The Future is Here: Memory Prosthetics

Restoring Active Memory (Shutterstock)Developing implants that can restore damaged neural tissue – either by restoring the connections between damaged memory synapses or restoring cognitive function – is seen as the next great leap in prosthetic medicine. In recent years, steps have been taken in both areas, offering patients and willing subjects the option of restoring or hacking their neurology.

For example, last year, researchers working at the University of California and the University of Pennsylvania successfully managed to design and implement a brain implant that acted as a bypass for damaged brain tissue. This neural prosthesis successfully restored brain function in rats, demonstrating that the closed-loop brain-machine-brain interface could one day perform the same function in brain-damaged humans.

brain-darpa-617x416And as with many such projects, the Defense Advanced Research Projects Agency (DARPA) soon became involved, taking up the reins to fund the research and development of the technology. As part of the DARPA Restoring Active Memory (RAM) program, the device is currently being developed with the hope of restoring memory function in veterans who have suffered a traumatic brain injury.

Currently, over 270,000 military service members since 2000 and an estimated 1.7 million civilians in the US are affected by TBI, which often manifests as an inability to retrieve memories formed before being injured and an impaired ability to form new memories. Currently, there are also no effective treatments available, and beyond veterans, there are countless people around the world who suffer from the same condition as a result of accidents.

brainscansThe teams will first develop computer models that describe how neurons code memories, as well as analyzing neural signals in order to understand how targeted stimulation might help restore the brain’s ability to form memories. The UCLA team will use data collected from epilepsy patients that already have electrodes implanted in their brains to develop a model of the hippocampal-entorhinal system – known to be involved in learning and memory.

Meanwhile, the University of Pennsylvania team will study neurosurgical patients with implanted brain electrodes, recording data as they play computer-based memory games in order to gain an understanding of how successful memory function works. All patients will be volunteers, and the teams then plan to integrate these models into implantable closed-loop systems.

brain_chip2Like the research on rats, the implant will pick up neural signals from an undamaged section of the brain and route it around the damaged portion, effectively forming a new neural link that functions as well as the undamaged brain. And this is not the only research that aims to help assist in memory function when it comes to veterans and those suffering from TBI.

At Lawrence Livermore National Labs (LLNL), for example, efforts are being made to create a new type of “memory bridge”. This research builds upon similar efforts from USC, where researcher Ted Berger developed the first implantable memory device (coincidentally, also as part of DARPA’s RAM program) where limited electrodes were applied to the hippocampal regions of the brain to assist in recall and memory formation.

brain-implant-hippocampus-usc-640x424However, until now, no research lab has had any real clue as to what kinds of “codes” are involved when applying electrical stimulus to the brain. The LLNL group, which previously contributed to the groundbreaking Argus II retinal prosthesis is now taking a more integrated approach. With the recent announcement of ample federal BRAIN Initiative funding, they aim to build multifunction electro-optical-chemical neural sensor-effectors.

On the electrical end, LLNL’s new wafer technology will use fairly high electrode counts (perhaps 500-1000 spots). Compared to the usual higher density 11,000-electrode chips that have been used in the past, these chips will have more sparsely distributed electrode locations. Integrated light guides will provide conduits for optogenetic manipulations, and as an added bonus bi-directional fluid channels for any number of chemical exchanges are also etched in. 

llnl-brain-implantAnd like their California/Penn colleagues, the LLNL has teamed up with DARPA to get the funding they need to make this project a reality. So far, DARPA funders have brought in the implant heavyweight Medtronic, which made news last year with the development of its own closed-loop stimulators, to lend its expertise. In their case, the stimulators merged Brain-Computer Interface (BCI) with Deep Brain Stimulation (DBS) to treat Parkinson’s.

Unfortunately, while immense progress in being made at the hardware end of things, there is still the matter of cracking the brains code first. In other words, where the device needs to be placed and which neurons need to be precisely controlled remain a mystery. Not all neurons are the same, and control hierarchies and preferred activation paths will inevitably emerge.

DeepBrain-New1Ultimately, what is needed in order to make precisely-targeted deep brain stimulation (DBS) possible is a real 3D model of the regions of the brain involved. Multiple efforts are underway, not the least of which are the work of Michele Tagliati’s group from the Movement Disorders Program in the department of neurology at Cedars-Sinai, or the Human Brain Project in Luasanne, Switzerland.

In these and other cases, the use of MRIs and brain scans to create a working map of the human brain – so that attempts to create biomimetic prosthetics that can enhance or assist in it’s functions – is the ultimate goal. And once researchers have a better idea of what the brain’s layout is, and what kinds of control hierarchies and paths are involved, we can expect to see brain implants becoming a regular feature of medicine.

