The Future is Here: Memory Prosthetics

Restoring Active Memory (Shutterstock)Developing implants that can restore damaged neural tissue – either by restoring the connections between damaged memory synapses or restoring cognitive function – is seen as the next great leap in prosthetic medicine. In recent years, steps have been taken in both areas, offering patients and willing subjects the option of restoring or hacking their neurology.

For example, last year, researchers working at the University of California and the University of Pennsylvania successfully managed to design and implement a brain implant that acted as a bypass for damaged brain tissue. This neural prosthesis successfully restored brain function in rats, demonstrating that the closed-loop brain-machine-brain interface could one day perform the same function in brain-damaged humans.

brain-darpa-617x416And as with many such projects, the Defense Advanced Research Projects Agency (DARPA) soon became involved, taking up the reins to fund the research and development of the technology. As part of the DARPA Restoring Active Memory (RAM) program, the device is currently being developed with the hope of restoring memory function in veterans who have suffered a traumatic brain injury.

Currently, over 270,000 military service members since 2000 and an estimated 1.7 million civilians in the US are affected by TBI, which often manifests as an inability to retrieve memories formed before being injured and an impaired ability to form new memories. Currently, there are also no effective treatments available, and beyond veterans, there are countless people around the world who suffer from the same condition as a result of accidents.

brainscansThe teams will first develop computer models that describe how neurons code memories, as well as analyzing neural signals in order to understand how targeted stimulation might help restore the brain’s ability to form memories. The UCLA team will use data collected from epilepsy patients that already have electrodes implanted in their brains to develop a model of the hippocampal-entorhinal system – known to be involved in learning and memory.

Meanwhile, the University of Pennsylvania team will study neurosurgical patients with implanted brain electrodes, recording data as they play computer-based memory games in order to gain an understanding of how successful memory function works. All patients will be volunteers, and the teams then plan to integrate these models into implantable closed-loop systems.

brain_chip2Like the research on rats, the implant will pick up neural signals from an undamaged section of the brain and route it around the damaged portion, effectively forming a new neural link that functions as well as the undamaged brain. And this is not the only research that aims to help assist in memory function when it comes to veterans and those suffering from TBI.

At Lawrence Livermore National Labs (LLNL), for example, efforts are being made to create a new type of “memory bridge”. This research builds upon similar efforts from USC, where researcher Ted Berger developed the first implantable memory device (coincidentally, also as part of DARPA’s RAM program) where limited electrodes were applied to the hippocampal regions of the brain to assist in recall and memory formation.

brain-implant-hippocampus-usc-640x424However, until now, no research lab has had any real clue as to what kinds of “codes” are involved when applying electrical stimulus to the brain. The LLNL group, which previously contributed to the groundbreaking Argus II retinal prosthesis is now taking a more integrated approach. With the recent announcement of ample federal BRAIN Initiative funding, they aim to build multifunction electro-optical-chemical neural sensor-effectors.

On the electrical end, LLNL’s new wafer technology will use fairly high electrode counts (perhaps 500-1000 spots). Compared to the usual higher density 11,000-electrode chips that have been used in the past, these chips will have more sparsely distributed electrode locations. Integrated light guides will provide conduits for optogenetic manipulations, and as an added bonus bi-directional fluid channels for any number of chemical exchanges are also etched in. 

llnl-brain-implantAnd like their California/Penn colleagues, the LLNL has teamed up with DARPA to get the funding they need to make this project a reality. So far, DARPA funders have brought in the implant heavyweight Medtronic, which made news last year with the development of its own closed-loop stimulators, to lend its expertise. In their case, the stimulators merged Brain-Computer Interface (BCI) with Deep Brain Stimulation (DBS) to treat Parkinson’s.

Unfortunately, while immense progress in being made at the hardware end of things, there is still the matter of cracking the brains code first. In other words, where the device needs to be placed and which neurons need to be precisely controlled remain a mystery. Not all neurons are the same, and control hierarchies and preferred activation paths will inevitably emerge.

