The Future is Here: DARPA’s Nervous System Implants

Hard on the heels of their proposed BRAIN initiative – a collaborative research initiative to map the activity of every neuron in the human brain – DARPA has announced a bold new program to develop tiny electronic implants that will be able to interface directly with the human nervous system to control and regulate many different diseases and chronic conditions, such as arthritis, PTSD, Crohn’s disease, and depression.

The program, called ElectRx (pronounced ‘electrics’), ultimately aims to replace medication with “closed-loop” neural implants which monitor the state of your health and then provide the necessary nerve stimulation to keep your organs and biological systems functioning properly. The work is primarily being carried out with US soldiers and veterans in mind, but the technology will certainly percolate down to civilians as well.

The ElectRx program will focus the relatively new area of medical therapies called neuromodulation, which seeks to modulate the nervous system to improve neurological problem. Notable examples of this are cochlear implants which restore hearing by modulating your brain’s auditory nerve system, and deep brain stimulation (DBS) which is apparently capable of curing/regulating conditions like depression and Parkinson’s by overriding erroneous neural spikes.

So far, these implants have been fairly large, which makes implantation fairly invasive and risky. Most state-of-the-art implants also lack precision, with most placing the stimulating electrodes in roughly the right area, but which are unable to target a specific bundles of nerves. With ElectRx, DARPA wants to miniaturize these neuromodulation implants so that they’re the same size as a nerve fiber.

This way they can be implanted with a minimally invasive procedure (through a needle) and attached to specific nerve fibers, for very precise stimulation. While these implants can’t regulate every condition or replace every medication (yet), they could be very effective at mitigating a large number of conditions. A large number of conditions are caused by the nervous system misfiring, like inflammatory diseases, brain and mental health disorders.

Currently, a variety of drugs are used to try and cajole these awry neurons and nerves back in-line by manipulating various neurotransmitters. However, the science behind these drugs is not yet exact, relying heavily on a trial-and-error approach and often involving serious side-effects. Comparatively, an electronic implant that could “catch” the misfire, cleans up the signal, and then retransmits it would be much more effective.

As DARPA’s Doug Weber explained:

The technology DARPA plans to develop through the ElectRx program could fundamentally change the manner in which doctors diagnose, monitor and treat injury and illness. Instead of relying only on medication — we envision a closed-loop system that would work in concept like a tiny, intelligent pacemaker. It would continually assess conditions and provide stimulus patterns tailored to help maintain healthy organ function, helping patients get healthy and stay healthy using their body’s own systems.

Despite requiring a lot of novel technological breakthroughs, DARPA is planning to perform human trials of ElectRx in about five years. The initial goal will be improving the quality of life for US soldiers and veterans. And while they have yet to announce which conditions they will be focusing on, it is expected that something basic like arthritis will be the candidate – though there are expectations that PTSD will become a source sooner other than later.

And this is just the latest neurological technology being developed by DARPA. Earlier in the year, the agency announced a similar program to develop a brain implant that can restore lost memories and experiences. A joint fact sheet released by the Department of Defense and the Veteran’s Association revealed that DARPA also secured 78 million dollars to build the chips as part of the government’s Brain Research through Advancing Innovative Neurotechnologies (BRAIN) program.

While DARPA’s ElectRx announcement is purely focused on the medical applications of miniature neural implants, there are of course a variety of other uses that might arise from elective implantation – for soldiers as well as civilians. With a few well-placed implants in a person’s spine, they could flip a switch and ignore any pain reported by your limbs, allowing them to withstand greater physical stress or ignore injuries.

Implants placed in muscle fibers could also provide added electrostimulation to provide extra boosts of raw muscle power. And With precision-placed implants around the right nerve fibers, people could gain manual control of their organs, allowing them to speed up or slow down their hearts, turbo-charge their livers, or tweak just about any other function of their bodies.

The age of the Transhuman looms, people!

Source: extremetech.com, motherboard.vice.com, darpa.mil

The Future is Here: First Brain-to-Brain Interface!

