the Pacific Trash Vortex), the mass of plastic debris in the Pacific Ocean that measures somewhere between 700,000 and 15,000,000 square kilometres (270,000 – 5,800,000 sq mi)? Well, according to the report, such things will become a thing of the past. By 2025, it claims, the “glucose economy” will lead to the predominance of packaging made from plant-derived cellulose (aka. bioplastics).

Because of this influx of biodegradable plastics, there will be no more permanent deposits of plastic garbage filling our oceans, landfills, and streets. As it says:

Toxic plastic-petroleum packaging that litters cities, fields, beaches, and oceans, and which isn’t biodegradable, will be nearing extinction in another decade. Thanks to advancements in the technology related to and use of these bio-nano materials, petroleum-based packaging products will be history.

8. More Precise Drugs:
drugsBy 2025, we’ll have sophisticated, personalized medicine, thanks to improved production methods, biomedical research, and the growth of up-to-the-minute health data being provided by wearable medical sensors and patches. The report also offers specific examples:

Drugs in development are becoming so targeted that they can bind to specific proteins and use antibodies to give precise mechanisms of action. Knowledge of specific gene mutations will be so much more advanced that scientists and physicians can treat those specific mutations. Examples of this include HER2 (breast cancer), BRAF V600 (melanoma), and ROS1 (lung cancer), among many others.

9. DNA Mapping Formalized:
DNA-1Recent explosions in genetic research – which include the Genome Project and ENCODE – are leading to a world where personal genetic information will become the norm. As a result, kids born in 2025 will be tested at the DNA level, and not just once or twice, but continually using nano-probes inserted in the body. The result will be a boon for anticipating genetic diseases, but could also raise various privacy-related issues. As it states:

In 2025, humans will have their DNA mapped at birth and checked annually to identify any changes that could point to the onset of autoimmune diseases.

10. Teleportation Tested:
quantum-entanglement1Last, but certainly not least, the report says research into teleportation will be underway. Between the confirmation of the Higgs Boson (and by extension, the Standard Model of particle physics), recent revelations about quantum entanglements and wormholes, and the discovery of the Amplituhedron, the field of teleportation is likely to produce some serious breakthroughs. No telling what these will be – be it the ability to teleport simple photons or something larger – but the fact that the research will be happening seems a foregone conclusion:

We are on the precipice of this field’s explosion; it is truly an emerging research front. Early indicators point to a rapid acceleration of research leading to the testing of quantum teleportation in 2025.

Summary:
Will all of these changes come to pass? Who knows? If history has taught us anything, it’s that predictions are often wrong and much in the way of exciting research doesn’t always make it to the market. And as always, various factors – such as politics, money, public resistance, private interests – have a way of complicating things. However, there is reason to believe that the aforementioned 10 things will become a viable reality. And Moftah believes we should be positive about the future:

[The predictions] are positive in nature because they are solutions researchers and scientists are working on to address challenges we face in the world today. There will always be obstacles and issues to overcome, but science and innovation give us hope for how we will address them.

I, for one, am happy and intrigued to see certain items making this list. The explosion in solar usage, bioplastics, and the elimination of food scarcity are all very encouraging. If there was one thing I was anticipating by 2025, it was increased drought and food shortages. But as the saying goes, “necessity is the mother of invention”. And as someone who has had two grandmothers who lived into their nineties and have both suffered from the scourges of dementia, it is good to know that this disease will be on the wane for future generations.

It is also encouraging to know that there will be better treatments for diseases like cancer, HIV, and diabetes. While the idea of a world in which all diseases are preventable and/or treatable worries some (on a count of how it might stoke overpopulation), no one who has ever lived with this disease, or known someone who has, would think twice if presented with a cure. And hardship, hunger, a lack of education, resources and health services are some of the main reasons for population explosions.

And, let’s face it, its good to live in an age where the future looks bright for a change. After a good century of total war, totalitarianism, atomic diplomacy, terrorism, and oh so much existential angst and dystopian fiction, it’s nice to think that the coming age will turn out alright after all.

Sources: fastcoexist.com, ip-science.thomsonreuters.com

A Cleaner Future: Contaminant-Detecting Water Sensor

https://i0.wp.com/f.fastcompany.net/multisite_files/fastcompany/imagecache/1280/poster/2014/05/3030503-poster-p-jack-and-beaker.jpgJack Andraka is at it again! For those who follow this blog (or subscribe to Forbes or watch TED Talks), this young man probably needs no introduction. But if not, then you might not known that Andraka is than the young man who – at 15 years of age – invented an inexpensive litmus test for detecting pancreatic cancer. This invention won him first prize at the 2012 Intel International Science and Engineering Fair (ISEF), and was followed up less than a year later with a handheld device that could detect cancer and even explosives.

