The Future of Medicine: Brain Scan Databanks

AI_picCloud computing and the internet are having a profound effect on the field of medicine. As more and more patients have their records digitized and posted in online medical sources, doctor’s are able to better track patient histories, conduct referrals, and make speedier diagnoses. And now, doctors at John Hopkins University are working on a cloud-computing project specifically for children’s brain scans.

By collecting and categorizing thousands of MRI scans from kids with normal and abnormal brains, they say the resulting database will give physicians a sophisticated, “Google-like” search system to help find similar scans as well as the medical records of those children. Such a system could help not only enhance the diagnosis of brain disorders, but the treatment as well, maybe even before clinical symptoms are obvious to the naked eye.

Miller_JohnHopkinsMichael I. Miller, a lead investigator on the project who also heads up the university’s Center for Imaging Science, said in a news release:

If doctors aren’t sure which disease is causing a child’s condition, they could search the data bank for images that closely match their patient’s most recent scan. If a diagnosis is already attached to an image from the data bank, that could steer the physician in the right direction. Also, the scans in our library may help a physician identify a change in the shape of a brain structure that occurs very early in the course of a disease, even before clinical symptoms appear. That could allow the physician to get an early start on the treatment.

Susumu Mori, a radiology professor at the Johns Hopkins School of Medicine and co-lead investigator on what he calls the “biobank,” says that a collection of brain scans of this size will also help neuroradiologists and physicians identify specific malformations far faster than is currently possible.

brain-activityMori has spent the past four-plus years working on a clinical database of more than 5,000 whole brain MRI scans of children who’ve come through Johns Hopkins. This project involved indexing anatomical data on 1,000 structural measurements in 250 brain regions that were ultimately sorted into 22 brain disease categories, including infections, psychiatric disorders, epilepsy, and chromosomal abnormalities.

The project, which was made possible by a three-year $600,000 grant from the National Institutes of Health, is still in its pilot stage and available only to physicians and patients within the Johns Hopkins medical system. But the researchers say it could open up and expand to other networks in the coming years. Such an expansion would presumably benefit not only other physicians and patients, but the database itself.

brainscansResearchers are also working on a similar project to collect scans of elderly patients to focus on age-related diseases and neurological disorders. Combined with the pediatric databank, this new brain scan archive will not only help recognize established neurological disorders, but could even possibly help identify and classify new ones as well.

But one of the key words here in anonymous. While cloud computing and patient files may raise the specter of privacy for many, the current project maintains patient confidentially. And one can further assume that voluntary compliance will be maintained as databases like these expand. After all, one does not need to know a patient’s name in order to examine what anomalies their brains exhibit.

And in the meantime, be sure to check out this video of Michael Miller explaining the new brain scan project and computational anatomy in greater detail:


Source:
news.cnet.com

Jack Andraka and I Have a Chat!

photo(1)Folks, today I have a rare privilege which I want to share with you. Not that long ago, I reached out to a certain brilliant mind that’s been making waves in the scientific community of late, a young man who – despite his age – has been producing some life saving technologies and leading his own research team. This young man, despite his busy schedule, managed to get back to me quite quickly, and agreed to an interview.

I am of coarse referring to Jack Andraka, a man who’s medical science credentials are already pretty damn impressive. At the age of 16, he developed a litmus test that was capable of detecting pancreatic cancer, one that was 90% accurate, 168 times faster than current tests, and 1/26,000th the cost. For this accomplishment, he won first place at the 2012 Intel International Science and Engineering Fair (ISEF).

Winning at the 2012 ISEF
Winning at the 2012 ISEF

Afterward, he and the other finalists formed their own research group known as Generation Z, which immediately began working towards the creation of a handheld non-invasive device that could help detect cancer early on. In short, they began working on a tricorder-like device, something for which they hope to collect the Tricorder X PRIZE in the near future.

While this project is ongoing, Andraka presented his own concept for a miniature cancer-detecting device at this year’s ISEF. The device is based on a raman spectrometer, but relies on off-the-shelf components like a laser pointer and an iPod camera to scan tissue for cancer cells. And whereas a raman spectrometer is the size of a small car and can cost upwards of $100,000, his fits in the palm of your hand and costs about $15.

Talking with the Prez
Talking with the Prez

Oh, and I should also mention that Jack got to meet President Obama. When I asked what the experience was like, after admitting to being jealous, he told me that the President “loves to talk about science and asks great questions. [And] he has the softest hands!” Who knew? In any case, here’s what he had to tell me about his inspirations, plans, and predictions for the future.

1. What drew you to science and scientific research in the first place?

I have always enjoyed asking questions and thinking about how and why things behave the way they do. The more I learned about a subject, the more deeply I wanted to explore and that led to even more questions. Even when I was 3 I loved building small dams in streams and experimenting with what would happen if I built the dams a certain way and what changes in water flow would occur.

When I entered 6th grade, science fair was required and was very competitive. I was in a charter school and the science fair was really the highlight of the year. Now I did not only love science, but I was highly motivated to do a really good project!