In a first amongst firsts, a team of international researchers have reported that they have built the first human-to-human brain-to-brain interface; allowing two humans — separated by the internet — to consciously communicate with each other. One researcher, attached to a brain-computer interface (BCI) in India, successfully sent words into the brain of another researcher in France, who was wearing a computer-to-brain interface (CBI).

In short, the researchers have created a device that allows people to communicate telepathically. And it’s no surprise, given the immense amount of progress being made in the field. Over the last few years, brain-computer interfaces that you can plug into your computer’s USB port have been commercially available. And in the last couple of years we’ve seen advanced BCIs that can be implanted directly into your brain.

Creating a brain-to-brain connection is a bit more difficult though, as it requires that brain activity not only be read, but inputted into someone else’s brain. Now, however, a team of international researchers have cracked it. On the BCI side of things, the researchers used a fairly standard EEG (electroencephalogram) from Neuroelectrics. For the CBI, which requires a more involved setup, a transcranial magnetic stimulation (TMS) rig was used.

To break the process down, the BCI reads the sender’s thoughts, like to move their hands or feet, which are then broken down into binary 1s and 0s. These encoded thoughts are then transmitted via the internet (or some other network) to the recipient, who is wearing a TMS. The TMS is focused on the recipient’s visual cortex, and it receives a “1″ from the sender, it stimulates a region in the visual cortex that produces a phosphene.

This is a phenomenon whereby a person sees flashes of light, without light actually hitting the retina. The recipient “sees” these phosphenes at the bottom of their visual field, and by decoding the flashes — phosphene flash = 1, no phosphene = 0 — the recipient can “read” the word being sent. While this is certainly a rather complex way of sending messages from one brain to another, for now, it is truly state of the art.

TMS is somewhat similar to TDCS (transcranial direct-current stimulation), in that it can stimulate regions of neurons in your brain. But instead of electrical current, it uses magnetism, and is a completely non-invasive way of stimulating certain sections of the brain and allowing a person to think and feel a certain way. In short, there doesn’t need to be any surgery or electrodes implanted into the user’s brain to make it happen.

This method also neatly sidestep the fact that we really don’t know how the human brain encodes information. And so, for now, instead of importing a “native” message, we have to use our own encoding scheme (binary) and a quirk of the visual cortex. And even if it does seem a little bit like hard work, there’s no denying that this is a conscious, non-invasive brain-to-brain connection.

With some refinement, it’s not hard to imagine a small, lightweight EEG that allows the sender to constantly stream thoughts back to the receiver. In the future, rather than vocalizing speech, or vainly attempting to vocalize one’s own emotions, people could very well communicate their thoughts and feelings via a neural link that is accommodated by simple headbands with embedded sensors.

And imagine a world where instant messaging and video conferencing have the added feature of direct thought sharing. Or an The Internet of Thoughts, where people can transfer terabytes worth of brain activity the same way they share video, messages and documents. Remember, the internet began as a small-scale connection between a few universities, labs and research projects.

I can foresee a similar network being built between research institutions where professors and students could do the same thing. And this could easily be followed by a militarized version where thoughts are communicated instantly between command centers and bunkers to ensure maximum clarity and speed of communication. My how the world is shaping up to be a science fiction novel!

Sources: extremetech.com, neurogadget.com, dailymail.co.uk

Climate Crisis: Solar-Powered Oasis to Feed Desert Cities

Desertification is one of the biggest threats associated with Climate Change. In places like North Africa and the Middle East, where countries already import up to 90% of their food, the spread of the desert due to increasing temperatures and diminished rainfall is made worse by the fact that cities in the region continue to grow. It’s a situation that is getting more expensive and energy-intensive at a time when things need to be getting more cost-effective and sustainable.

Luckily, a team of architects hopes to create a new agricultural system that could grow and deliver food in the desert. It’s called OAXIS, a conceptual design for a modular set of prefab greenhouses, covered in solar panels, which would extend from a city into the desert. The design of the buildings aims to keep out intense summer heat while the solar panels would power the rest of the building’s infrastructure and send extra energy back into the city.