And now, Andraka is back with yet another invention: a biosensor that can quickly and cheaply detect water contaminants. His microfluidic biosensor, developed with fellow student Chloe Diggs, recently took the $50,000 first prize among high school entrants in the Siemens We Can Change the World Challenge. The pair developed their credit card-sized biosensor after learning about water pollution in a high school environmental science class.

andraka_diggsAs Andraka explained:

We had to figure out how to produce microfluidic [structures] in a classroom setting. We had to come up with new procedures, and we custom-made our own equipment.

According to Andraka, the device can detect six environmental contaminants: mercury, lead, cadmium, copper, glyphosate, and atrazine. It costs a dollar to make and takes 20 minutes to run, making it 200,000 times cheaper and 25 times more efficient than comparable sensors. At this point, make scaled-down versions of expensive sensors that can save lives has become second nature to Andraka. And in each case, he is able to do it in a way that is extremely cost-effective.

andraka-inlineFor example, Andraka’s litmus test cancer-detector was proven to be 168 times faster than current tests, 90% accurate, and 400 times more sensitive. In addition, his paper test costs 26,000 times less than conventional methods – which include  CT scans, MRIs, Ultrasounds, or Cholangiopancreatography. These tests not only involve highly expensive equipment, they are usually administered only after serious symptoms have manifested themselves.

In much the same vein, Andraka’s handheld cancer/explosive detector was manufactured using simple, off-the-shelf and consumer products. Using a simple cell phone case, a laser pointer and an iPhone camera, he was able to craft a device that does the same job as a raman spectrometer, but at a fraction of the size and cost. Whereas a conventional spectrometer is the size of a room and costs around $100,000, his handheld device is the size of a cell phone and costs $15 worth of components.

andraka_seimensAs part of the project, Diggs and Andraka also developed an inexpensive water filter made out of plastic bottles. Next, they hope to do large-scale testing for their sensor in Maryland, where they live. They also want to develop a cell-phone-based sensor reader that lets users quickly evaluate water quality and post the test results online. Basically, its all part of what is fast becoming the digitization of health and medicine, where the sensors are portable and the information can be uploaded and shared.

This isn’t the only project that Andraka has been working on of late. Along with the two other Intel Science Fair finalists – who came together with him to form Team Gen Z – he’s working on a handheld medical scanner that will be entered in the Tricorder XPrize. This challenge offers $10 million to any laboratory or private inventors that can develop a device that can diagnose 15 diseases in 30 patients over a three-day period. while still being small enough to carry.

For more information on this project and Team Gen Z, check out their website here. And be sure to watch their promotional video for the XPrize competition:


Source:
fastcoexist.com

Frontiers of Neuroscience: Neurohacking and Neuromorphics

neural-network-consciousness-downloading-640x353It is one of the hallmarks of our rapidly accelerating times: looking at the state of technology, how it is increasingly being merged with our biology, and contemplating the ultimate leap of merging mind and machinery. The concept has been popular for many decades now, and with experimental procedures showing promise, neuroscience being used to inspire the next great leap in computing, and the advance of biomedicine and bionics, it seems like just a matter of time before people can “hack” their neurology too.

Take Kevin Tracey, a researcher working for the Feinstein Institute for Medical Research in Manhasset, N.Y., as an example. Back in 1998, he began conducting experiments to show that an interface existed between the immune and nervous system. Building on ten years worth of research, he was able to show how inflammation – which is associated with rheumatoid arthritis and Crohn’s disease – can be fought by administering electrical stimulu, in the right doses, to the vagus nerve cluster.

Brain-ScanIn so doing, he demonstrated that the nervous system was like a computer terminal through which you could deliver commands to stop a problem, like acute inflammation, before it starts, or repair a body after it gets sick.  His work also seemed to indicate that electricity delivered to the vagus nerve in just the right intensity and at precise intervals could reproduce a drug’s therapeutic reaction, but with greater effectiveness, minimal health risks, and at a fraction of the cost of “biologic” pharmaceuticals.

