Category: News

Coming Soon: A Universal Flu Vaccine?

flu_vaccineScientists have been making great strides in coming up with treatments and cures for illnesses that were previously thought to be incurable. While some of these are aimed at eliminating pandemics that have taken millions of lives worldwide (such as HIV/AIDS) others are aimed at treating the more common – but no less infectious – viruses, like the common flu.

When it comes to the latter, the difficulty is not so much in creating a cure, as it is a cure all. The flu is a virus that is constantly evolving, changing with the seasons and with each host. This requires medical researchers to constantly develop new vaccines year after year to address the latest strain, as well as specialized vaccines to address different  types – i.e. H1N1, swine, avian bird.

flu_vaccine1Luckily, a research team at Imperial College London say they have made a “blueprint” for a universal flu vaccine. Their report appeared in a recent issue of Nature Medicine. In their report, they specified that the key to creating a universal vaccine lies in targeting the core of the virus, rather than its ever-evolving DNA.

Just last year, researchers at the Friedrich-Loeffler Institute in Riems Island, Germany sought to create a similar vaccine that would target the virus’ RNA structure rather than the key proteins found in the DNA. By contrast, the Imperial researchers set about looking into T-cells, the crucial part of the immune system that is thought to be able to recognize proteins in the core.

2009_world_subdivisions_flu_pandemicTheir research began with a series of clinical examinations of the 2009 swine flu pandemic, which was produced by the combining of earlier strains of pig and bird flu. The team then compared levels of one kind of T-cells at the start of the pandemic with symptoms of flu in 342 staff and students at the university. They showed that the higher the levels of the T-cells a patient had, the milder their symptoms were.

Researchers then teased out the specific part of the immune system that offered some pandemic flu protection and which part of the virus it was attacking. from there, They began developing a vaccine that would trigger the production of these cells – known as CD8 T cells. These cells would attack the invading flu virus, ignoring the outer protein structure and focusing on the core which it had encountered before.

Influenza_virus_2008765Prof Ajit Lalvani, who led the study, told the BBC:

It’s a blueprint for a vaccine. We know the exact subgroup of the immune system and we’ve identified the key fragments in the internal core of the virus. These should be included in a vaccine. In truth, in this case it is about five years [away from a vaccine]. We have the know-how, we know what needs to be in the vaccine and we can just get on and do it.

The benefits of such a vaccine would be profound and obvious. While many of us consider the seasonal flu to be an inconvenience, it is important to note that it kills between 250,000 and 500,000 people worldwide each year. While this is a fraction of the total number of deaths attributed to AIDS (1.6 to 1.9 million in 2010, it is still a significant toll. What’s more, new pandemics have the potential to take doctors by surprise and kill large numbers of people.
t-cellHowever, the Imperial College researchers admit that it is generally harder to develop a T-cell vaccine than a traditional one designed to provoke an antibody response. The challenge will be to get a big enough of a T-cell response to offer protection and a response that will last. So while the blueprint is in place, medical researchers still have a long road ahead of them.

Prof John Oxford, of Queen Mary University of London, put it this way:

This sort of effect can’t be that powerful or we’d never have pandemics. It’s not going to solve all the problems of influenza, but could add to the range of vaccines. It’s going to be a long journey from this sort of paper to translating it into a vaccine that works.

AI-fightingfluWhat’s more, there are concerns that a T-cell vaccine would be limited when it comes to certain age groups. Jenner Institute at Oxford University, explains:

Live attenuated influenza vaccines which are given by nasal spray and will be used in children in the UK from this autumn are much better at increasing the number of influenza-specific T cells, but these vaccines only work in young children who haven’t yet had much exposure to influenza virus, so we need an alternative approach for adults.

Interestingly enough, this approach of stimulating the production of T-cells bears a striking resemblance to the work being done at the Vaccine and Gene Therapy Institute at OHSU, where researchers are working towards a vaccine that could also cure HIV. This research also appeared in Nature Medicine last month.