Conceived by Forward Thinking Architecture, a Barcelona-based firm, the concept seeks to combine flexibility with a minimal carbon footprint. Towards this end, they chose to forgo usual transportation and create a unique conveyor system that would deliver produce without the use of any fossil fuels. The conveyor belt would be underground so it could keep running in a straight line even if buildings were in the way.

Inside the prefab greenhouses, farmers would grow crops like tomatoes, lettuce, and strawberries using a hydroponic system that can reduce fertilizers and pesticides and save 80% of the water used in traditional agriculture, in part by recycling and reusing it. As for where the water comes from, the designers suggest that groundwater could supply the farm’s needs, but many Middle Eastern countries already rely on desalination.

Ideally, desert populations would be small enough that the region’s sparse rainfall could support local crops. But that’s not the reality. In addition, a small part of the recycled water would also be used to create an outdoor garden for education. As architect Javier Ponce, principal and founder of Forward Thinking Architecture, explained:

We thought it cannot only be a farming-only building, it must have a pedagogical approach and have to be attractive in order to become a biodiversity hub which can be visited by the local people and visitors… The cities should be smaller, denser, and compact, but this is not the current situation for some of the Arabian peninsula cities since they have exponentially grown and attract more people and workers. There has been a rapid urbanization in the area since the middle of the 20th century.

The project, he hopes, could help supply food as climate change makes the situation even more challenging. Already, countries in the worst-affected regions are desperately looking for solutions. For example, Qatar has already invested hundreds of millions in a plan to grow as much local food as possible by 2030. Other countries in the region, like Kuwait, Dubai, Abu Dhabi, Jordan, and the desert-locked Saudi Arabia are expected to follow.

These regions in particular have felt the pressure brought on by the escalating price of importing food. This pressure is exacerbated due to the disappearance of peak oil, which accounted for the vast majority of this region’s wealth. However, the project has farther-reaching implications, as Climate Change threatens to turn much of the world’s arable land into dry, drought-ridden plains.

At the same time, it takes into account the need to reduce reliance on water and fossil-fuels. As our population continues to skyrocket, a smarter and more sustainable use of available resources are always needed. As Ponce explained:

The OAXIS project is an alternative or complementary way to respond to the food insecurity and water scarcity of the region in a self-sufficient way. It aims to help reduce the food imports to feed part of the people in a nearby future based on renewable energies.

And be sure to check out this OAXIS promotional video, courtesy of Forward Thinking Architecture:

Sources: fastcoexist.com, forwardthinkingarchitecture

Immortality Inc: Regrowing Body Parts

Anyone who has ever observed a lizard must not have failed to notice that they are capable of detaching their tails, and then regenerating them from scratch. This propensity for “spontaneous regeneration” is something that few organisms possess, and mammals are sadly not one of them. But thanks to a team of Arizona State University scientists, the genetic recipe behind this ability has finally been unlocked.

This breakthrough is a small part of a growing field of biomedicine that seeks to improve human health by tampering with the basic components (i.e. our DNA). The research, which was funded by grants from the National Institutes of Health and Arizona Biomedical Research Commission, also involved scientists from the University of Arizona College of Medicine, Translational Genomic Research Institute, and Michigan State University.

According to Prof. Kenro Kusumi, lead author of a paper on the genetic study, lizards are the most closely-related animals to humans that can regenerate entire appendages. They also share the same genetic language as us, so it’s theoretically possible that we could do what they do, if only we knew which genes to use and in what amounts. As Kusumi explains in the paper, which was published Aug. 20 in the journal PLOS ONE. :

Lizards basically share the same toolbox of genes as humans. We discovered that they turn on at least 326 genes in specific regions of the regenerating tail, including genes involved in embryonic development, response to hormonal signals, and wound healing.

Other animals, such as salamanders, frog tadpoles, and fish, can also regenerate their tails. During tail regeneration, they all turn on genes in what is called the ‘Wnt pathway’ — a process that is required to control stem cells in many organs such as the brain, hair follicles and blood vessel. However, lizards have a unique pattern of tissue growth that is distributed throughout the tail.