DeepBrain-New1Ultimately, what is needed in order to make precisely-targeted deep brain stimulation (DBS) possible is a real 3D model of the regions of the brain involved. Multiple efforts are underway, not the least of which are the work of Michele Tagliati’s group from the Movement Disorders Program in the department of neurology at Cedars-Sinai, or the Human Brain Project in Luasanne, Switzerland.

In these and other cases, the use of MRIs and brain scans to create a working map of the human brain – so that attempts to create biomimetic prosthetics that can enhance or assist in it’s functions – is the ultimate goal. And once researchers have a better idea of what the brain’s layout is, and what kinds of control hierarchies and paths are involved, we can expect to see brain implants becoming a regular feature of medicine.

And as always, devices that can restore function also open the way for the possibility of enhancement. So we can also expect that bionics prosthetics that restore memory and cognitive function will give way to ones that boost these as well. The dream of Homo Superior, the post-human, or transhumanism – whatever you choose to call it – is looking to be increasingly within our grasp.

And be sure to check out this video from LLNL showcasing how their new neural implant works:


Sources:
 cnet.com, extremetech.com, darpa.mil

The Future is Here: Overcoming Paralysis

neurobridge_ianIan Burkhart, a 23-year-old quadriplegic from Dublin, Ohio, was injured in 2010 in a diving accident, breaking his neck on a sandbar and paralyzing his body from the neck down. He was left with some use of his arms, but lost the use of his legs, hands, and fingers. Thanks to a new device known as the Neurobridge though – a device that allows the brains signals to bypass the severed spinal cord – Burkhart has now moved his right hand and fingers for the first time since the accident.

This device, which was developed in concert by the Ohio State University Wexner Medical Center and the non-profit company Battelle, consists of a pea-sized chip that contains an an array of 96 electrodes, allows researchers to look at detailed signals and neural activity emanating from the patient’s brain. This chip was implanted in Ian’s brain two months ago, when neurosurgeon Dr Ali Rezai of Ohio State University performed the surgery that would implant the sensor chip into the motor cortex of his brain.

neuromorphic_revolutionBattelle has been working on neurosensing technology for almost a decade. As Chad Bouton, the leader of the Neurobridge project at Battelle, explains:

We were having such success in decoding brain activity, we thought, ‘Let’s see if we could remap the signals, go around something like a spinal cord injury and then translate the signals into something that the muscles could understand and help someone paralyzed regain control of their limb’.

During the test, which occurred in June, the implanted chip read and interpreted the electrical activity in Burkhart’s brain and sent it to a computer. The computer then recoded the signal, and sent it to a high-definition electrode stimulation sleeve Burkhart wore on his right arm, a process that took less than a tenth of a second and allowed Burkhart to move his paralysed fingers. Basically, Burkhart is able to move his hand by simply thinking about moving his hand, and the machine does the rest.

neurobridge1A team led by Chad Bouton at Battelle spent nearly a decade developing the algorithms, software and sleeve. Then, just two years ago, Dr Ali Rezai and Dr Jerry Mysiw were brought on board to design the clinical trials. Burkhart became involved with the study after his doctor mentioned it to him and he learned he was an ideal candidate. He had the exact level of injury the researchers were looking for, is young and otherwise healthy, and lives close to the Ohio State University Wexner Medical Center, where the research is being conducted.

Even so, Burkhart had to think hard before agreeing to the surgery. He also knew that the surgery wouldn’t magically give him movement again. He would have to undergo rigorous training to regain even basic hand function. Mainly, his experience would help move along future technological advances. However, he was excited to be taking part in cutting-edge research which would ultimately help people like him who have suffered from spinal injuries and paralysis.

enhancementPost-surgery, Burkhart still had a lot of thinking to do, this time, in order to move his hand. As he explained:

It’s definitely great for me to be as young as I am when I was injured because the advancements in science and technology are growing rapidly and they’re only going to continue to increase… Mainly, it was just the fact that I would have to have brain surgery for something that wasn’t needed… Anyone able bodied doesn’t think about moving their hand, it just happens. I had to do lots of training and coaching.