So not only could we be looking at a cure for both HIV and the flu in the near future, we could be looking at the containment of infectious viruses all over the world. As these two cases demonstrate, advances in medical science towards antivirals appear to be tied at the hip.

Sources: bbc.co.uk, gizmodo.com, nature.com

The Amplituhedron: Quantum Physics Decoded

amplutihedron_spanScientists recently made a major breakthrough that may completely alter our perceptions of quantum physics, and the nature of the universe itself. After many decades of trying to reformulate quantum field theory, scientists at Harvard University discovered of a jewel-like geometric object that they believe will not only simplify quantum science, but even challenge the notion that space and time are fundamental components of reality.

This jewel has been named the “amplituhedron”, and it is radically simplifying how physicists calculate particle interactions. Previously, these Interactions were calculated using quantum field theory – mathematical formulas that were thousands of terms long. Now, these interactions can be described by computing the volume of the corresponding amplituhedron, which yields an equivalent one-term expression.

theory_of_everythingJacob Bourjaily, a theoretical physicist at Harvard University and one of the researchers who developed the new idea, has this to say about the discovery:

The degree of efficiency is mind-boggling. You can easily do, on paper, computations that were infeasible even with a computer before.

This is exciting news, in part because it could help facilitate the search for a Grand Unifying Theory (aka. Theory of Everything) that manages to unify all the fundamental forces of the universe. These forces are electromagnetism, weak nuclear forces, strong nuclear forces, and gravity. Thus far, attempts at resolving these forces have run into infinities and deep paradoxes.

gravityWhereas the field of quantum physics has been able to account for the first three, gravity has remained explainable only in terms of General Relativity (Einstein’s baby). As a result, scientists have been unable to see how the basic forces of the universe interact on a grand scale, and all attempts have resulted in endless infinities and deep paradoxes.

The amplituhedron, or a similar geometric object, could help by removing two deeply rooted principles of physics: locality and unitarity. Locality is the notion that particles can interact only from adjoining positions in space and time, while unitarity holds that the probabilities of all possible outcomes of a quantum mechanical interaction must add up to one.

quantum_field_theoryThe concepts are the central pillars of quantum field theory in its original form, but in certain situations involving gravity, both break down, suggesting neither is a fundamental aspect of nature. As Nima Arkani-Hamed – a professor of physics at the Institute for Advanced Study in Princeton, N.J. and the lead author of the new work – put it: “Both are hard-wired in the usual way we think about things. Both are suspect.”

In keeping with this idea, the new geometric approach to particle interactions removes locality and unitarity from its starting assumptions. The amplituhedron is not built out of space-time and probabilities; these properties merely arise as consequences of the jewel’s geometry. The usual picture of space and time, and particles moving around in them, is a construct.

Photon_follow8And while the amplituhedron itself does not describe gravity, Arkani-Hamed and his collaborators think there might be a related geometric object that does. Its properties would make it clear why particles appear to exist, and why they appear to move in three dimensions of space and to change over time. This is because, as Bourjaily put it:

[W]e know that ultimately, we need to find a theory that doesn’t have [unitarity and locality]. It’s a starting point to ultimately describing a quantum theory of gravity.

Imagine that. After decades of mind-boggling research and attempts at resolving the theoretical issues, all existence comes down to a small jewel-shaped structure. I imagine the Intelligent Design people will have a field day with this, and I can foresee it making it into the new season of Big Bang Theory as well. Breakthroughs like this always do seem to have a ripple effect…

Source: simonsfoundation.org

Ending HIV: New Vaccine Holds Promise for a Cure

hiv-aids-vaccineScientists and researchers have been making great strides in the fight against HIV/AIDS in recent years. In addition to developing vaccines that have shown great promise, there have even been some treatments that have been shown to eliminate the virus altogether. And it seems that with this latest development, which was published in Nature earlier this month, there might be a treatment that can double as a cure.