It takes lizards more than 60 days to regenerate a functional tail — forming a complex regenerating structure with cells growing into different tissues at a number of sites along the tail. According to Katsumi, harnessing this would be a boon for medicine for obvious reasons:

Using next-generation technologies to sequence all the genes expressed during regeneration, we have unlocked the mystery of what genes are needed to regrow the lizard tail. By following the genetic recipe for regeneration that is found in lizards, and then harnessing those same genes in human cells, it may be possible to regrow new cartilage, muscle or even spinal cord in the future.

The researchers also hope their findings will also help repairing birth defects and treating diseases such as arthritis. Given time, and enough positive results, I think it would be fair to expect that Google’s Clinical Immortality subsidiary – known as Calico – will buy up all the necessary rights. Then, it shouldn’t be more than a decade before a gene treatments is produced that will allow for spontaneous regeneration and the elimination of degenerative diseases.

The age of post-mortal is looming people. Be scared/enthused!

Sources: kurzweil.net, gizmag.com

Ending Parkinsons: Wearables and Cloud Storage

Behind Alzheimer’s, Parkinson’s disease is the second-most widespread neurodegenerative brain disorder in the world, and affects one out of every 100 people over the age of 60. After first being described in 1817 by Dr. James Parkinson, treatment and diagnosis have barely changed. Surgery, medications, and management techniques can help relieve symptoms, but as of yet, there is no cure.

In addition, the causes are not fully understood and appear to vary depending on the individual. But measuring it is often a slow process that doesn’t generate nearly enough data for researchers to make any significant progress. Luckily, Intel recently teamed up with the Michael J. Fox Foundation to and have proposed using wearable devices, coupled with cloud computing, to speed up the data collection process.

Due to the amount of variables involved in Parkinson’s symptoms — speed of movement, frequency and strength of tremors, how it affects sleep, and so on — the symptoms are difficult and tedious to track. Often, data is accrued through patient diaries, which is a slow process. Intel’s plan, which will involve the deployment of smartwatches, can not only increase the rate of data collection, but detect a much higher volume of variables and frequency than a personal diary could.

It is hopes that they will be able to record 300 observations per second, thus creating a massive amount of data per patient. The use of wearables means that the data can even be reported and monitored by researchers and doctors in real time. Later this year, the MJFF is even planning on launching a mobile app that adds medication intake monitoring and allows patients to record how they feel, making personal diaries easier to create and share.

In order to collect and manage the data, it will be uploaded to a cloud storage data platform, and has the ability to notice changes in the data in real time. This allows researchers to track the changes in patient symptoms and share from a large field of data to better spot common patterns and symptoms. In the end, its not quite a cure, but it should help speed up the process of finding one.

Wearable technology, cloud computing and wireless data monitoring are the hallmarks of personalized medicine, which appears to be the way of the future. And while the concept of metadata and keeping medical information in centralized databases may make some nervous (as it raises certain privacy issues), keeping it anonymous and about the symptoms should lead to a speedy development of treatments and ever cures.

And be sure to check out this video from the intelnewsroom, explaining the collaboration in detail:

Source: extremetech.com

Settling Mars: The Mars Base Challenge 2014

Life on Mars can’t become a reality without some serious design concepts and engineering. And that’s why Thingiverse, in cooperation with NASA’s Jet Propulsion Laboratory, conduct the Makerbot Mars Base Challenge every year. Taking Mars’ extreme conditions into consideration, people are tasked with designing a utilitarian Mars base that can withstand the elements and make settlers feel at home.

The competition opened on May 30th and received some 227 submissions. The challenge brief asked entrants to take into account the extreme weather, radiation levels, lack of oxygen and dust storms when designing their Martian shelters. And the winning entries will each be awarded a MakerBot Replicator 2 Desktop 3D Printer in order to help them fully explore their designs for Martian abodes.

