For decades, bone marrow transplants have been used for the treatment of cancer, particularly lymphoma, leukemia, and multiple myeloma. However, after three years of receiving transplants, two Australian men who were previously diagnosed with HIV have shown no signs of the AIDS virus. Moreover, one of the patient’s is the first recorded case of clearing the virus without the presence of a rare anti-HIV gene in the donor marrow.
The two patients, a 53-year-old and 47-year-old male, were diagnosed with leukaemia and lymphoma respectively at St Vincent’s Hospital in Sydney, Australia, which has been working in partnership with the University of New South Wales’ Kirby Institute. To date, there have been several reported cases of patients cleared of HIV that were related to bone marrow transplants, but this is something new entirely.
Timothy Ray Brown, a US citizen, was treated in 2007/8 for leukaemia with transplanted stem cells from a donor with the CCR5 delta32 mutation – which is resistant to HIV – and was reported clear of the virus. Afterward, Brown stopped taking his antiretroviral medication and remained HIV-free. In 2012, two other US patients were treated with marrow that did not contain the mutation and initially tested clear. But when they ceased taking antiretroviral medication, the virus returned.
The Australian lymphoma patient, treated in 2010, did receive one transplant of bone marrow that contained one of two copies of a gene that is possibly resistant to HIV. However, the leukaemia patient, treated in 2011, received donor marrow with no resistive gene. Both patients remain on antiretroviral medication as a precaution, since the virus may be in remission rather than completely cured.
The next step is to figure out why the body responds to a bone marrow transplant in a way that makes the virus retreat. One possible explanation is that the body’s immune response to the foreign cells of the transplant causes it to fight harder against HIV. This is because, while bone marrow transplant seems to be the most effective means of clearing the AIDS virus to date, it is not an acceptable risk for patients whose lives aren’t already endangered by bone cancer.
As Professor David Cooper, the study’s senior author and the director of the UNSW Kirby Institute, explained:
We’re so pleased that both patients are doing reasonably well years after the treatment for their cancers and remain free of both the original cancer and the HIV virus… The procedure itself has an up to 10 percent mortality rate. But you take that risk in someone with leukemia or lymphoma because they’re going to die without it, and the transplantation will result in cure. For someone with HIV, you would certainly not transplant them when they have an almost normal life span with standard antiretroviral therapy.
The team of researchers plans to replicate the immune response to bone marrow transplantation in a laboratory setting in the hope of devising a less invasive and less dangerous immunotherapy against the virus. They will also be studying the two patients to help figure out where in the body the virus is hiding. As Cooper said, the big scientific question in HIV/AIDS research today and the key to finding the cure is learning where the remains of the virus is hides.We still don’t know why these patients have undetectable viral loads. One theory is that the induction therapy helps to destroy the cells in which the virus is hiding and that any remaining infected cells are destroyed by the patient’s new immune system.. We need more research to establish why and how bone marrow transplantation clears the virus. We also want to explore the predictors of sustained viral clearance and how this might be able to be exploited without the need for bone marrow transplantation.
The team will be presenting their research 19 July 2014 at the 20th International AIDS Conference in Melbourne, Australia. There, they will be amongst such high-profile speakers as former President Bill Clinton, UNAIDS Executive Director Michel Sidibé and artist and activist Sir Bob Geldof, as well as thousands of the world’s top AIDS researchers, community leaders, people living with HIV and policy-makers at AIDS 2014.
Source: cnet.com, aids2014.com
Such ideas did inform Kim Stanley Robinson’s seminal novel Red Mars, where an international crew flew to the Red Planet and established the first human settlement that begins the terraforming process. But if international cooperation proves too difficult, perhaps a collaboration between commercial space agencies and federal ones could work. I can see it now: the Elon Musk Martian Dome; the Richard Branson Habitat; or the Gates colony…
At the time of the initial announcement in January, Google said its prototypes were able to take one glucose reading per second and that they was investigating ways for the device to act as an early warning system for the wearer should glucose levels become abnormal. All that was needed was a partner with the infrastructure and experience in the medical industry to see the prototypes put into production.
As Butow explained, it’s all about taking the next step in the development of the internet as we know it:
More experienced women are encouraged to teach classes, and the Academy already boasts a variety of events, ranging from hackathons, makerfests, code getaways and study tours. The team is already organising the very first study tour, hoping to take Australian women to visit global startup hotspots such as Silicon Valley and Tel Aviv. And though women are the focus, men are welcome too, as long as they attend with a girl geek and are willing to lend a helping hand.
With all the publicity New Zealand has been getting from the Lord of the Rings and Hobbit franchises, both of which use the scenic land as the setting of Middle Earth, it was only a matter of time before the country’s air carrier began pimping it for all it was worth! Entitled “An Unexpected Briefing”, this safety briefing video is being used by New Zealand Air to both entertain and inform their passengers.
The NASA.gov website will host features, videos, and historic images and audio clips that highlight the Apollo 11 anniversary, as well as the future of human spaceflight. You can find it all by clicking 
Previous versions, using heart muscle tissue, were also able to “walk” but were not controllable, as heart tissue contracts constantly of its own accord. Spinal muscle, by contrast, responds to external electrical stimuli and provide a range of a range of potential uses. These include bio-robots being able to operate inside the body in medical applications, or being used outdoors in environmental services.
They’re also looking at integrating neurons to steer the tiny bots around, either using light or chemical gradients as a trigger. This would be a key step toward being able to design bots for a specific purpose. As Bashir said:
In addition, Bertassoni claims that the ultimate aim of the research is for patients to be able to walk into a hospital and have a full organ printed with all the cells, proteins and blood vessels in the right place:
Stories by Williams 