Developed at the Vaccine and Gene Therapy Institute at the Oregon Health and Science University (OHSU), this new vaccine proved successful in about fifty percent of the clinical subjects that were tested, and may be able to cure patients who are currently on anti-retroviral drugs. If successful, this could mean that a preventative vaccine and cure could come in the same package, thus eliminating HIV altogether.

vaccineCurrently, anti-retroviral drugs and HIV vaccine typically aim at improving the immune response of the patient in the long term. However, they are limited in that they can never completely clear the virus from the body. In fact, aside from a very few exceptional cases, researchers have long believed that HIV/AIDS could only be contained, but not completely cured.

The OHSU team, led by Dr. Louis Picker, has been working on its own vaccine for the past 10 years. In that time, their research has shown that an immune response can in fact go beyond containment and systematically wipe the virus out of the body. As with most early vaccine candidates, the study revolves around SIV – a more aggressive virus than HIV that can replicate up to 100 times faster and, unchecked, can cause AIDS in only two years.

HIV_virusPicker and his research team created the vaccine by working with cytomegalovirus (CMV), another virus which is itself persistent, but doesn’t cause disease. In their initial tests, the vaccine was found to generate an immunoresponse very similar to that generated by CMV, where T-cells that can search and destroy target cells were created and remained in the system, consistently targeting SIV-infected cells until the virus was cleared from the body.

For the sake of their clinical trials, simian subjects were used that were infected by the HIV virus. When treated with the team’s vaccine, half of the subjects initially showed signs of infection, but those signs gradually receded before disappearing completely. This sets it apart from other vaccines which also generate an immunoresponse, but one which fades over time.

HIVAccording to Dr. Picker, it is the permanency of the T-cells that allows the immunoresponse to be consistent and slowly eradicate the virus, eventually eliminating it completely from the system. Says Dr. Picker of their trials and the possibilities for the vaccine:

The virus got in, it infected some cells, moved about in various parts of the body, but it was subsequently cleared, so that by two or three years later the monkeys looked like normal monkeys. There’s no evidence, even with the most sensitive tests, of the SIV virus still being there... We might be able to use this vaccine either to prevent infection or, potentially, even to apply it to individuals who are already infected and on anti-retroviral therapy. It may help to clear their infections so ultimately they can go off the drugs.

Currently, Picker and his the team are trying to understand why some of the vaccinated animals did not respond positively, in the hopes of further increasing the efficacy of the vaccine. Once these trials are complete, it could be just a hop, skip and a jump to getting FDA approval and making the vaccine/cure available to the open market.

Cure_for_HIVImagine, if you will, a world where HIV/AIDS is on the decline, and analysts begin predicting how long it will take before it is eradicated entirely. At this rate, such a world may be just a few years away. For those working in the field of medicine, and those of us who are around to witness it all, it’s an exciting time to be alive!

And be sure to enioy this video from OHSU where Dr. Picker speak about their vaccine and the efforts to end HIV:


Sources: gizmag.com, nature.com

Climate Crisis: A Hurricane-Ready New York Waterfront

terreformONE_harborIn addition to causing extensive damage, Hurricane Sandy demonstrated just how woefully prepared people in New York for major storm surges. When the water began rising back in October, due to intense rainfall and wind, there was little in the way to stop it or break in the incoming flow. As such, plans are now being considered for creating a buffer zone to protect the city from future storms.

Mitch Joachim, the co-founder of Terreform ONE, has a rather novel suggestion for how this could be done. Basically, he wants to submerge old Navy ships in the New York Harbor, creating a “riparian buffer zone” that could better handle large volumes of water. This is just one of many projects his company is involved in, which include improving transportation links in Red Hook and Governor’s Island, and ecologically engineering Brooklyn’s Navy Yard.

terreformONE_harbor1According to Joachim, their firm hit on the idea of using ship hulls to create a walkway that rises up from the harbor floor. In addition to providing protection for New Yorkers, he claims it would be cosmetically pleasing as well:

We thought one way to make gabions really quick is to take hulls from ghost fleets, cut them into sections, and then puzzle-fit the geometry together. It allows over time the transformation of that landscape. Over years of sediment building up, you would have environments that privilege humans at certain points of the day. But then as tide changes occur, you would have aqueous environments that privilege other life besides humans. 