And although the applicants did not always nail the science, their designs have a novelty that has not been seen in some time. This can especially be seen in with this years finalists, which included a design for a Martian pyramid, a modular beehive and a three-tiered Acropolis.

The Thingiverse community appears to have been hugely supportive, printing out the designs themselves and offering handy hints in the comment section beneath each entry. Some were dismissed for being impractical; for example, those that would be immediately flattened or kill all of its inhabitants if it were installed on the Martian surface. But one designer, Noah Hornberger, points out:

A toy car does not need fuel because it runs on the imagination of the child who drives it around. So it seems to me that I’m driving my toy car at full speed and you are here telling me what kind of fuel and oil it needs to run. I would rather leave the physics to the right people.

Luckily, that’s what NASA is on hand for – to ensure that it’s not just the mathematicians and engineers that have an interest or a say in our Martian future, but to make sure those designs and dreams that come from the public meet the basic scientific and engineering requirements. Bringing together inspired ideas and realistic needs, here’s how this year’s finalists measured up.

This Mars structure is designed with resource consumption and allocation in mind, and also takes into account that the majority of activity would be taking place inside the structure rather than outside. As its creator, Valcrow. explained:

High traffic rooms all have ample natural Martian light to help with the crews extended isolation and confinement… This design focuses on looping essential systems into as many multi-functional roles as possible to ensure that the very limited resources are used and reused as much as possible.

This includes food created through a sustainable aquaponics system which would sit at the top of the pyramid, where it can get some light. A mirror-based series of solar panels will be responsible for collecting energy, with a nuclear generator for backup, and water would be stored near the main power center so that it heats up. The whole thing is inspired by the Pyramid of Giza, but unlike that beauty it can be reconfigured for science or engineering tasks and experiments.

This second design, known as the Queen B because of its modular beehive configuration, comes with all the mod cons and home comforts you might expect on Earth – a kitchen, two bathrooms, a garden, and a 3D print lab and decompression room. Its creator, Noah Hornberger, chose a flat-panelled, low-level design that would be cheap and easy to build and allow for less heat energy to be lost. The hexagon shape was chosen for its durability and ability to form modular designs.

Depleted uranium would be used to create laminated panels that would shield out the elements, but would need to be sandwiched between other materials to make it safe for the occupants. An exothermic chemical reactor would meanwhile be used to heat an underground water container, which will provide heat for the basecamp. Excess steam could also power generators to supplement solar power.

Speaking on behalf of his creation, Hornberger said:

I have extrapolated on the idea of a fully functional apartment on Mars with all the modern amenities fitted inside 16-foot-diameter hexagons. I think that to present Mars life to people and actually make it appealing to the public it needs to feel like home and reflect the lifestyle trends of Earth living.

And last, but not least, there’s the Mars Acropolis – a design that blends materials used here on Earth to create a classic futurist design that looks like it would be at home in the classic Fritz Lang film. Concrete, steel and Martian soil help form the outer wall that protects the population, while carbon fibre, stainless steel, aluminium and titanium would be used to build the main body.

Three greenhouses contain the vegetation and help filter the air and produce oxygen, and there are decompression chambers at the entrance. On level two, residents can park their shuttles before entering the living quarters and labs, while level three acts as the nerve center – with flight operators and observation posts. It’s joined by a huge water reservoir that flows to the first level for purification.

Designer Chris Starr describes the layout as follows:

The structure serves as a mass research facility, to explore and develop means for additional colonization of the planet. Due to the water vapour contained in the Martian atmosphere, that vapour can be harnessed into usable liquid water, where the condensation is collected from the water vapour, which is filtered back into the reservoir.

In all cases, the designs draw attention to the fact that any structures intended for life on Mars will have to achieve a balance between resource management, comfort and entertainment, and security against the elements. At this point, there’s no telling exactly what a Martian settlement will look like; but as always, the truth will likely be stranger than fiction. To see more designs that made it to the Mars Base Challenge this year, check out Thingiverse’s website.

