The Future of Money

future_money4The good people over at Envisioning Technology – the independent research organization based on Brazil – have produced yet another intriguing infographic. As some of you may recall, whenever ET has released a new inforgraphic, I’ve been right there to post about it. So far, they have produced graphics addressing the future of Technology, Education, Health, and Finance.

There latest graphic is similarly significant and addresses the future of something that concerns and effects us all: money. Entitled “The Past, Present and Future of Money”, this graph looks at the trends affecting the buying, selling and investment patterns of people over time, contrasting three trends that are interwoven and have moved between centralized, decentralized, and distributed monetary systems.

future_money1In this scenario, centralized tendencies refer to networks where the nodes are connected through dense centers (aka. urban environments), which rely on hierarchically structures institutions (i.e. banks) and require legal tender (physical money). This sort of system relies on an ordered distribution of power, one that generally favor the connected few, and which emerged with the advent of modern industrial civilization.

Decentralized tendencies are those which are based on networks where nodes connect in clusters, that have irregular distributions of power, and favor the selected individual. As the graph shows, these types of networks predate centralized networks, taking the form of bartering and commodities in earliest times, but which have emerged yet again in the modern era and are predicted to continue to grow.

PrintExamples of current and future trends here include crowdsourcing, crowdfunding, banking APIs (Application Programming Interfaces), microfinance, and collaborative consumptions – where access is developed so that consumers can lend, swap, barter, share, and gift products. Whereas this model predates centralized tendencies, it is once again emerging with decentralizing potential of digital technology and open-source databases.

In the third and final method, one which is emerging, is the distributed network of money. These are networks where nodes connect independently, where power is distributed horizontally, and which favor the entire network. This trend began as a result of global real-time communications (i.e. the internet, satellite communications, etc.), and which are expected to expand.

future_money2Combining the concepts of attention economies, digital currencies, peer-to-peer communications, and digital wallets, the essence of this final stage is a network economy that is controlled by individuals, not financial institutions or corporations. In addition, currencies are based shared belief in their value, transactions occur between individuals, and physical currencies are replaced by digital ones.

Other trends that are incorporated and cross-referenced into this infographic include global population versus the number of people per capita who have online access. As it stands, less than half the world’s 7 billion people currently have access to the internet, and are hence able to take part in the decentralizing and distributed trends affecting money. However, the infographic predicts that by 2063, nearly 90% of the world’s 10 billion people will be online.

future_money_bitcoinLike many predictions that I’ve come to know and respect, this latest infographic from ET gives us a glimpse of a future where a Distributed model of politics, economics and technological development – otherwise known as Democratic Anarchy – will be the norm. It’s an exciting possibility, and places history in a new and interesting light. In short, it makes one reconsider the possibility that true socialism might exist.

While this was crudely predicted by Karl Marx, the basic concept is quite intriguing when considered in the context of current trends. What’s more, subsequent thinkers – Max Weber, Proudhon, Gramsci and George Orwell – refined and expressed the principle more eloquently. Nowhere was this more apparent than in the Goldstein Manifesto in 1984, where Orwell addressed how the process of industrial civilization was making class distinction virtually unnecessary.


The Future of Medicine: Anti-Bleeding Clamps

itclamp2For centuries, medics have been forced to deal with cuts and lacerations by simply binding up wounds with bandages and wraps. Time has led to refinements in this process, replacing cloth with sterile bandages. But the basic process has remained the same. But now, severe cuts and bleeding have a new enemy, thanks to a new breed of clamping devices.

One such device is the iTClamp Hemmorage Control System, which won an award for top innovation in 2012 and was recently approved by the FDA. Basically, this clamp is placed over an open wound and then controls bleeding by sealing the edges shut to temporarily create a pool of blood under pressure and thereby form a clot that helps reduce more blood loss until surgery.

itclampThis past summer, the clamp got its first field test on a man who fell prey to a chainsaw wound on his upper arm just outside of Olive Branch, Mississippi. The hospital air crew who arrived on scene quickly determined that a tourniquet would not work, but were able to stop the bleeding and stabilize the patient within minutes, at which point they transported him to the Regional Medical Center of Memphis.