Basically, the walkway would help keep rising tides back in the near future, and would serve as a natural habitat once the tides rise and move in to claim them. By cutting the hulls into clam-like shapes, the organization says that New York could restore a diversified structure to its waterfront, slowing the water before it makes land.

terreformONE_harbor2Joachim points out that dumping junk into New York waterways has a long history, much of it constructive in nature. Parts of Manhattan, like Battery Park City, were built on land created artificially from construction waste. And sinking ships is already one means of disposal, for the sake of creating artificial reefs. The only other method is what is known as “ship breaking”, which is far worse.

This methods of retiring ships involves cutting ships up for scrap and then recycling the usable steel parts. This practice is both environmentally unsound and can lead to toxic chemicals leeching into the ocean, which is why the majority of ship breaking operations occur in developing countries, such as Bangladesh, India, China, Pakistan and Turkey.

terreformONE_harbor3So in addition to offering protection to coastal cities that are currently ill-prepared for the worst effects of Climate Change, reusing ships to augment the world’s harbor fronts could also help reduce the environmental stress we place on other coastlines. It’s like repurposing one problem to deal with two more. Quite clever, when you think about it!

Source: fastcoexist.com

Synchronized VR Triggers Out of Body Experiences

Louish.Pixel
“Spirit Levitation: Out of Body Experience” by Loutish.Pixel

An out-of-body experience (OBE) is one of the most mysterious and inexplicable things a human being can endure. But thanks to new science, triggering one may be as easy as getting a person to watch a video of themselves with their heartbeat projected onto it. According to the study, it’s easy to trick the mind into thinking it belongs to an external body and manipulate a person’s self-consciousness by externalizing the body’s internal rhythms.

These findings were made by a team consisting of Dr Jane Aspell – Senior Lecturer in Psychology at Anglia Ruskin University in the UK – and Lukas Heydrich, a Phd Student at the Ecole Polytechnique Fédérale de Lausanne (EPFL) in Switzerland. Together, the two set out to see find how our internal organs contribute to bodily self-consciousness and whether they can be manipulated to induce an OBE.

electrocardiogramThe underlying goal, according to Ruskin, was finding out how our body merges information such as the visual, auditory, and olfactory with information coming from within. How this leads to the perception we call “reality”, and how it could be altered, is what is being studied here for the first time;

If you think about your body, you have several sources of information about it: you can see your hands and legs, you can feel the seat you’re sitting on via vision, you know you are standing upright thanks to your sense of balance etc. There is also a vast number of signals being sent to your brain from inside of your body every second that you are alive: about your heartbeat, your blood pressure, how full your stomach is, what electrolytes are in your blood, how fast you are breathing.

For their experiment, they attached 17 participants to electrocardiogram sensors and had them view videos of their own bodies through virtual reality goggles so that their body appeared to be two meters (6.5 ft) in front of them. Participants were then shown their own heartbeats in the form of a flashing outline around their “body doubles” that pulsed in sync with their own.

outofbody-1After a few minutes, many of the participants reported sensations of being in an entirely different part of the room rather than their physical body and feeling that their “selves” were closer to their virtual doubles. According to the team, this is the first study that clearly shows how visual signals containing information about the body’s internal organs (i.e. heartbeat) can change their perception of themselves. As Aspell put it:

It confirms that the brain is able to integrate visual information with cardiac information. It seems that the brain is very sensitive to patterns in the world which may relate to self – when the flashing was synchronous with the heartbeat this caused changes to subjects’ self-perception.