Paul Frenette, a stem-cell researcher at the Albert Einstein College of Medicine in the Bronx, is another example. After discovering the link between the nervous system and prostate tumors, he and his colleagues created SetPoint –  a startup dedicated to finding ways to manipulate neural input to delay the growth of tumors. These and other efforts are part of the growing field of bioelectronics, where researchers are creating implants that can communicate directly with the nervous system in order to try to fight everything from cancer to the common cold.

human-hippocampus-640x353Impressive as this may seem, bioelectronics are just part of the growing discussion about neurohacking. In addition to the leaps and bounds being made in the field of brain-to-computer interfacing (and brain-to-brain interfacing), that would allow people to control machinery and share thoughts across vast distances, there is also a field of neurosurgery that is seeking to use the miracle material of graphene to solve some of the most challenging issues in their field.

Given graphene’s rather amazing properties, this should not come as much of a surprise. In addition to being incredibly thin, lightweight, and light-sensitive (it’s able to absorb light in both the UV and IR range) graphene also a very high surface area (2630 square meters per gram) which leads to remarkable conductivity. It also has the ability to bind or bioconjugate with various modifier molecules, and hence transform its behavior. 

brainscan_MRIAlready, it is being considered as a possible alternative to copper wires to break the energy efficiency barrier in computing, and even useful in quantum computing. But in the field of neurosurgery, where researchers are looking to develop materials that can bridge and even stimulate nerves. And in a story featured in latest issue of Neurosurgery, the authors suggest thatgraphene may be ideal as an electroactive scaffold when configured as a three-dimensional porous structure.

That might be a preferable solution when compared with other currently vogue ideas like using liquid metal alloys as bridges. Thanks to Samsung’s recent research into using graphene in their portable devices, it has also been shown to make an ideal E-field stimulator. And recent experiments on mice in Korea showed that a flexible, transparent, graphene skin could be used as a electrical field stimulator to treat cerebral hypoperfusion by stimulating blood flow through the brain.

Neuromorphic-chip-640x353And what look at the frontiers of neuroscience would be complete without mentioning neuromorphic engineering? Whereas neurohacking and neurosurgery are looking for ways to merge technology with the human brain to combat disease and improve its health, NE is looking to the human brain to create computational technology with improved functionality. The result thus far has been a wide range of neuromorphic chips and components, such as memristors and neuristors.

However, as a whole, the field has yet to define for itself a clear path forward. That may be about to change thanks to Jennifer Hasler and a team of researchers at Georgia Tech, who recently published a roadmap to the future of neuromorphic engineering with the end goal of creating the human-brain equivalent of processing. This consisted of Hasler sorting through the many different approaches for the ultimate embodiment of neurons in silico and come up with the technology that she thinks is the way forward.

neuromorphic-chip-fpaaHer answer is not digital simulation, but rather the lesser known technology of FPAAs (Field-Programmable Analog Arrays). FPAAs are similar to digital FPGAs (Field-Programmable Gate Arrays), but also include reconfigurable analog elements. They have been around on the sidelines for a few years, but they have been used primarily as so-called “analog glue logic” in system integration. In short, they would handle a variety of analog functions that don’t fit on a traditional integrated circuit.

Hasler outlines an approach where desktop neuromorphic systems will use System on a Chip (SoC) approaches to emulate billions of low-power neuron-like elements that compute using learning synapses. Each synapse has an adjustable strength associated with it and is modeled using just a single transistor. Her own design for an FPAA board houses hundreds of thousands of programmable parameters which enable systems-level computing on a scale that dwarfs other FPAA designs.

neuromorphic_revolutionAt the moment, she predicts that human brain-equivalent systems will require a reduction in power usage to the point where they are consuming just one-eights of what digital supercomputers that are currently used to simulate neuromorphic systems require. Her own design can account for a four-fold reduction in power usage, but the rest is going to have to come from somewhere else – possibly through the use of better materials (i.e. graphene or one of its derivatives).

Hasler also forecasts that using soon to be available 10nm processes, a desktop system with human-like processing power that consumes just 50 watts of electricity may eventually be a reality. These will likely take the form of chips with millions of neuron-like skeletons connected by billion of synapses firing to push each other over the edge, and who’s to say what they will be capable of accomplishing or what other breakthroughs they will make possible?

posthuman-evolutionIn the end, neuromorphic chips and technology are merely one half of the equation. In the grand scheme of things, the aim of all of this research is not only produce technology that can ensure better biology, but technology inspired by biology to create better machinery. The end result of this, according to some, is a world in which biology and technology increasingly resemble each other, to the point that they is barely a distinction to be made and they can be merged.

Charles Darwin would roll over in his grave!