Sources: wired.co.uk, thingiverse.com

Cyberwars: The Month of Cyberattacks

The month of August has been a busy time for online security specialists, due to numerous cyberattacks being reported close to each other. First came word that supermarket chain Supervalu had been hacked, followed by news of security breaches at a largest American medical group, the Nuclear Regulatory Commission and then the UPS Store. In all cases, the intrusions led to the theft of millions of users’ personal data.

The worst of the lot appears to have been the massive cyberattack on Community Health Systems, one of the largest hospital chains in the US that oversees 206 hospitals in 29 states. According to the company, the intrusion led to stolen Social Security numbers, patient names, addresses, birth dates and telephone numbers of some 4.5 million patients. And as usual, the attack is believed to have had the backing of a foreign government.

This is the largest known attack to involve hospital patient information since the US government began tracking these types of data breaches in 2009. According to Elysium Digital data security expert Joseph Calandrino:

One possible goal of this attack is to facilitate future targeted attacks. The type of data that was stolen from the hospital system is often used to verify a person’s identify. The exposure of this data creates a risk that the hackers could leverage it to gain access to other accounts and information.

As is so often the case these days, it is believed the cyberattack originated in China. Security firm Mandiant, which investigated the breach in April and June, said the hackers belong to a group that targets crucial infrastructure, such as defense, engineering, financial services, and health care companies. It’s unclear if these hackers are affiliated with the Chinese government.

Various security experts have long accused China of waging a cyberwar on US government and private company websites. For example, a report that was released by Mandiant back in 2013 linked Unit 61398 of the China’s People’s Liberation Army to a large number of cyberattacks on US soil. However, the Chinese government has flatly denied that it is involved in cyber-espionage or hacking.

Community Health Systems has since reported that it stopped the cyberattack by removing the malicious software used by the hackers and is notifying its patients of the breach. It has also been reported that the hack may have been facilitated by the Heartbleed bug, a flaw in OpenSSL that hackers use to exploit to obtain encrypted data. The timing certainly seems apt, as the bug was revealed back in April and the attack took place between April and June.

However, this was were merely one of several breaches that took place over the past few months. In addition to the CHS, UPS, and numerous major outlets, cybersecurity firm Hold Security identified what was arguably the largest known data breach in history earlier this month. In this attack, the Russian cybergang Cybervor allegedly stole 1.2 billion username and password combinations and more than 500 million email addresses.

With these latest attacks, it appears that large-scale security breaches carried out by individual hackers and sponsored by nation-states is becoming the new normal. And as these kinds of attacks become more common, cybersecurity experts are concerned that people may suffer from “alert fatigue”, where they will basically cease caring about and not be aware of breaches that affect them.

In addition, security experts would like people to keep in mind that there is a difference between a spike in activity and reporting on activity. Much like the problems of violence, teen sex and crime rates, there is likely a gap between an actual increase and the perception of one. As Lillian Ablon, a researcher for the RAND Corporation, explained:

Back during Operation Aurora [in 2009], when Google got hacked, Google coming out [in 2010] was a big step in the industry. Before that, companies didn’t really talk about being breached.

Legally, companies and government agencies are required to report security breaches to the public only when customer data is involved, and only in 47 states. Alabama, New Mexico, and South Dakota lack mandatory reporting laws, and few laws on the books extract penalties when a breach occurs. Still, whatever the magnitude of the number of security breaches, it’s also true that we are living in an increasingly uncertain world when it comes to keeping our data safe.

Naturally, public vigilance is a good policy, but its not exactly a solution. When the hacks at the Nuclear Regulatory Commission, the Community Health Systems, the Cybervor attack, and hack of the DHS, the attacks were suspected of coming from abroad. More and more, attacks are being staged from a location that is far removed from the source, and backed by third parties who are likely unknown.

Security experts believe that the eventual solution will require businesses to rethink how they operate, putting a much bigger emphasis on security. But the consequences of that could have global economic implications, if better security hurts competitiveness. In the short term, it means that customers who do business with companies that suffer security breaches will need to be that much more vigilant.