While it may sound like technologically-inspired mysticism, the research has several medical applications. One option is to help people with distorted views of themselves – i.e. anorexia, bulimia or other perceptual disorders – to connect with their actual physical appearance. Aspell is currently studying “yo-yo” dieters and says she plans to continue investigating how the internal body shapes who we are.

The Swiss National Science Foundation and the Fondation Bertarelli supported the study which is slated for publication in the APS journal Psychological Science.

Source: gizmag.com

News from Space: Curiosity Finds Water!

curiosity_drillsGood news (and bad) from the Red Planet! According to NASA, an examination of the fine-grained soil particles extracted by Curiosity, scientists have concluded that roughly 2 percent of Martian surface soil is made up of water. Though they did not find any traces of organic particles, this latest find confirms that water not only used to exist on the surface of the planet, but can still be found within.

These results bode well for future manned missions to Mars, wherein astronauts could mine the soil for water and study it to advance their understanding of Mars’ history. The findings, which were published today in the journal Science are part of a five-paper segment that began back in August of 2012 and is dedicated to Curiosity’s ongoing mission.

curiosity_drilling2Laurie Leshin, dean of the School Science at Rensselaer Polytechnic Institute and lead author of the paper, said in a NASA press release:

One of the most exciting results from this very first solid sample ingested by Curiosity is the high percentage of water in the soil.

These tests were conducted using the rover’s Sample Analysis at Mars (SAM), a collection of instruments that includes a gas chromatograph, a mass spectrometer, and a tunable laser spectrometer. The first soil samples were collected back in February when the rover used its drill tool for the first time and created a series of holes that were a little over 6 centimeters (2.5 inches) deep and collected the fine dust that resulted.

SAM_NASAOnce placed into the SAM assembly, the samples were heated to 835 degrees Celsius (1,535 degrees Fahrenheit). The gases that were released – which included significant portions of carbon dioxide, oxygen, and sulfur compounds – were then analyzed. The Mars Science Laboratory (MSL) also noticed that quantities of gaseous carbonite were found, which would suggests the presence of water in the Martian soil.

These positive findings were quite welcome, especially in light of the disheartening news last week that Curiosity has yet to crack the methane mystery. Back in 2003, scientists observed methane plumes coming from the planet, a strong indicator of microbial life, which sent scientific and professional interest in finding life on the red planet soaring.

Since that time, no traces of methane have been found, and it was hoped that Curiosity would finally locate it. However, the lack of methane thus far indicates that the rover has little chance of finding existing microbial life on the planet. But the existence of water in such great quantities in the surface soil brings scientists one step closer to piecing together the planet’s past potential for harboring life.

Curiosity_drillingsPaul Mahaffy, a lead investigator for SAM at NASA’s Goddard Space Flight Center, had this to say:

This work not only demonstrates that SAM is working beautifully on Mars, but also shows how SAM fits into Curiosity’s powerful and comprehensive suite of scientific instruments… By combining analyses of water and other volatiles from SAM with mineralogical, chemical, and geological data from Curiosity’s other instruments, we have the most comprehensive information ever obtained on Martian surface fines. These data greatly advance our understanding surface processes and the action of water on Mars.

Given the renewed interest of late in manned missions to Mars – from nonprofit organizations like Mars One, privatized transportation companies like SpaceX, and the unofficial plans to mount a manned mission to Mars by 2030 by NASA – these findings are reassuring. In addition to providing fuel for hydrogen fuel cells for a return craft, subsurface water will be a boon for settlers and terraformers down the road.

mars-one-brian-versteegLeshin confirmed a cubic foot of soil, as opposed to the tiny sample Curiosity analyzed, could yield nearly 2 pints of condensation when heated. So volunteers who are planning on signing up with Mars One, pack your buckets and stoves and be prepared to do a lot of condensing! And perhaps we can expect “moisture farms” to become the norm on a colonized Mars of the future.

Source: news.cnet.com

News From Space: Manned Europa Mission!

europa-landerWith so much attention focused on Mars in recent years, the other planets of the Solar System have a hard time getting noticed. But lately, Europa has found itself the subject of some interest. In addition to NASA proposing to send a lander there in the near future, a private space organization is thinking of mounting a manned mission to the Jovian moon in search of knowledge and extra-terrestrial life.