The hand can make innumerable complex movements with the wrist, the fingers, and the fist. In order for Battelle’s software to read Ian’s mind, it has to look for subtle changes in the signals coming from Ian’s brain. As Bouton explains it, the process is like walking into a crowded room with hundreds of people trying to talk to each other, and you’re trying to isolate one particular conversation in a language that you don’t understand.

neurobridgeAt this point, Burkhart can perform a handful of movement patterns, including moving his hand up and down, opening and closing it, rotating it, and drumming on a table with his fingers. All of this can only be done while he’s in the hospital, hooked up to the researchers’ equipment. But the ultimate goal is to create a device and a software package that he can take with him, giving him the ability to bypass his injury and have full ambulatory ability during everyday activities.

This isn’t the only research looking into bringing movement back to the paralyzed. In the past, paralyzed patients have been given brain-computer interfaces, but they have only been able to control artificial limbs – i.e. Zak Water’s mind-controlled leg or the BrainGate’s device that allow stroke victims to eat and drink using a mind-controlled robotic arm. Participants in an epidural stimulator implant study have also been able to regain some movement in their limbs, but this technology works best on patients with incomplete spinal cord injuries.

braingate_drinkassistBurkhart is confident that he can regain even more movement back from his hand, and the researchers are approved to try the technology out on four more patients. Ultimately, the system will only be workable commercially with a wireless neural implant, or an EEG headset – like the Emotiv, Insight or Neurosky headsets. The technology is also being considered for stroke rehabilitation as well, another area where EEG and mind-control technology are being considered as a mean to recovery.

From restoring ambulatory ability through mind-controlled limbs and neurosensing devices to rehabilitating stroke victims with mind-reading software, the future is fast shaping up to be a place where no injuries are permanent and physical disabilities and neurological impairments are a thing of the past. I think I can safely speak for everyone when I say that watching these technologies emerge makes it an exciting time to be alive!

And be sure to check out this video from the OSUW Medical Center that shows Ian Burkhart and the Batelle team testing the Neurobridge:


Sources: cnet.com, fastcoexist.com

Judgement Day Update: Super-Strong Robotic Muscle

robot-arm-wrestling-03-20-09In their quest to build better, smarter and faster machines, researchers are looking to human biology for inspiration. As has been clear for some time, anthropomorphic robot designs cannot be expected to do the work of a person or replace human rescue workers if they are composed of gears, pullies, and hydraulics. Not only would they be too slow, but they would be prone to breakage.

Because of this, researchers have been working looking to create artificial muscles, synthetics tissues that respond to electrical stimuli, are flexible, and able to carry several times their own weight – just like the real thing. Such muscles will not only give robots the ability to move and perform tasks with the same ambulatory range as a human, they are likely to be far stronger than the flesh and blood variety.

micro_robot_muscleAnd of late, there have been two key developments on this front which may make this vision come true. The first comes from the US Department of Energy ’s Lawrence Berkeley National Laboratory, where a team of researchers have demonstrated a new type of robotic muscle that is 1,000 times more powerful than that of a human’s, and has the ability to catapult an item 50 times its own weight.

The artificial muscle was constructed using vanadium dioxide, a material known for its ability to rapidly change size and shape. Combined with chromium and fashioned with a silicone substrate, the team formed a V-shaped ribbon which formed a coil when released from the substrate. The coil when heated turned into a micro-catapult with the ability to hurl objects – in this case, a proximity sensor.

micro_robot_muscle2pngVanadium dioxide boasts several useful qualities for creating miniaturized artificial muscles and motors. An insulator at low temperatures, it abruptly becomes a conductor at 67° Celsius (152.6° F), a quality which makes it an energy efficient option for electronic devices. In addition, the vanadium dioxide crystals undergo a change in their physical form when warmed, contracting along one dimension while expanding along the other two.