That means not reusing passwords for multiple accounts, using two-factor authentication when available, and keeping a close eye on bank statements and credit card activity. And as for the breaches themselves, there’s not much you can do except be prepared to hear about more of them, more often. For better or for worse, it is the age we live in, where big data means big data intrusion!

Sources: cnet.com, (2), (3 )

The Future is Here: Cancer Drug Developed by AI

The development of cancer drugs is a costly, expensive, time-consuming process that has a high probability rate of failure. On average, it takes 24 to 48 months to find a suitable candidate and costs upwards of $100 million. And in the end, roughly 95% of all potential drugs fail in clinical trials. Because of this, scientists are understandably looking for a way to speed up the discovery process.

That’s where the anti-cancer drug known as BPM 31510 comes in play. Unlike most pharmaceuticals, it was developed by artificial intelligence instead of a group of researchers toiling away in a lab. Created by biotech company Berg (named after real estate billionaire Carl Berg) the company seeks to use artificial intelligence to design cancer drugs that are cheaper, have fewer side effects, and can be developed in half the time it normally takes.

Towards this end, they are looking to data-driven methods of drug discovery. Instead of generating cancer drugs based on chemical compounds identified in labs, the company compares tissue, urine, and blood samples from cancer patients and healthy patients, generating tens of trillions of data points that are fed into an artificial intelligence system. That system crunches all the data, looking for problems.

BPM 31510, which is the first of Berg’s drugs to get a real-world test, focuses on mitochondria – a framework within cells that’s responsible for programmed cell death. Normally, mitochondria triggers damaged cells to die. When cancer strikes, this process goes haywire, and the damaged cells spread. Berg’s drug, if successful, will be able to restore normal cell death processes by changing the metabolic environment within mitochondria.

Speaking on the subject of the drug, which is now in human-clinical trials, Berg president and co-founder Niven Narain said:

BPM 31510 works by switching the fuel that cancer likes to operate on. Cancer cells prefer to operate in a less energy-efficient manner. Cancers with a high metabolic function, like triple negative breast cancer, glioblastoma, and colon cancer–that’s the sweet spot for this technology.

IBM is also leveraging artificial intelligence in the race to design better cancer treatments. In their case, this involves their much-heralded supercomputer Watson looking for better treatment options for patients. In a trial conducted with the New York Genome Center, Watson has been scanning mutations found in brain cancer patients, matching them with available treatments.

All of these efforts are still in early days, and even on its accelerated timeline, BPM 31510 is still years away from winning an FDA approval. But, as Narain points out, the current drug discovery system desperately needs rethinking. With a success rate of 1 out of 20, their is definitely room for improvement. And a process that seeks to address cancer in a way that is more targeted, and more personalized is certainly in keeping with the most modern approaches to medicine.

Source: fastcoexist.com

News From Space: SpaceX Booster Explodes in Flight

Last week, during a test flight in McGregor Texas, a new space SpaceX Falcon 9 Reusable Development Vehicle 1 (F9R Dev 1) exploded in midair. This three-engine variant of the F9 is the latest in SpaceX’s arsenal of vertical takeoff, vertical landing (VTVL) rockets designed to allow for easy recovery and reuse. Previously, Grasshopper had only used a single Merlin rocket engine; but for this test, a three-engine version of the vehicle was being used.

The F9R Dev 1 is a second-generation test vehicle rocket based on the SpaceX Grasshopper. Built as part of SpaceX’s program to develop a fully reusable launcher system and spacecraft with all components capable of a powered landing, the F9R has lighter, retractable landing legs and is 50 percent longer than the Grasshopper. It made its first flight last April and is capable of flight operations up to 3,000 m (10,000 ft).

This marks the first major failure for SpaceX’s commercial space launch program, and in a statement, SpaceX says the initiated its self-destruct sequence automatically after detecting an anomaly. Nearby residents saw the fireball and local television station KXXV caught the incident on video. From the footage (seen below), the new test rocket is seen going up, turning 90 degrees to horizontal, and then detonating with a rather neat fireball.