This organization is known as Objective Europa, a group made up of  volunteer scientists, conceptual artists, and social-media experts. At the moment, they exist only on the internet. But with time and financial backing, they hope to form a volunteer corps of settlers that would make a one-way trip to Europa and settle the planet while they researched it.

europa-lander-2Inspired by the recent missions to Mars, Objective Europa also believes a mission to this moon would be worthwhile since it is a far better candidate for extra-terrestrial life. Mars, though it is thought to have once hosted life, is a barren and dry world in its present state. Though many are holding out for the discovery of organic particles in the near future, the likelihood of finding any complex organisms larger than a microbe remains extremely low.

Not surprisingly, their group has attracted some big-name celebrities. This includes Kristian von Bengtson, a Danish architect and co-founder of Copenhagen Suborbitals, a nonprofit focused on launching humans into space. Then there’s Michele Faragalli, a rover mobility specialist for a NASA private contractor. Scientist and diver Pierre-Yves Cousteau, son of legendary explorer Jacques Cousteau, is also on the team as an ambassador for the group.

europa_reportCurrently, the group is in Phase 1 of their plan, which is geared towards the gathering of ideas. Towards this end, they have opened up a variety of research topics for discussion on their website. These include investigating the feasibility of a manned mission versus a robotic mission, launch vehicle studies, and cost analysis.Future phases would involve raising funds, and prototyping and testing technology.

What’s more, while they have not yet stated outright how they plan to fund the mission, it seems likely at this point that crowdfunding and sponsorship will come into play. As the goal statement reads on their site:

“Our purpose is to establish the foundation for and carry out a crewed mission to Jovian ice moon Europa through international crowd-research and participation.”

mars-one-brian-versteegIf this is beginning to sound a little bit like Mars One – a similar space organization looking to send volunteers to Mars – then chances are you’ve been paying attention! In terms of their purpose, objectives, and the fact that the trips they are planning would be a one-way, the two organizations are very similar. But even more interesting is what these and other space organizations like them represent.

In an age when private space travel and exploration are beginning in earnest, crowdfunded, volunteer groups are emerging with the common goal of making things happen ahead of anyone else’s schedule. Whereas space was once the exclusive province of government-sanctioned and funded agencies, now the public is stepping in to assume a measure of control.

And thanks to new media and communications, the money, talent, and energy needed are all available. It’s just a matter of bringing them all together!

Source: news.cnet.com

A Kinder, Gentler Internet: California’s “Erase Button”

cyber bullyingIn the early nineties, the internet was greeted with immense optimism and anticipation. Scarcely a week went by without some major personality – Al Gore and Bill Gates come to mind – championing its development, saying it would bring the world together and lead to “the information age”. After just a few years, these predictions were being mocked by just about everyone on the planet who had access.

Rehtaeh_ParsonsYes, despite all that has been made possible by the internet, the heady optimism that was present in those early days seem horribly naive by today’s standards. In addition to making virtually any database accessible to anyone, the world wide web has also enabled child pornographers, hate speech, conspiracy theorists and misinformation like never before.

What’s more, a person’s online presence opens them to new means of identity theft, cyberbullying, and all kinds of trolling and harassment. Who can forget the cases of Amanda Todd or Rethaeh (Heather) Parsons? Two young women who committed suicide due to relentless and disgusting bullying that was able to take place because there simply was no way to stop it all.

amanda_toddsuicide.jpeg.size.xxlarge.letterboxAnd with the ever expanding online presence of children and youths on the internet, and little to no controls to monitor their behavior, there are many campaigns out there that hope to reign in the offenders and protect the users. But there are those who have gone a step further, seeking to put in place comprehensive safeguards so that trollish behavior and hurtful comments can be stopped before it becomes a permanent part of the digital stream.