Junqiao Wu, the team’s project leader, had this to say about their invention in a press statement:

Using a simple design and inorganic materials, we achieve superior performance in power density and speed over the motors and actuators now used in integrated micro-systems… With its combination of power and multi-functionality, our micro-muscle shows great potential for applications that require a high level of functionality integration in a small space.

In short, the concept is a big improvement over existing gears and motors that are currently employed in electronic systems. However, since it is on the scale of nanometers, it’s not exactly Terminator-compliant. However, it does provide some very interesting possibilities for machines of the future, especially where the functionality of micro-systems are concerned.

graphene_flexibleAnother development with the potential to create robotic muscles comes from Duke University, where a team of engineers have found a possible way to turn graphene into a stretchable, retractable material. For years now, the miracle properties of graphene have made it an attractive option for batteries, circuits, capacitors, and transistors.

However, graphene’s tendency to stick together once crumpled has had a somewhat limiting effect on its applications. But by attacking the material to a stretchy polymer film, the Duke researchers were able to crumple and then unfold the material, resulting in a properties that lend it to a broader range of applications- including artificial muscles.

robot_muscle1Before adhering the graphene to the rubber film, the researchers first pre-stretched the film to multiple times its original size. The graphene was then attached and, as the rubber film relaxed, the graphene layer compressed and crumpled, forming a pattern where tiny sections were detached. It was this pattern that allowed the graphene to “unfold” when the rubber layer was stretched out again.

The researchers say that by crumpling and stretching, it is possible to tune the graphene from being opaque to transparent, and different polymer films can result in different properties. These include a “soft” material that acts like an artificial muscle. When electricity is applied, the material expands, and when the electricity is cut off, it contracts; the degree of which depends on the amount of voltage used.

robot_muscle2Xuanhe Zhao, an Assistant Professor at the Pratt School of Engineering, explained the implications of this discovery:

New artificial muscles are enabling diverse technologies ranging from robotics and drug delivery to energy harvesting and storage. In particular, they promise to greatly improve the quality of life for millions of disabled people by providing affordable devices such as lightweight prostheses and full-page Braille displays.

Currently, artificial muscles in robots are mostly of the pneumatic variety, relying on pressurized air to function. However, few robots use them because they can’t be controlled as precisely as electric motors. It’s possible then, that future robots may use this new rubberized graphene and other carbon-based alternatives as a kind of muscle tissue that would more closely replicate their biological counterparts.

artificial-muscle-1This would not only would this be a boon for robotics, but (as Zhao notes) for amputees and prosthetics as well. Already, bionic devices are restoring ability and even sensation to accident victims, veterans and people who suffer from physical disabilities. By incorporating carbon-based, piezoelectric muscles, these prosthetics could function just like the real thing, but with greater strength and carrying capacity.

And of course, there is the potential for cybernetic enhancement, at least in the long-term. As soon as such technology becomes commercially available, even affordable, people will have the option of swapping out their regular flesh and blood muscles for something a little more “sophisticated” and high-performance. So in addition to killer robots, we might want to keep an eye out for deranged cyborg people!

And be sure to check out this video from the Berkley Lab showing the vanadium dioxide muscle in action:


Source:
gizmag.com, (2)
, extremetech.com, pratt.duke.edu

Biggest Scientific Breakthroughs of 2013

center_universe2The new year is literally right around the corner, folks. And I thought what better way to celebrate 2013 than by acknowledging its many scientific breakthroughs. And there were so many to be had – ranging in fields from bioresearch and medicine, space and extra-terrestrial exploration, computing and robotics, and biology and anthropology – that I couldn’t possibly do them all justice.

Luckily, I have found a lovely, condensed list which managed to capture what are arguably the biggest hits of the year. Many of these were ones I managed to write about as they were happening, and many were not. But that’s what’s good about retrospectives, they make us take account of things we missed and what we might like to catch up on. And of course, I threw in a few stories that weren’t included, but which I felt belonged.