The clamp was invented by Dennis Filips, who served three tours in Afghanistan as a trauma surgeon for the Canadian Navy. With the saving of a life in the US, he has watched what began as an idea turn into a dream come true:

To have our first human use in the US turn out so well is thrilling, and we look forward to getting the iTClamp into the hands of first responders across the country and around the world.

ITClamp3The clamp is currently being sold for around $100 via various distributors across the US, and it’s available in Canada and Europe as well. At that price it could very well end up being adopted not only by first responders, but climbers and other adventurers looking to beef up their first-aid kits — and maybe the cautious chainsaw wielders among us as well.

And be sure to check out this video simulation of the iTClamp in action:


The Future of Medicine: Microneedle Patch

TB-resTubercle bacillus, aka. Tuberculosis or TB, is a very common, very infectious, and if untreated, very lethal disease. A well dated illness, its origins can be traced back to early Neolithic Revolution, and is often attributed to animal husbandry (specifically, the domestication of bovines). And in terms of the number of people carrying it, and the number of deaths associated with it, it is second only to HIV.

Because of this and the fact that the disease remains incurable – the only way to combat it is with early detection or experimental vaccines – it is obvious why medical researchers are looking for better ways to detect it. Currently, the standard test for tuberculosis involves inserting a hypodermic needle into a person’s arm at a very precise angle and depth, using a small trace of genetically modified TB to elicit an immuno-reaction.

TB_microneedlesAs anyone who has undergone this test knows (as a teacher, I have had to endure it twice!), it is not a very efficient or cost effective way of detecting the deadly virus. In addition to being uncomfortable, the telltale symptoms can days to manifest themselves. Hence why Researchers at the University of Washington hope to replace this test with a painless, near-automated alternative – a microneedle patch that they say is more precise and even biodegradable.

For their study, which was recently presented in the journal Advanced Healthcare Materials, the scientists used microneedles made from chitin – the material that makes up the shells sea creatures and insects and is biodegradable. Each needle is 750 micrometers long (1/40th of an inch) and is coated with the purified protein derivative used to test for tuberculosis.

TB_virusIn terms of its application, all people need do is put it on like a bandage, which ought to make testing on children much easier. For the sake of testing it, the team tested its microneedle patch on guinea pigs and found that the reaction that occurs via the hypodermic needle test also appeared using the patch. But the best aspect of it is the fact that the patch does not require any invasive or difficult procedures.

In a school news release, Marco Rolandi – assistant professor of materials science and engineering at the University of Washington and lead author of the study – had the following to say:

With a microneedle test there’s little room for user error, because the depth of delivery is determined by the microneedle length rather than the needle-insertion angle. This test is painless and easier to administer than the traditional skin test with a hypodermic needle.

medical technologyThe researchers report that they now plan to test the needle patch on humans and hope to make the patch available in the near future. However, the long-term benefits may go beyond stopping TB, as Rolandi and his team hope that similar patches will be developed for other diagnostic tests, such as those used to detect allergies. As anyone who has undergone an allergen test will tell you (again, twice!), its no picnic being pricked and scraped by needles!

As always, the future of medicine appears to be characterized by early detection, lower costs, and less invasive measures.

Sources:, washington,edu, who.nt

Jack Andraka and I Have a Chat!

photo(1)Folks, today I have a rare privilege which I want to share with you. Not that long ago, I reached out to a certain brilliant mind that’s been making waves in the scientific community of late, a young man who – despite his age – has been producing some life saving technologies and leading his own research team. This young man, despite his busy schedule, managed to get back to me quite quickly, and agreed to an interview.

I am of coarse referring to Jack Andraka, a man who’s medical science credentials are already pretty damn impressive. At the age of 16, he developed a litmus test that was capable of detecting pancreatic cancer, one that was 90% accurate, 168 times faster than current tests, and 1/26,000th the cost. For this accomplishment, he won first place at the 2012 Intel International Science and Engineering Fair (ISEF).

Winning at the 2012 ISEF
Winning at the 2012 ISEF

Afterward, he and the other finalists formed their own research group known as Generation Z, which immediately began working towards the creation of a handheld non-invasive device that could help detect cancer early on. In short, they began working on a tricorder-like device, something for which they hope to collect the Tricorder X PRIZE in the near future.