And as always, devices that can restore function also open the way for the possibility of enhancement. So we can also expect that bionics prosthetics that restore memory and cognitive function will give way to ones that boost these as well. The dream of Homo Superior, the post-human, or transhumanism – whatever you choose to call it – is looking to be increasingly within our grasp.

And be sure to check out this video from LLNL showcasing how their new neural implant works:


Sources:
 cnet.com, extremetech.com, darpa.mil

News from Space: First Couple to go to Mars!

marsJane Poynter and Taber MacCallum are a pretty interesting couple. Like most, they plan trips together to new and exciting destinations. But unlike most, they plan to go to Mars, and they just might see their dream come true. Twenty years ago, they founded the private space company Paragon Space Development Corporation, with the aim of finding the most feasible way to send two people on a round-trip flyby of the Red Planet.

And now, after many years of planning, they may finally get to see it come to fruition. The only problem is, the window for this launch – in 2021 when planet Earth and Mars will be in alignment – is fast approaching. And a number of technical and logistical issues (i.e. how to shield themselves against deadly radiation, how to store their waste, how much food, water, and air to bring) still need to be resolved.

Inspiration_Mars (2)The mission – called Inspiration Mars and spearheaded by millionaire space tourist Dennis Tito – is the most ambitious of Paragon’s many projects. The company is also one of the country’s leading designers of life support systems and body suits for extreme environments, and they are currently developing a vehicle for commercial balloon trips to the stratosphere and technology for private moon landings.

But they have the most grandiose hopes for Mars. They believe that sending the first humans into the orbit of another planet could ignite a 21st century “Apollo moment” that will propel American students back into the sciences and inspire young innovators. Beyond that, and in advance of NASA’s proposed 2030 manned mission to Mars, it might just inspire a full-scale colonization effort.

Photograph by John de DiosThe couple’s drive to explore space was born in a giant glass dome near Tuscon, Arizona called Biosphere 2 in the early 90s. For two years (between 1991 and 1993), eight people – including Poynter and MacCallum – lived inside this dome as part of a prototype space colony. The eccentric, privately funded science experiment contained miniature biomes that mimicked Earth’s environments.

This included a jungle, desert, marshland, savannah and an ocean all crammed into an area no larger than two and a half football fields. The crew subsisted on a quarter-acre agricultural plot and went about their lives while medical doctors and ecologists observed from outside. All went relatively smoothly until, 16 months into the experiment, crew members began suffering from severe fatigue and sleep apnea.

Mars_OneThey discovered that the dome’s oxygen content had substantially dropped and, when one member fell into a state of confusion in which he could not add simple numbers, decided to refill the dome with oxygen, breaking the simulation of space-colony self-sufficiency. The project was deemed a failure by many, with Time Magazine going as far as to name it one of the 100 worst ideas of the century.

But the crew persisted for their full two-year trial and, if nothing else, emerged intimately aware of the mental traumas of prolonged isolation—crucial wisdom for anyone seriously considering traveling to another planet. As Poynter described it, the challenges were numerous and varied:

Some of the easier ones to get your head around are things like depression and mood swings—that’s kind of obvious. Weird things are things like food stealing and hoarding.

Mars_simulationThe more severe symptoms were similar to the delusions reported by early 20th century explorers who hallucinated while trekking for months through the featureless white expanse of Antarctica. She describes one instance in which she was standing in the sweet potato field about to harvest greens to feed the Biosphere 2 goats when she suddenly felt as if she had stepped through a time machine:

I came out the other side and was embroiled in a very fervent argument with my much older brother. And what was so disconcerting about it was that it really was hallucinatory. It was like I could smell it, feel it. It was very weird.

Six months into Biosphere 2, the couple began to think about life after the experiment and channeled their waning energy into a business plan. They wanted to build on the skills and ecological knowledge they were accruing during the experiment, while also playing off Biosphere 2’s space-oriented goals, and finally landed on building life support systems for an eventual trip to Mars.

Earth_&_Mir_(STS-71)MacCallum blogged about these plans while still living inside the dome, and managed to sign up Lockheed Martin aerospace engineer Grant Anderson as a co-founder, and signed legal papers with Poynter to incorporate Paragon. After Biosphere 2 project, both began working with a group from NASA to test an ecological experiment on the Russian Space Station MIR.