That's him, building is dams.
That’s him, building his dams

2. You’re litmus test for pancreatic cancer was a major breakthrough. How did you come up with the idea for it?

When I was 14 a close family friend who was like an uncle to me passed away from pancreatic cancer. I didn’t even know what a pancreas was so I turned to every teenager’s go-to source of information, Google and Wikipedia, to learn more. What I found shocked me. The 5 year survival rate is just awful, with only about 5.5% of people diagnosed achieving that time period. One reason is that the disease is relatively asymptomatic and thus is often diagnosed when a patient is in an advanced stage of the cancer. The current methods are expensive and still miss a lot of cancers.

I knew there had to be a better way so I started reading and learning as much as I could. One day in Biology class I was half listening to the teacher talk about antibodies while I was reading a really interesting article on carbon nanotubes. Then it hit me: what if I combined what I was reading (single walled carbon nanotubes) with what I was supposed to be listening to (antibodies) and used that mixture to detect pancreatic cancer.

andraka_profileOf course I had a lot of work left to do so I read and read and thought and thought and finally came up with an idea. I would dip coat strips of inexpensive filter paper with a mixture of single walled carbon nanotubes and the antibody to mesothelin, a biomarker for pancreatic cancer. When mesothelin containing samples were applied the antibody would bind with the mesothelin and push the carbon nanotubes apart, changing the strips’ electrical properties, which I could then measure with an ohm meter borrowed from my dad.

Then I realized I needed a lab (my mom is super patient but I don’t think she’d be willing to have cancer research done in her kitchen!). I wrote up a proposal and sent it out to 200 professors working on anything to do with pancreatic research. Then I sat back waiting for the acceptances to roll in.

I received 199 rejections and one maybe, from Dr Maitra of Johns Hopkins School of Medicine. I met with him and he was kind enough to give me a tiny budget and a small space in his lab. I had many many setbacks but after 7 months, I finally created a sensor that could detect mesothelin and thus pancreatic cancer for 3 cents in 5 minutes.

ISEF2012-Top-Three-Winners3. What was your favorite thing about the 2012 Intel International Science and Engineering Fair – aside from winning, of course?

My brother had been a finalist at Intel ISEF and I attended as an observer. I was blown away by the number and quality of the projects there and loved talking to the other finalists. It became my dream to attend Intel ISEF as well. My favorite thing about getting to be a finalist was the sense that I was among kids who were as passionate about math and science as I was and who were curious and creative and who wanted to innovate and push their limits. It felt like I had found my new family! People understood each other and shared ideas and it was so exciting and inspiring to be there with them, sharing my ideas as well!

4. What was the inspiration behind you and your colleagues coming together to start “Generation Z”?

I met some other really interesting kids at Intel ISEF who were making huge advances. I am fascinated by creating ways to diagnose diseases and pollutants. We started talking and the subject of the X Prize came up. We thought it would be a fun challenge to try our hand at it! We figure at the very least we will gain valuable experience working on a team project while learning more about what interests us.

5. How did people react to your smartphone-sized cancer detector at this years ISEF?

Of course people came over to see my project because of my success the previous year. This project was not as finished as it could have been because I was so busy traveling and speaking, but it was great to see all my friends and make new ones and explain what I was aiming for.

Tricorder X6. Your plans for a tricorder that will compete in Tricoder X are currently big news. Anything you can tell us about it at this time?

My team is really coming together. Everyone is working on his/her own piece and then we often Skype and discuss what snags we are running up against or what new ideas we are thinking about.

7. When you hear the words “The Future of Medicine”, what comes to mind? What do you think the future holds?

I believe that the future of medicine is advancing so fast because of the internet and now mobile phones. There are so many new and inexpensive diagnostic methods coming out every month. Hopefully the open access movement will allow everyone access to the knowledge they need to innovate by removing the expensive pay walls that lock away journal articles and the important information they contain from people like me who can’t afford them.

Tricorder X_prizeNow kids don’t have to depend on the local library to have a book that may be outdated or unavailable. They can turn to the internet to connect with MOOCs (Massive Open Online Courses), professors, forums and major libraries to gain the information they need to innovate.

8. What are your plans for the future?

I plan to finish my last 2 years of high school and then go to college. I’m not sure which college or exactly what major yet but I can’t wait to get there and learn even more among other people as excited about science as I am.

9. Last question: favorite science-fiction/fantasy/zombie or superhero franchises of all time, and why do you like them?

I like the Iron Man movies the best because the hero is an amazing scientist and engineer and his lab is filled with everything he would ever need. I wonder if Elon Musk has a lab like that in his house!!

Yeah, that sounds about right! I’m betting you and Musk will someday be working together, and I can only pray that a robotic exoskeleton is one of the outcomes! And I would be remiss if I didn’t point out that we had a Superhero Challenge here on this site, where we designed our own characters and created a fictional crime-fighting league known as The Revengers! We could use a scientifically-gifted mind in our ranks, just saying…

Thank you for coming by and sharing your time with us Jack! I understood very little of what you said, but I enjoyed hearing about it. I think I speak for us all when I say good luck with all your future endeavors, and may all your research pursuits bear fruit!