One such person is California Governor Jerry Brown, who recently signed a bill into law that requires all websites to provide an online “erase button” for anyone under 18 years of age. The stated purpose of the law is to help protect teens from bullying, embarrassment and harm to job and college applications from online posts they later regret. The law, which is designated SB568, was officially passed on Sept. 23rd and will go into effect Jan 1st, 2015.

kid-laptop-156577609_610x406Common Sense Media, a San Francisco based non-profit organization that advocates child safety and family issues, was a major supporter of the bill. In a recent interview, CEO James Steyer explained the logic behind it and how it will benefit youths:

Kids and teens frequently self-reveal before they self-reflect. In today’s digital age, mistakes can stay with and haunt kids for their entire life. This bill is a big step forward for privacy rights, especially since California has more tech companies than any other state.

The law is not without merit, as a 2012 Kaplan survey conducted on college admissions counselors shows. In that study, nearly a quarter of the counselors interviewed said they checked applicants’ social profiles as part of the admission process. Of those counselors, 35% said what they found – i.e. vulgarities, alcohol consumption, “illegal activities” – negatively affected their applicants’ admissions chances.

smartphoneteensBut of course, the bill has its share of opponents as well. Of those who voted against it, concerns that the law will burden websites with developing policies for different states appeared to be paramount. Naturally, those who support the bill hope it will spread, thus creating a uniform law that will remove the need to monitor the internet on a state-by-state basis.

At present, major social media sites such as Facebook, Twitter, Instagram and Vine already allow users of any age to delete their posts, photos and comments. California’s “eraser button” law requires that all websites with users in the state follow this policy from now on. And given the presence of Silicon Valley and the fact that California has one of the highest per capita usages of the internet in the country, other states are sure to follow.

facebook-privacyThe new law also prohibits youth-oriented websites or those that know they have users who are minors from advertising products that are illegal to underage kids, such as guns, alcohol and tobacco. Little wonder then why it was also supported by organizations like Children NOW, Crime Victims United, the Child Abuse Prevention Center and the California Partnership to End Domestic Violence.

In addition to being a legal precedent, this new law represents a culmination of special interests and concerns that have been growing in size and intensity since the internet was first unveiled. And given the recent rise in parental concerns over cyberbullying and teen suicides connected to online harassment, its hardly surprising that something of this nature was passed.

Sources: news.cnet.com, cbc.ca, huffingtonpost.com

Ending HIV: Foot Cream Kills HIV Cells!

HIV-budding-ColorThe fight to end HIV has been long and ongoing. But in recent years, researchers have made some incredible breakthroughs in terms of treatment and vaccines. Well as it turns out, the fight may be getting a punch in the arm from a most unlikely source – an anti-fungal foot cream! Yes, not only does this common drug kill HIV, it is even more effective than some of today’s most cutting-edge drugs.

In a study performed at Rutgers New Jersey Medical School, the drug Ciclopirox was shown to completely eradicate infectious HIV when applied to cell cultures of the virus. But what was even more impressive was the fact that the virus didn’t bounce back when the drug was withheld. This means that, unlike most anti0viral drugs, it may not require a lifetime of use to keep HIV at bay.

ciclopiroxThe same group of researchers had previously shown that Ciclopirox – which was approved by the FDA and Europe’s EMA to treat foot fungus – inhibits the expression of HIV genes. Now they have found that it also blocks the essential function of the mitochondria, which results in the reactivation of the cell’s suicide pathway, all while sparing surrounding healthy cells.

This is key since one of the worst aspects of HIV – one that makes it particularly persistent, even in the face of strong antiviral treatments – is its ability to disable a cell’s altruistic suicide pathway. This “self-destruct protocol” is typically activated when a cell is damaged or infected. With the introduction of Ciclopirox, these cells are tricked into pulling a double negative, disabling the disabling of the suicide pathway.