So without further ado, here are the top 12 biggest breakthroughs of 2013:

1. Voyager 1 Leaves the Solar System:

For 36 years, NASA’s Voyager 1 spacecraft has travelling father and farther away from Earth, often at speeds approaching 18 km (11 miles) per second. At a pace like that, scientists knew Voyager would sooner or later breach the fringe of the heliosphere that surrounds and defines our solar neighborhood and enter the bosom of our Milky Way Galaxy. But when it would finally break that threshold was a question no one could answer. And after months of uncertainty, NASA finally announced in September that the space probe had done it. As Don Gurnett, lead author of the paper announcing Voyager’s departure put it: “Voyager 1 is the first human-made object to make it into interstellar space… we’re actually out there.”

voyager12. The Milky Way is Filled with Habitable Exoplanets:

After years of planet hunting, scientists were able to determine from all the data gathered by the Kepler space probe that there could be as many as 2 billion potentially habitable exoplanets in our galaxy. This is the equivalent of roughly 22% of the Milky Way Galaxy, with the nearest being just 12 light years away (Tau Ceti). The astronomers’ results, which were published in October of 2013, showed that roughly one in five sunlike stars harbor Earth-size planets orbiting in their habitable zones, much higher than previously thought.

exoplanets23. First Brain to Brain Interface:

In February of 2013, scientists announced that they had successfully established an electronic link between the brains of two rats. Even when the animals were separated by thousands of kms distance, signals from the mind of one could help the second solve basic puzzles in real time. By July, a connection was made between the minds of a human and a rat. And by August, two researchers at the Washington University in St. Louis were able to demonstrate that signals could be transmitted between two human brains, effectively making brain-to-brain interfacing (BBI), and not just brain computer interfacing (BCI) truly possible.

brain-to-brain-interfacing4. Long-Lost Continent Discovered:

In February of this year, geologists from the University of Oslo reported that a small precambrian continent known as Mauritia had been found. At one time, this continent resided between Madagascar and India, but was then pushed beneath the ocean by a multi-million-year breakup spurred by tectonic rifts and a yawning sea-floor. But now, volcanic activity has driven the remnants of the long-lost continent right through to the Earth’s surface.

Not only is this an incredibly rare find, the arrival of this continent to the surface has given geologists a chance to study lava sands and minerals which are millions and even billions of years old. In addition to the volcanic lava sands, the majority of which are around 9 million years old, the Oslo team also found deposits of zircon xenocryst that were anywhere from 660 million to 1.97 billion years old. Studies of these and the land mass will help us learn more about Earth’s deep past.

mauritia5. Cure for HIV Found!:

For decades, medical researchers and scientists have been looking to create a vaccine that could prevent one from being infected with HIV. But in 2013, they not developed several vaccines that demonstrated this ability, but went a step further and found several potential cures. The first bit of news came in March, when researchers at Caltech demonstrated using HIV antibodies and an approach known as Vectored ImmunoProphylaxis (VIP) that it was possible to block the virus.

Then came the SAV001 vaccine from the Schulich School of Medicine & Dentistry at Western University in London, Ontario, which aced clinical trials. This was punctuated by researchers at the University of Illinois’, who in May used the “Blue Waters” supercomputer to developed a new series of computer models to get at the heart of the virus.

HIV-budding-ColorBut even more impressive was the range of potential cures that were developed. The first came in March, where researchers at the Washington University School of Medicine in St. Louis that a solution of bee venom and nanoparticles was capable of killing off the virus, but leaving surrounding tissue unharmed. The second came in the same month, when doctors from Johns Hopkins University Medical School were able to cure a child of HIV thanks to the very early use of antiretroviral therapy (ART).