Then in December 2012, Paragon teamed up with another commercial space flight company named Golden Spike to build a space suit, thermal control, and life support technologies for commercial trips to the Moon aimed to launch in 2020. In December 2013, they named former astronaut and personal friend Mark Kelly as the director of flight crew operations on World View, an effort to bring tourists on a balloon ride to the middle of the stratosphere by 2016.

near-space_balloon5In short, Poynter and MacCallum have their fingers in just about every commercial space venture currently on the table outside of SpaceX and Virgin Galactic, of course. Over the past two decades, their company has grown to employ about 70 engineers and scientists and is still growing today. Their focus is on creative teamwork, hoping to foster the kind of innovative spirit needed to make space missions possible.

Still, despite Paragon’s best efforts and accomplishments, many do not believe their ambitions to send a human couple to Mars by the 2020s will pan out. Former NASA astronaut Thomas Jones is one such person, who said in an interview with WIRED that he thinks that humans won’t reach Mars orbit until the 2030s, and will struggle to do so without the financial and infrastructural support of NASA.

mars-mission1Originally, Dennis Tito hoped to finance the project entirely independently, using crowd-sourced funds and philanthropy. The original goal was also to get the project off the ground by 2017, when Earth and Mars would align in such a way that a rocket could slingshot to and from Mars in just 501 days. But with further analysis, Tito and Paragon realized they did not have the resources or money to pull off the mission by 2017.

They identified another planetary alignment in 2021 that would allow for a slightly-longer 580-day trip, but they still doubt they can achieve this without a bit of government support. According to McCallum:

There was really no way that we could find to practically use existing commercial rockets. We were hoping we could pull together a mission using existing hardware, but you just don’t get to go to Mars that easy.

During recent hearings with NASA, Tito explained that he would need roughly $1 billion over the next four or five years to develop the space launch system and other aspects of the mission. NASA was not readily willing to agree to this and they put the issue on hold. But regardless of whether Inspiration Mars is successful in 2021, Jones believes these commercial space efforts will help stir momentum and public interest in space.

oriontestflightAll of this would be great for NASA, which is beholden to public opinion and still looking to Congress to allocate the money needed to new infrastructure and fund future missions. Ergo, Paragon’s involvement in an array of different space endeavors that embed space in the American consciousness could improve their chances of getting Inspiration Mars off the ground. Or as he put it:

I think it is going to lead to an explosion of ideas of how we can use space to make a buck, and that’s all to the good. And so if these companies can develop a track record of success, and people have greater confidence that they can personally experience space, then it may become more relevant to our society and country, and then the U.S. may have a broader base of support for funding for NASA.

At the end of last year, the team successfully completed the major components of the life support system for Inspiration Mars and did a full test of all the major systems together in the lab. They recycled urine, made oxygen, and removed carbon dioxide from the system – all the things they would need to do to keep a crew alive for an Inspiration Mars mission.

Poynter_MacCallum_Portrait-330And MacCallum believes a trip to Mars that would use these life support systems could inspire the next great generation of innovators, much as the Apollo missions inspired the current generation of innovators and astronauts. McCallum turned five on July 20th, 1969 – the day that Apollo 11 landed on the Moon, and credits that historic event for inspiring him to take an interest in space and enter the Biosphere 2 project.

And though they hadn’t originally intended to be the couple that would take part in the Inspiration Mars mission, they have indicated that they would be willing to throw their hats into the ring. After all, they meet the basic requirements for the mission, being a physically fit middle-aged couple, and the Biosphere 2 project lent them some experience living in isolation.

Mars_Earth_Comparison-580x356But most important to the couple is the idea of being able to call back to students on Earth and describe the experience. As he described it, watching footage of the Pale Blue Dot drift away and the Red Planet’s drift closer would be the most amazing thing ever for a child to behold:

That would have completely blown my mind as a middle schooler. And we would have 500 days to have these conversations with students all around the world.

Of that, I have little doubt. And even if Inspiration Mars does not get off the ground (metaphorically or literally), it has hardly the only private space venture currently in the works. For example, Elon Musk and his commercial space firm SpaceX has made incredibly progress with the development of the reusable-rocket system. And Mars One, another crowdfunded venture, is still in the works and aiming to send volunteers on a one-way trip by 2024.