Sources: nytimes.com, extremetech.com, (2), journal.frontiersin.orgpubs.acs.org

The Future is Here: “Terminator-style” Liquid Metal Treatment

t1000_1For ideal physical rehab, it might be necessary to go a little “cyborg”. That’s the reasoning a Chinese biomedical firm used to develop a new method of repairing damaged nerve endings. Borrowing a page from Terminator 2, their new treatment calls for the use of liquid metal to transmit nerve signals across the gap created in severed nerves. The work, they say, raises the prospect of new treatment methods for nerve damage and injuries.

Granted, it’s not quite on par with the liquid-metal-skinned cyborgs from the future, but it is a futuristic way of improving on current methods of nerve rehab that could prevent long-term disabilities. When peripheral nerves are severed, the loss of function leads to atrophy of the effected muscles, a dramatic change in quality of life and, in many cases, a shorter life expectancy. Despite decades of research, nobody has come up with an effective way to reconnect them yet.

nerveVarious techniques exist to sew the ends back together or to graft nerves into the gap that is created between severed ends. And the success of these techniques depends on the ability of the nerve ends to grow back and knit together. But given that nerves grow at the rate of one mm per day, it can take a significant amount of time (sometimes years) to reconnect. And during this time, the muscles can degrade beyond repair and lead to long-term disability.

As a result, neurosurgeons have long hoped for a way to keep muscles active while the nerves regrow. One possibility is to electrically connect the severed ends so that the signals from the brain can still get through; but up until now, an effective means of making this happen has remained elusive. For some time, biomedical engineers have been eyeing the liquid metal alloy gallium-indium-selenium for some time as a possible solution – a material that is liquid at body temperature and thought to be entirely benign.

Liquid metal nervesBut now, a biomedical research team led by Jing Liu of Tsinghua University in Beijing claims they’ve reconnected severed nerves using liquid metal for the first time. They claim that the metal’s electrical properties could help preserve the function of nerves while they regenerate. Using sciatic nerves connected to a calf muscle, which were taken from bullfrogs, they’ve managed to carry out a series of experiments that prove that the technique is viable.

Using these bullfrog nerves, they applied a pulse to one end and measured the signal that reached the calf muscle, which contracted with each pulse. They then cut the sciatic nerve and placed each of the severed ends in a capillary filled either with liquid metal or with Ringer’s solution – a solution of several salts designed to mimic the properties of body fluids. They then re-applied the pulses and measured how they propagated across the gap.

liquid metal nerves_1The results are interesting, and Jing’s team claim that the pulses that passed through the Ringer’s solution tended to degrade severely. By contrast, the pulses passed easily through the liquid metal. As they put it in their research report:

The measured electroneurographic signal from the transected bullfrog’s sciatic nerve reconnected by the liquid metal after the electrical stimulation was close to that from the intact sciatic nerve.

What’s more, since liquid metal clearly shows up in x-rays, it can be easily removed from the body when it is no longer needed using a microsyringe. All of this has allowed Jing and colleagues to speculate about the possibility of future treatments. Their goal is to make special conduits for reconnecting severed nerves that contain liquid metal to preserve electrical conduction and therefore muscle function, but also containing growth factor to promote nerve regeneration.

future_medicineNaturally, there are still many challenges and unresolved questions which must be resolved before this can become a viable treatment option. For example, how much of the muscle function can be preserved? Can the liquid metal somehow interfere with or prevent regeneration? And how safe is liquid metal inside the body – especially if it leaks? These are questions that Jing and others will hope to answer in the near future, starting with animal models and possibly later with humans..

Sources: technologyreview.com, arxiv.org, cnet.com, spectrum.ieee.org

Happy DNA Day!

dna_cancerThough I am a week late in expressing this sentiment, I feel I must acknowledge this rather interesting of events. As it stands, this past April 22nd was the sixty-first anniversary of the molecular structure of DNA being revealed to the world. What began as a publication in the magazine Nature has now become emblematic of the programming language of life, and our understanding of DNA has grown by leaps and bounds over the past six decades.

To commemorate such an important landmark in the history of humanity, a look back at some of the more recent developments in the field of genetic research would seem to be in order. For example, it was on April 22nd of this year that a rather interesting study was published in the Proceedings of the National Academy of Sciences. The lead on this study was none other than Svante Pääbo – the world’s foremost expert in Neanderthal genetics.

humanEvolutionBased on the genomes of three neanderthals that were found in disparate locations in Eurasia, Pääbo and his colleagues have concluded that the genetic diversity in Neanderthals is significantly less when compared to present-day Homo sapiens. It also appears as if the Neanderthal populations were relatively isolated and tiny, so gene flow was extremely limited for these groups. In short, our homonid cousins didn’t get around and interbreed quite as much as we’ve done, which may shed some light on their disappearance.