HIVNaturally, the cream will have to be tested on humans before its efficacy as a topical HIV treatment can be tested. However, the fact that it’s already been deemed safe for one type of human use could make the regulatory process faster than usual. In fact, the researchers have noted that another FDA-approved drug now thought to help subdue HIV (called Deferiprone) skipped animal studies and went straight to human trials in South Africa.

Naturally, the Rutgers team hopes they too can go directly from their culture studies to human trials, and that the case involving Deferiprone will pave the way for a more streamlined testing process. This is likely, seeing as how there have been many breakthroughs in recent months and everyone – from researchers to patients to medical authorities – want to make treatments available as soon as possible.

Source: news.cnet.com

News From Space: Big Bang Vs. Black Hole

big bang_blackholeFor decades, the Big Bang Theory has remained the accepted theory of how the universe came to be, beating out challengers like the Steady State Theory. However, many unresolved issues remain with this theory, the most notable of which is the question of what could have existed prior to the big bang. Because of this, scientists have been looking for way to refine the theory.

Luckily, a group of theoretical physicists from the Perimeter Institute (PI) for Theoretical Physics in Waterloo, Ontario have announced a new interpretation on how the universe came to be. Essentially, they postulate that the birth of the universe could have happened after a four-dimensional star collapsed into a black hole and began ejecting debris.

big_bangThis represents a big revision of the current theory, which is that universe grew from an infinitely dense point or singularity. But as to what was there before that remain unknown, and is one of a few limitations of the Big Bang. In addition, it’s hard to predict why it would have produced a universe that has an almost uniform temperature, because the age of our universe (about 13.8 billion years) does not give enough time to reach a temperature equilibrium.

Most cosmologists say the universe must have been expanding faster than the speed of light for this to happen. But according to Niayesh Afshordi, an astrophysicist with PI who co-authored the study, even that theory has problems:

For all physicists know, dragons could have come flying out of the singularity. The Big Bang was so chaotic, it’s not clear there would have been even a small homogenous patch for inflation to start working on.

black_holeThe model Afshordi and her colleagues are proposing is basically a three-dimensional universe floating as a membrane (or brane) in a “bulk universe” that has four dimensions. If this “bulk universe” has four-dimensional stars, these stars could go through the same life cycles as the three-dimensional ones we are familiar with. The most massive ones would explode as supernovae, shed their skin and have the innermost parts collapse as a black hole.

The 4-D black hole would then have an “event horizon”, the boundary between the inside and the outside of a black hole. In a 3-D universe, an event horizon appears as a two-dimensional surface; but in a 4-D universe, the event horizon would be a 3-D object called a hypersphere. And when this 4-D star blows apart, the leftover material would create a 3-D brane surrounding a 3-D event horizon, and then expand.

planck-attnotated-580x372To simplify it a little, they are postulating that the expansion of the universe was triggered by the motion of the universe through a higher-dimensional reality. While it may sound complicated, the theory does explain how the universe continues to expand and is indeed accelerating. Whereas previous theories have credited a mysterious invisible force known as “dark energy” with this, this new theory claims it is the result of the 3-D brane’s growth.

However, there is one limitation to this theory which has to do with the nearly uniform temperature of the universe. While the model does explain how this could be, the ESA’s Planck telesceop recently mapped out the universe and discovered small temperature variations in the cosmic microwave background (CBM). These patches were believed to be leftovers of the universe’s beginnings, which were a further indication that the Big Bang model holds true.

big_bang1The PI team’s own CBM readings differ from this highly accurate survey by about four percent, so now they too are going back to the table and looking to refine their theory. How ironic! However, the IP team still feel the model has worth. While the Planck observations show that inflation is happening, they do not show why the inflation is happening.

Needless to say, we are nowhere near to resolving how the universe came to be, at least not in a way that resolves all the theoretical issues. But that’s the things about the Big Bang – it’s the scientific equivalent of a Hydra. No matter how many times people attempt to discredit it, it always comes back to reassert its dominance!

Source: universetoday.com, perimeterinstitute.ca