While this project is ongoing, Andraka presented his own concept for a miniature cancer-detecting device at this year’s ISEF. The device is based on a raman spectrometer, but relies on off-the-shelf components like a laser pointer and an iPod camera to scan tissue for cancer cells. And whereas a raman spectrometer is the size of a small car and can cost upwards of $100,000, his fits in the palm of your hand and costs about $15.

Talking with the Prez
Talking with the Prez

Oh, and I should also mention that Jack got to meet President Obama. When I asked what the experience was like, after admitting to being jealous, he told me that the President “loves to talk about science and asks great questions. [And] he has the softest hands!” Who knew? In any case, here’s what he had to tell me about his inspirations, plans, and predictions for the future.

1. What drew you to science and scientific research in the first place?

I have always enjoyed asking questions and thinking about how and why things behave the way they do. The more I learned about a subject, the more deeply I wanted to explore and that led to even more questions. Even when I was 3 I loved building small dams in streams and experimenting with what would happen if I built the dams a certain way and what changes in water flow would occur.

When I entered 6th grade, science fair was required and was very competitive. I was in a charter school and the science fair was really the highlight of the year. Now I did not only love science, but I was highly motivated to do a really good project!

That's him, building is dams.
That’s him, building his dams

2. You’re litmus test for pancreatic cancer was a major breakthrough. How did you come up with the idea for it?

When I was 14 a close family friend who was like an uncle to me passed away from pancreatic cancer. I didn’t even know what a pancreas was so I turned to every teenager’s go-to source of information, Google and Wikipedia, to learn more. What I found shocked me. The 5 year survival rate is just awful, with only about 5.5% of people diagnosed achieving that time period. One reason is that the disease is relatively asymptomatic and thus is often diagnosed when a patient is in an advanced stage of the cancer. The current methods are expensive and still miss a lot of cancers.

I knew there had to be a better way so I started reading and learning as much as I could. One day in Biology class I was half listening to the teacher talk about antibodies while I was reading a really interesting article on carbon nanotubes. Then it hit me: what if I combined what I was reading (single walled carbon nanotubes) with what I was supposed to be listening to (antibodies) and used that mixture to detect pancreatic cancer.

andraka_profileOf course I had a lot of work left to do so I read and read and thought and thought and finally came up with an idea. I would dip coat strips of inexpensive filter paper with a mixture of single walled carbon nanotubes and the antibody to mesothelin, a biomarker for pancreatic cancer. When mesothelin containing samples were applied the antibody would bind with the mesothelin and push the carbon nanotubes apart, changing the strips’ electrical properties, which I could then measure with an ohm meter borrowed from my dad.

Then I realized I needed a lab (my mom is super patient but I don’t think she’d be willing to have cancer research done in her kitchen!). I wrote up a proposal and sent it out to 200 professors working on anything to do with pancreatic research. Then I sat back waiting for the acceptances to roll in.

I received 199 rejections and one maybe, from Dr Maitra of Johns Hopkins School of Medicine. I met with him and he was kind enough to give me a tiny budget and a small space in his lab. I had many many setbacks but after 7 months, I finally created a sensor that could detect mesothelin and thus pancreatic cancer for 3 cents in 5 minutes.

ISEF2012-Top-Three-Winners3. What was your favorite thing about the 2012 Intel International Science and Engineering Fair – aside from winning, of course?

My brother had been a finalist at Intel ISEF and I attended as an observer. I was blown away by the number and quality of the projects there and loved talking to the other finalists. It became my dream to attend Intel ISEF as well. My favorite thing about getting to be a finalist was the sense that I was among kids who were as passionate about math and science as I was and who were curious and creative and who wanted to innovate and push their limits. It felt like I had found my new family! People understood each other and shared ideas and it was so exciting and inspiring to be there with them, sharing my ideas as well!

4. What was the inspiration behind you and your colleagues coming together to start “Generation Z”?

I met some other really interesting kids at Intel ISEF who were making huge advances. I am fascinated by creating ways to diagnose diseases and pollutants. We started talking and the subject of the X Prize came up. We thought it would be a fun challenge to try our hand at it! We figure at the very least we will gain valuable experience working on a team project while learning more about what interests us.