On the very same day, an article was published in the Proceedings of the Royal Society B that proposed that skin cancer from the sun’s damaging UV rays was actually a driving force in the national selection for dark skin in early humans. In the article, Mel Greaves delivers a compelling argument that the deadliness of skin cancer in young albino children in Africa and Central America demonstrates just how vital it was for early humans to develop dark skin.

GenoChipAnd on April 25th, National Geographic and Family Tree DNA teamed up to announce the release of a brand new version of the human Y-DNA tree. This new tree of Y chromosome mutations has over 1,200 branches — almost double the number of branches that the Genographic Project was displaying before. With this much refinement, it’s now even easier to track the historical migrations of your distant ancestors.

To celebrate this monumental roll-out, Family Tree DNA offered a 20% discount on the 37-marker Y-DNA test and all individual Y-DNA SNP (single-nucleotide polymorphism) tests, an offer which sadly expired on April 27th. However, interested parties can still have this cutting-edge anthropological genetic test performed for $200. And it’s something to keep in mind for next year certainly. What better way to celebrate DNA day than to have a full genetic profile of yourself made?

encodeAnd let’s not forget, 2012 was also the year that the Encyclopedia of DNA Elements (ENCODE) Consortium – an international collaboration of research groups funded by the National Human Genome Research Institute (NHGRI) – released the world’s most complete report on the human genome to date. Unlike the Human Genome Project, which released the first catalog of human DNA back in 2003, ENCODE was not only able to catalog the human genome’s various parts, but also what those components actually do.

Among the initiative’s many findings was that so-called “junk DNA” – outlier DNA sequences that do not encode for protein sequences – are not junk at all, and are in fact responsible for such things as gene regulation, disease onset, and even human height. As I’ve said before, these findings will go a long way towards developing gene therapy, biotechnology that seeks to create artificial DNA and self-assembling structures, and even cloning.

Tree-600x405Yes, it’s an exciting time for the field of DNA research, and not just because of the many doors its likely to open. Beyond medical and bioresearch, it helps us to understand of ourselves as a species, our collective origins, and may perhaps help us to see just how interconnected we all truly are. For centuries now, a great many evils and prejudices have been committed in the name of “racial superiority” or racial differences.

Armed with this new knowledge, we might just come to realize that this great organism known as humanity is all fruit of the same tree.

Sources: extremetech.com, genome.ucsc.edu, newswatch.nationalgeographic.com

The Future of Medicine: Replacement Ears and “Mini Hearts”

biomedicineBiomedicine is doing some amazing things these days, so much so that I can hardly keep up with the rate of developments. Just last month, two amazing ones were made, offering new solutions for replacing human tissue and treating chronic conditions. The first has to do with a new method of growing human using a patients own DNA, while the second involves using a patient’s own heart tissue to create “mini hearts” to aid in circulation.

The first comes from London’s Great Ormond Street Hospital, where researchers are working on a process that will grow human ears using genetic material taken from a patient’s own fat tissue. Building upon recent strides made in the field of bioprinting, this process will revolution reconstructive surgery as we know it. It also seeks to bring change to an area of medicine which, despite being essential for accident victims, has been sadly lacking in development.

replacement_earCurrently, the procedure to repair damaged or non-existent cartilage in the ear involves an operation that is usually carried out when the patient is a child. For the sake of this procedure, cartilage is extracted from the patient’s ribs and painstakingly crafted into the form of an ear before being grafted back onto the individual. Whilst this method of reconstruction achieves good results, it also comes with its share of unpleasant side effects.

Basically, the patient is left with a permanent defect around the area from where the cells were harvested, as the cartilage between the ribs does not regenerate. In this new technique, the cartilage cells are engineered from mesenchymal stem cells, extracted from the child’s abdominal adipose (fat) tissue. The benefit of this new system is that unlike the cartilage in the ribs, the adipose tissue regenerates, therefore leaving no long-term defect to the host.

stem_cells1There is also the potential to begin reconstructive treatment with stem cells derived from adipose tissue earlier than previously possible, as it takes time for the ribs to grow enough cartilage to undergo the procedure. As Dr. Patrizia Ferretti, a researcher working on the project, said in a recent interview:

One of the main benefits in using the patient’s own stem cells is that there is no need for immune suppression which would not be desirable for a sick child, and would reduce the number of severe procedures a child needs to undergo.