No telling how and when the first human beings will walk on the Red Planet. But at this juncture, it seems like a foregone conclusion that not only will it be happening, but within our lifetimes. And while we’re waiting, be sure to check out the Inspiration Mars video below. I can attest to it being quite… inspiring 😉


Source:
wired.com
, paragonsdc.com, inspirationmars.org

Happy 147th Birthday Canada!

happy_canada_dayHello all, and happy Canada Day to you! Today is the national holiday that marks the day that Confederation took place. For those not familiar, this historic event took place on July 1, 1867, when the three colonies of British North America came together to become the four provinces – Ontario, Quebec, Nova Scotia and New Brunswick – of the Dominion of Canada. Thereafter, July 1st became known as “Dominion Day” – until 1982 when the Canadian constitution was patriated, at which point it was renamed Canada Day.

Growing up in Ottawa – the nation’s capitol – Canada Day was always a special time. As a kid, it usually involved having a barbeque at home and proceeding to head downtown to see the crowds gather on Parliament Hill. At sundown, the fireworks display would begin, and we’d watch as from Major’s Hill Park (just across the canal from Parliament Hill) as thousands of them would go off above the clock tower (pictured above).

As I got older, the ritual remained the same, only it began to involve myself and my closest friends doing it instead. We’d start out at a friend’s house (more often than not, Luke would be the host). After some burgers or some other barbequed meal, washed down generously with beer or some other spirituous beverage, we’d proceed downtown. Once there, we’d get lost in the festivities, which would be pretty damn raucous and overwhelming!

jul-1st-canada-day-cityTo describe it, imagine 100,000 people crowded into the space of about 3 square kms. That’s where Parliament Hill, the downtown area, the Rideau Center, the old Bytown area, the War Memorial, the entrance to the Rideau Canal, and a slew of other major attractions are located. Vendors and buskers are out and about, people have their faces painted and sport flags, and the festive spirit just gets inside you and makes you want to party.

And of course, there is the televised concert taking place on the Hill, which features bands from all over Canada leading people in celebration. It was one of my fondest memories of living in Ottawa, and something I truly miss now that I live out here on the West Coast. Of course, Victoria puts on a might fine celebration as well, which has all the same high points. But since this is not the town I grew up in, it’s never quite had the same meaning for me.

So here’s to Canada, and here’s hoping that everybody out there has a day that holds special meaning to them too, and that they get to enjoy it this year without incident, stress or worry. And to all my American compatriots (including my sister and brother-in-law) happy soon-to-be Fourth of July!

Curiosity Rover’s First Martian Anniversary

Happy (Martian) Birthday Curiosity!

J. C. Conway's avatarJ. C. Conway

A Martian year is 687 Earth days long. Accordingly, NASA’s Curiosity Rover reaches its one-year Martian Anniversary on June 24, 2014 (Earth Calendar), 687 days after its mission began.

Curiosity has already accomplished the mission’s main goal of determining whether Mars once offered environmental conditions favorable for microbial life. One of Curiosity’s first major findings after landing on the Red Planet in August 2012 was an ancient riverbed at its landing site. Nearby, at an area known as Yellowknife Bay, the mission met its main goal of determining whether the Martian Gale Crater ever was habitable for simple life forms. The answer, a historic “yes,” came from two mudstone slabs that the rover sampled with its drill. Analysis of these samples revealed the site was once a lakebed with mild water, the essential elemental ingredients for life, and a type of chemical energy source used by some microbes on Earth. If…

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Complications of the EPA’s Clean Power Plan

The latest effort to fight Climate Change from the US government, and how it may fall short…

Planet Earth Weekly's avatarPlanet Earth Weekly

Will the EPA do enough to make a difference? Five states have the top polluting coal plants int the U.S.

Are complicated politics going to fix our planet’s changing climate or is it time for each individual American to take responsibility for the growing problem?

By Linn Smith

June 18, 2014—-An article in the USA TODAY, June 9, 2014, titled, Retiring Coal Plants Won’t Do Much to Clean Air, caught my attention while sitting in the local cafe in a small town in the mid-west. Why? Because the proposed plants to be closed account for only 4% of all the CO2 emissions in the U.S. and “are mostly small, old generating units in the Midwest and South.” According to USA TODAY, the top polluting coal plants are located predominantly in five states. Texas has the most with 19, followed by Pennsylvania, West Virginia, Alabama and Georgia and the top 10% of these coal plants account for 69% of the…

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The Nibble Approach to Asteroid Testing

Update on plans for possible asteroid mining!

J. C. Conway's avatarJ. C. Conway

NASA released this animation of a mission to capture a boulder from the surface of an asteroid. A NASA spacecraft, called an asteroid redirect vehicle, would use robotic arms to pluck a 3-meter boulder off the asteroid. The spacecraft would then enter a stable lunar orbit with the boulder where astronauts could then visit it and take samples. Take a look: 

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