5. How did people react to your smartphone-sized cancer detector at this years ISEF?

Of course people came over to see my project because of my success the previous year. This project was not as finished as it could have been because I was so busy traveling and speaking, but it was great to see all my friends and make new ones and explain what I was aiming for.

Tricorder X6. Your plans for a tricorder that will compete in Tricoder X are currently big news. Anything you can tell us about it at this time?

My team is really coming together. Everyone is working on his/her own piece and then we often Skype and discuss what snags we are running up against or what new ideas we are thinking about.

7. When you hear the words “The Future of Medicine”, what comes to mind? What do you think the future holds?

I believe that the future of medicine is advancing so fast because of the internet and now mobile phones. There are so many new and inexpensive diagnostic methods coming out every month. Hopefully the open access movement will allow everyone access to the knowledge they need to innovate by removing the expensive pay walls that lock away journal articles and the important information they contain from people like me who can’t afford them.

Tricorder X_prizeNow kids don’t have to depend on the local library to have a book that may be outdated or unavailable. They can turn to the internet to connect with MOOCs (Massive Open Online Courses), professors, forums and major libraries to gain the information they need to innovate.

8. What are your plans for the future?

I plan to finish my last 2 years of high school and then go to college. I’m not sure which college or exactly what major yet but I can’t wait to get there and learn even more among other people as excited about science as I am.

9. Last question: favorite science-fiction/fantasy/zombie or superhero franchises of all time, and why do you like them?

I like the Iron Man movies the best because the hero is an amazing scientist and engineer and his lab is filled with everything he would ever need. I wonder if Elon Musk has a lab like that in his house!!

Yeah, that sounds about right! I’m betting you and Musk will someday be working together, and I can only pray that a robotic exoskeleton is one of the outcomes! And I would be remiss if I didn’t point out that we had a Superhero Challenge here on this site, where we designed our own characters and created a fictional crime-fighting league known as The Revengers! We could use a scientifically-gifted mind in our ranks, just saying…

Thank you for coming by and sharing your time with us Jack! I understood very little of what you said, but I enjoyed hearing about it. I think I speak for us all when I say good luck with all your future endeavors, and may all your research pursuits bear fruit!

The Future of Medicine: Engineered Viruses, Nanoparticles and Bio-Absorbable Circuits

medtechThe future that is fast approaching us is one filled with possibilities, many of which were once thought to be the province of science fiction. Between tricorders and other new devices that can detect cancer sooner and at a fraction of the cost, HIV vaccines and cures, health monitoring tattoos and bionic limbs, we could be moving into an age where all known diseases are curable and physical handicaps will be non-existent.

And in the past few months, more stories have emerged with provide hope for millions of people living with diseases, injuries and disabilities. The first came just over three weeks ago from University of California, Berkley, where researchers have been working with an engineered virus which they claim could help cure blindness. As part of a gene therapy program, this treatment has been shown to effectively correct a rare form of inherited blindness.

virus-sight1For the past six years, medical science has been using adeno-associated viruses (AAV) as part of a gene therapy treatment to correct inherited retinal degenerative disease. However, the process has always been seen as invasive, since it involves injected the AAVs directly into a person’s retina with a needle. What’s more, the rpocess has shown itself to be limited, in that the injected virus does not reach all the retinal cells that need repair.

But as Professor David Schaffer, the lead researcher on the project, stated in an interview with Science Translational Medicine:

[D]octors have no choice because none of the gene delivery viruses can travel all the way through the back of the eye to reach the photoreceptors – the light sensitive cells that need the therapeutic gene.