To create the form of the ear, a porous polymer nano-scaffold is placed in with the stem cells. The cells are then chemically induced to become chondrocytes (aka. cartilage cells) while growing into the holes in the scaffold to create the shape of the ear. According to Dr. Ferretti, cellularized scaffolds – themselves a recent medical breakthrough – are much better at integrating than fully-synthetic implants, which are more prone to extrusion and infection.

cartilage2Dr. Ferretti continued that:

While we are developing this approach with children with ear defects in mind, it could ultimately be utilized in other types of reconstructive surgery both in children and adults.

Basically, this new, and potentially more advantageous technique would replace the current set of procedures in the treatment of defects in cartilage in children such as microtia, a condition which prevents the ear from forming correctly. At the same time, the reconstructive technology also has the potential to be invaluable in improving the quality of life of those who have been involved in a disfiguring accident or even those injured in the line of service.

mini_hearts`Next up, there is the “mini heart” created by Dr. Narine Sarvazyan of George Washington University in Washington D.C.. Designed to be wrapped around individual veins, these cuffs of rhythmically-contracting heart tissue are a proposed solution to the problem of chronic venous insufficiency – a condition where leg veins suffer from faulty valves, which prevents oxygen-poor blood from being pumped back to the heart.

Much like process for creating replacement ears, the mini hearts are grown  by coaxing a patient’s own adult stem cells into becoming cardiac cells. When one of those cuffs is placed around a vein, its contractions aid in the unidirectional flow of blood, plus it helps keep the vein from becoming distended. Additionally, because it’s grown from the patient’s own cells, there’s little chance of rejection. So far, the cuffs have been grown in the lab, where they’ve also been tested. But soon, Sarvazyan hopes to conduct animal trials.

mini_hearts2As Sarvazyan explained, the applications here far beyond treating venous insufficiency. In addition, there are the long-range possibilities for organ replacement:

We are suggesting, for the first time, to use stem cells to create, rather than just repair damaged organs. We can make a new heart outside of one’s own heart, and by placing it in the lower extremities, significantly improve venous blood flow.

One of the greatest advantages of the coming age of biomedicine is the ability to replace human limbs, organs and tissue using organic substitutions. And the ability to grow these from the patient’s own tissue is a major plus, in that it cuts down on the development process and ensures a minimal risk of rejection. On top of all that, the ability to create replacement organs would also significantly cut down on the costs of replacement tissue, as well as the long waiting periods associated with donor lists.

Imagine that, if you will. A future where a patient suffering from liver, kidney, circulatory, or heart problems is able to simply visit their local hospital or clinic, donate a meager supply of tissue, and receive a healthy, fully-compatible replacement after an intervening period (days or maybe even hours). The words “healthy living” will achieve new meaning!

 

Sources: gizmag.com, (2), nanomedjournal.com

News in Bionics: Restoring Sensation and Mobility!

TED_adrianne1It seems like I’ve writing endlessly about bionic prosthetics lately, thanks to the many breakthroughs that have been happening almost back to back. But I would be remiss if I didn’t share these latest two. In addition to showcasing some of the latest technological innovations, these stories are inspiring and show the immense potential bionic prosthetics have to change lives and help people recover from terrible tragedies.

For instance, on the TED stage this week in Vancouver, which included presentations from astronaut Chris Hadfield, NSA whistle blower Edward Snowden, and anti-corruption activist Charmiah Gooch, there was one presentation that really stole the stage. It Adrianne Haslet-Davis, a former dance instructor and a survivor of the Boston Marathon bombing, dancing again for the first time. And it was all thanks to a bionic limb developed by noted bionics researcher Hugh Herr. 

TED_hugh_herrAs the director of the Biomechatronics Group at the MIT Media Lab, Herr is known for his work on high-tech bionic limbs and for demonstrating new prosthetic technologies on himself. At 17, he lost both his legs in a climbing accident. After discussing the science of bionic limbs, Herr brought out Adrianne, who for the first time since her leg amputation, performed a short ballroom dancing routine.

This was made possible thanks to the help of a special kind of bionic limb that designed by Herr and his colleagues at MIT specifically for dancing. The design process took over 200 days, where the researchers studied dance, brought in dancers with biological limbs, studied how they moved, and examined the forces they applied on the dance floor. What resulted was a “dance limb” with 12 sensors, a synthetic motor system that can move the joint, and microprocessors that run the limb’s controllers.