Mercifully, no one was harmed (including the local livestock). Following the incident, Elon Musk tweeted that the vehicle “auto-terminated,” but there were no injuries or near-injuries, and that “Rockets are tricky …” SpaceX also released the following statement saying:

Earlier today, in McGregor, Texas, SpaceX conducted a test flight of a three engine version of the F9R test vehicle (successor to Grasshopper). During the flight, an anomaly was detected in the vehicle and the flight termination system automatically terminated the mission.

Throughout the test and subsequent flight termination, the vehicle remained in the designated flight area. There were no injuries or near injuries. An FAA representative was present at all times.

With research and development projects, detecting vehicle anomalies during the testing is the purpose of the program. Today’s test was particularly complex, pushing the limits of the vehicle further than any previous test. As is our practice, the company will be reviewing the flight record details to learn more about the performance of the vehicle prior to our next test.

SpaceX will provide another update when the flight data has been fully analyzed.

In short, SpaceX was attempting something new and exciting and it didn’t quite go as planned. And although it cost them millions of dollars, rocket scientists know from experience that a controlled detonation in the air is far better than an uncontrolled one on the ground. Should a rocket lose control and crash into the Earth, it will detonate all of its unspent fuel and can cause extensive damage and loss of life.

At this point it’s impossible to say what kind of anomaly was experienced by the rocket, but SpaceX is poring over the gigabytes of flight telemetry data to try and find out what went wrong. In the meantime, space enthusiasts are hoping people will remember that mishaps are part of the development process, and that we’ve come very far since the early days of NASA and Project Mercury, where mistakes and deaths were far more common.

And if SpaceX wants to create the world’s first reusable space launch system, and crack the cheap, commercial space travel market wide open, there are going to be a few fireballs along the way. But as long as it’s just the test launches that explode, we should count our blessings. And in the meantime, be sure to check out the footage obtained by KXXV of the failed test flight:

Sources: extremetech.com, gizmodo.com

Tech for the Developing World: Inflatable Incubators

One of the greatest challenges to combating problems in the developing world – like disease and infant mortality – is the fact that the necessary infrastructure and equipment isn’t always available. This is especially the case in war-torn Syria, where premature babies are dying due to a lack of incubating equipment. Hence why James Roberts came up with his Inflatable Incubator, a cheap and easy-to-transport neonatal device.

Designed to look like an accordion-like instrument known as a concertina, each end of the inflatable shell case contains electronics, including a ceramic heater, some fans, a humidifier, and an Arduino computer. The collapsible middle section extends out and can be inflated into a bed. As Roberts explained:

This allows the incubator to fit into a very compact space for storage or transportation, but still offer the same volume of a first world incubator when inflated for the child’s comfort.

The idea came to him after Roberts saw a video about child death in Syrian refugee camps and he decided to develop the idea as part of a final year project at a British university. So far, there are two prototypes: a purely functional clear plastic box that demonstrates the technology, and an “aesthetic” version that shows off what the product will eventually look like. Roberts is now trying to interest charities in adopting the project.

There are already cheap baby-warming products aimed at the developing world, such as the Embrace – a clever sleeping bag that can maintain a 37° C (98° F)temperature for up to four hours. Roberts’s idea has a few extra features, like a humidity sensor, a temperature probe, and LED lights for nighttime use. The design was also entered in this year’s Dyson Awards, an international student design award program that rewards problem-solving ideas.

To Roberts, his invention is not just about offering a solution to a problem that all-too-common in certain regions of the world. It’s also about addressing a technology gap that has existed for far too long. As he explained it:

Neonatal intensive care units have been around since 1922. So why, almost 100 years later is this still a huge problem in some parts of the world? I believe my design helps solve this problem and could allow for certain children to gain a positive start in life, greatly decreasing the numbers of premature child deaths throughout refugee camps.

As always, its a question of access. And making technologies more accessible in the developing world is one of the greatest challenges facing modern researchers and developers.

Source: fastcoexist.com

Stories by Williams

Classic sci-fi books, reviews, and the best of from a dedicated fan and author!

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