Building on this and many more years of research, Prof David Schaffer and his colleagues developed a new process where they generated around 100 million variants of AAV and then selected five that were effective in penetrating the retina. They then used the best of these, a strain known as 7m8, to transport genes to cure two types of hereditary blindness on a group of mice.

virus-sightIn each case, the engineered virus delivered the corrective gene to all areas of the retina and restored retinal cells nearly to normal. But more importantly, the virus’ ability to penetrate the retina on its own makes the process far less invasive, and will likely be far more cost-effective when adapted to humans. And the process is apparently very convenient:

[W]e have now created a virus that you just inject into the liquid vitreous humor inside the eye and it delivers genes to a very difficult-to-reach population of delicate cells in a way that is surgically non-invasive and safe. It’s a 15-minute procedure, and you can likely go home that day.

Naturally, clinical trials are still needed, but the results are encouraging and Professor Schaffer indicated that his team are busy at work, now collaborating with physicians to identify the patients most likely to benefit from this gene-delivery technique.

nanoparticles_miceNext up, there was the announcement back at the end of May that researchers from North Carolina State and University of North Carolina Chapel Hill had found yet another medical use for nanoparticles. In there case, this consisted of combating a major health concern, especially amongst young people today: diabetes.

In a study that was published in the Journal of Agricultural and Food Chemistry, the collaborating teams indicated that their solution of nanoparticles was able to monitor blood sugar levels in a group of mice and released insulin when their sugar levels got too high. Based on the results, the researchers claim that their method will also work for human beings with type 1 diabetes.

image descriptionEach of the nanoparticles have a core of insulin that is contained with a degradable shell. When glucose levels in the blood reach high concentrations spike, the shell dissolves, releasing insulin and lowering the subject’s blood sugar. The degradable nano-network was shown to work in mice where a single injection kept blood glucose levels normal for a minimum of 10 days.

While the exact cause of this kind of diabetes is unknown, the effects certainly are. Patients living with this genetically-acquired form of the disease require several shots of insulin a day to keep their blood sugar levels under control. And even then, blindness, depression and even death can still result. What’s more, if the insulin shots are specifically calculated for the individual in question, side-effects can occur.

???????????????????????????????Hence the genius behind this new method. Not only would it relieve people who have type 1 diabetes from constantly injecting themselves, it would also remove the need to monitor their own blood sugar levels since the nanoparticles would be controlling them automatically.

In a study published recently in the Journal of Agricultural and Food Chemistry, Zhen Gu, lead author of the study claimed that the technology functions essentially the same as a pancreas. Hence another benefit of the new method, in that it could make pancreatic transplants – which are often necessary for patients with diabetes – unnecessary.

biocircuitsAnd last, but certainly not least, comes from the University of Illinois where John Rogers are developing a series of bio-absorbable electronic circuits that could help us win the war on drug-resistant bacteria. As part of a growing trend of biodegradable, flexible electronic circuits that operate wirelessly, fighting “superbugs” is just one application for this technology, but a very valuable one.

For some time now, bacteria that is resistant to antibiotics has been spreading, threatening to put the clock back 100 years to the time when routine, minor surgery was life-threatening. Some medical experts are warning that otherwise straightforward operations could soon become deadly unless new ways to fend off these infections are found. And though bacteria can evolve ways of evading chemical assaults, they are still vulnerable to direct assault.

electronics_dissolvingThis is how the new bio-absorbable circuits work: by heating up the virus. Each circuit is essentially a miniature electric heater that can be implanted into wounds and powered wirelessly to fry bacteria during healing before dissolving harmlessly into body fluids once their job is done. While this might sound dangerous, keep in mind that it takes only a relatively mild warming to kill bugs without causing discomfort or harm to surrounding tissues.

To fashion the circuits, Rogers and his colleagues used layers of utra-thin wafers and silk, material so thin that they disintegrate in water or body fluids or (in the case of silk) are known to dissolve anyway. For the metal parts, they used extra-thin films of magnesium, which is not only harmless but in fact an essential nutrient. For semiconductors, they used silicon membranes 300 nanometres thick, which also dissolve in water.

In addition to deterring bacteria, Rogers says that implantable, bio-absorbable RF electronics could be used to stimulate nerves for pain relief, and to stimulate bone re-growth, a process long proven to work when electrodes are placed on the skin or directly on the bone. Conceivably they could also be used to precisely control drug release from implanted reservoirs.

In other words, this is just the beginning. When it comes to the future of medicine, just about any barrier that was once considered impassable are suddenly looking quite porous…