TED_adrianne2The system is programmed so that the motor moves the limb in a way that’s appropriate for dance. As Herr explained in a briefing after his talk:

It was so new. We had never looked at something like dance. I understand her dream and emotionally related to her dream to return to dance. It’s similar to what I went through.” Herr says he’s now able to climb at a more advanced level than when he had biological legs.

Haslet-Davis’s new limb is only intended for dancing; she switches to a different bionic limb for regular walking. And while this might seem like a limitation, it in fact represents a major step in the direction of bionics that can emulate a much wider range of human motion. Eventually, Herr envisions a day when bionic limbs can switch modes for different activities, allowing a person to perform a range of different tasks – walking, running, dancing, athletic activity – without having to change prosthetics.

TED_adrianneIn the past, Herr’s work has been criticized by advocates who argue that bionic limbs are a waste of time when many people don’t even have access to basic wheelchairs. He argues, however, that bionic limbs–which can cost as much as a nice car–ultimately reduce health care costs. For starters, they allow people to return to their jobs quickly, Herr said, thus avoiding workers’ compensation costs.

They can also prevent injuries resulting from prosthetics that don’t emulate normal function as effectively as high-tech limbs. And given the fact that the technology is becoming more widespread and additive manufacturing is leading to lower production costs, there may yet come a day when a bionic prosthetic is not beyond the means of the average person. Needless to say, both Adrianne and the crowd were moved to tears by the moving and inspiring display!

bionic_hand_MIT1Next, there’s the inspiring story of Igor Spectic, a man who lost his right arm three years ago in a workplace accident. Like most people forced to live with the loss of a limb, he quickly came to understand the limitations of prosthetics. While they do restore some degree of ability, the fact that they cannot convey sensation means that the wearers are often unaware when they have dropped or crushed something.

Now, Spectic is one of several people taking part in early trials at Cleveland Veterans Affairs Medical Center, where researchers from Case Western Reserve University are working on prosthetics that offer sensation as well as ability. In a basement lab, the trials consist of connecting his limb to a prosthetic hand, one that is rigged with force sensors that are plugged into 20 wires protruding from his upper right arm.

bionic_hand_MITThese wires lead to three surgically implanted interfaces, seven millimeters long, with as many as eight electrodes apiece encased in a polymer, that surround three major nerves in Spetic’s forearm. Meanwhile, a nondescript white box of custom electronics does the job of translating information from the sensors on Spetic’s prosthesis into a series of electrical pulses that the interfaces can translate into sensations.

According to the trial’s leader, Dustin Tyler – a professor of biomedical engineering at Case Western Reserve University and an expert in neural interfaces – this technology is “20 years in the making”. As of this past February, the implants had been in place and performing well in tests for more than a year and a half. Tyler’s group, drawing on years of neuroscience research on the signaling mechanisms that underlie sensation, has developed a library of patterns of electrical pulses to send to the arm nerves, varied in strength and timing.

bionic_hand_MIT2Spetic says that these different stimulus patterns produce distinct and realistic feelings in 20 spots on his prosthetic hand and fingers. The sensations include pressing on a ball bearing, pressing on the tip of a pen, brushing against a cotton ball, and touching sandpaper. During the first day of tests, Spetic noticed a surprising side effect: his phantom fist felt open, and after several months the phantom pain was “95 percent gone”.

To test the hand’s ability to provide sensory feedback, and hence aid the user in performing complex tasks, Spetic and other trial candidates were tasked with picking up small blocks that were attached to a table with magnets, as well as handling and removing the stems from a bowl of cherries. With sensation restored, he was able to pick up cherries and remove stems 93 percent of the time without crushing them, even blindfolded.

bionic_hand_MIT_demoWhile impressive, Tyler estimates that completing the pilot study, refining stimulation methods, and launching full clinical trials is likely to take 10 years. He is also finishing development of an implantable electronic device to deliver stimuli so that the technology can make it beyond the lab and into a household setting. Last, he is working with manufacturers of prostheses to integrate force sensors and force processing technology directly into future versions of the devices.

As for Spetic, he has drawn quite a bit of inspiration from the trials and claims that they have left him thinking wistfully about what the future might bring. As he put it, he feels:

…blessed to know these people and be a part of this. It would be nice to know I can pick up an object without having to look at it, or I can hold my wife’s hand and walk down the street, knowing I have a hold of her. Maybe all of this will help the next person.

bionic-handThis represents merely one of several successful attempts to merge the technology of nerve stimulation in with nerve control, leading to bionic limbs that not only obey user’s commands, but provide sensory feedback at the same time. Given a few more decades of testing and development, we will most certainly be looking at an age where bionic limbs that are virtually indistiguishable from the real thing exist and are readily available.

And in the meantime, enjoy this news story of Adrianne Haslet-Davis performing her ballroom dance routine at TED. I’m sure you’ll find it inspiring!


Sources: fastcoexist.com, technologyreview.com, blog.ted.com

The Future of Medicine: Tiny Bladder and Flashlight Sensors

heart_patchesThere’s seems to be no shortage of medical breakthroughs these days! Whether it’s bionic limbs, 3-D printed prosthetic devices, bioprinting, new vaccines and medicines, nanoparticles, or embedded microsensors, researchers and medical scientists are bringing innovation and technological advancement together to create new possibilities. And in recent months, two breakthrough in particular have bbecome the focus of attention, offering the possibility of smarter surgery and health monitoring.

First up, there’s the tiny bladder sensor that is being developed by the Norwegian research group SINTEF. When it comes to patients suffering from paralysis, the fact that they cannot feel when their bladders are full, para and quadriplegics often suffer from pressure build-up that can cause damage to the bladder and kidneys. This sensor would offer a less invasive means of monitoring their condition, to see if surgery is required or if medication will suffice.

pressuresensorPresently, doctors insert a catheter into the patient’s urethra and fill their bladder with saline solution, a process which is not only uncomfortable but is claimed to provide an inaccurate picture of what’s going on. By contrast, this sensor can be injected directly into the patients directly through the skin, and could conceivably stay in place for months or even years, providing readings without any discomfort, and without requiring the bladder to be filled mechanically.

Patients would also able to move around normally, plus the risk of infection would reportedly be reduced. Currently readings are transmitted from the prototypes via a thin wire that extents from the senor out through the skin, although it is hoped that subsequent versions could transmit wirelessly – most likely to the patient’s smartphone. And given that SINTEF’s resume includes making sensors for the CERN particle collider, you can be confident these sensors will work!

senor_cern_600Next month, a clinical trial involving three spinal injury patients is scheduled to begin at Norway’s Sunnaas Hospital. Down the road, the group plans to conduct trials involving 20 to 30 test subjects. Although they’re currently about to be tested in the bladder, the sensors could conceivably be used to measure pressure almost anywhere in the body. Conceivably, sensors that monitor blood pressure and warn of aneurisms or stroke could be developed.

Equally impressive is the tiny, doughnut-shaped sensor being developed by Prof. F. Levent Degertekin and his research group at the George W. Woodruff School of Mechanical Engineering at Georgia Tech. Designed to assist doctors as they perform surgery on the heart or blood vessels, this device could provide some much needed (ahem) illumination. Currently, doctors and scientists rely on images provided by cross-sectional ultrasounds, which are limited in terms of the information they provide.

tiny_flashlightAs Degertekin explains:

If you’re a doctor, you want to see what is going on inside the arteries and inside the heart, but most of the devices being used for this today provide only cross-sectional images. If you have an artery that is totally blocked, for example, you need a system that tells you what’s in front of you. You need to see the front, back, and sidewalls altogether.

That’s where their new chip comes into play. Described as a “flashlight” for looking inside the human body, it’s basically a tiny doughnut-shaped sensor measuring 1.5 millimeters (less than a tenth of an inch) across, with the hole set up to take a wire that would guide it through cardiac catheterization procedures. In that tiny space, the researchers were able to cram 56 ultrasound transmitting elements and 48 receiving elements.

georgia-tech-flashlight-vessels-arteries-designboom03So that the mini monitor doesn’t boil patients’ blood by generating too much heat, it’s designed to shut its sensors down when they’re not in use. In a statement released from the university, Degertekin explained how the sensor will help doctors to better perform life-saving operations:

Our device will allow doctors to see the whole volume that is in front of them within a blood vessel. This will give cardiologists the equivalent of a flashlight so they can see blockages ahead of them in occluded arteries. It has the potential for reducing the amount of surgery that must be done to clear these vessels.

Next up are the usual animal studies and clinical trials, which Degertekin hopes will be conducted by licensing the technology to a medical diagnostic firm. The researchers are also going to see if they can make their device even smaller- small enough to fit on a 400-micron-diameter guide wire, which is roughly four times the diameter of a human hair. At that size, this sensor will be able to provide detailed, on-the-spot information about any part of the body, and go wherever doctors can guide it.

Such is the nature of the new age of medicine: smaller, smarter, and less invasive, providing better information to both save lives and improve quality of life. Now if we can just find a cure for the common cold, we’d be in business!

Sources: gizmag.com, news.cnet.com