And in September, two major developments occurred. The first came from Rutgers New Jersey Medical School, where researchers showed that an antiviral foot cream called Ciclopirox was capable of eradicating infectious HIV when applied to cell cultures of the virus. The second came from the Vaccine and Gene Therapy Institute at the Oregon Health and Science University (OHSU), where researchers developed a vaccine that was also able to cure HIV in about 50% of test subjects. Taken together, these developments may signal the beginning of the end of the HIV pandemic.

hiv-aids-vaccine6. Newly Discovered Skulls Alter Thoughts on Human Evolution:

The discovery of an incredibly well-preserved skull from Dmanisi, Georgia has made anthropologists rethink human evolution. This 1.8 million-year old skull has basically suggested that our evolutionary tree may have fewer branches than previously thought. Compared with other skulls discovered nearby, it suggests that the earliest known members of the Homo genus (H. habilis, H.rudolfensis and H. erectus) may not have been distinct, coexisting species, but instead were part of a single, evolving lineage that eventually gave rise to modern humans.

humanEvolution7. Curiosity Confirms Signs of Life on Mars:

Over the past two years, the Curiosity and Opportunity rovers have provided a seemingly endless stream of scientific revelations. But in March of 2013, NASA scientists released perhaps the most compelling evidence to date that the Red Planet was once capable of harboring life. This consisted of drilling samples out of the sedimentary rock in a river bed in the area known as Yellowknife Bay.

Using its battery of onboard instruments, NASA scientists were able to detect some of the critical elements required for life – including sulfur, nitrogen, hydrogen, oxygen, phosphorus, and carbon. The rover is currently on a trek to its primary scientific target – a three-mile-high peak at the center of Gale Crater named Mount Sharp – where it will attempt to further reinforce its findings.

mt_sharp_space8. Scientists Turn Brain Matter Invisible:

Since its inception as a science, neuroanatomy – the study of the brain’s functions and makeup – has been hampered by the fact that the brain is composed of “grey matter”. For one, microscopes cannot look beyond a millimeter into biological matter before images in the viewfinder get blurry. And the common technique of “sectioning” – where a brain is frozen in liquid nitrogen and then sliced into thin sheets for analysis – results in  tissue being deformed, connections being severed, and information being lost.

But a new technique, known as CLARITY, works by stripping away all of a tissue’s light-scattering lipids, while leaving all of its significant structures – i.e. neurons, synapses, proteins and DNA – intact and in place. Given that this solution will allow researchers to study samples of the brains without having to cut them up, it is already being hailed as one of the most important advances for neuroanatomy in decades.


9. Scientists Detect Neutrinos from Another Galaxy:

In April of this year, physicists working at the IceCube South Pole Observatory took part in an expedition which drilled a hole some 2.4 km (1.5 mile) hole deep into an Antarctic glacier. At the bottom of this hole, they managed to capture 28 neutrinos, a mysterious and extremely powerful subatomic particle that can pass straight through solid matter. But the real kicker was the fact that these particles likely originated from beyond our solar system – and possibly even our galaxy.

That was impressive in and off itself, but was made even more so when it was learned that these particular neutrinos are over a billion times more powerful than the ones originating from our sun. So whatever created them would have had to have been cataclysmicly powerful – such as a supernova explosion. This find, combined with the detection technique used to find them, has ushered in a new age of astronomy.

antarctic_expedition

10. Human Cloning Becomes a Reality:

Ever since Dolly the sheep was cloned via somatic cell nuclear transfer, scientists have wondered if a similar technique could be used to produce human embryonic stem cells. And as of May, researchers at Oregon Health and Science University managed to do just that. This development is not only a step toward developing replacement tissue to treat diseases, but one that might also hasten the day when it will be possible to create cloned, human babies.

cloning

11. World’s First Lab Grown Meat:

In May of this year, after years of research and hundred of thousands of dollars invested, researchers at the University of Maastricht in the Netherlands created the world’s first in vitro burgers. The burgers were fashioned from stem cells taken from a cow’s neck which were placed in growth medium, grown into strips of muscle tissue, and then assembled into a burger. This development may prove to be a viable solution to world hunger, especially in the coming decades as the world’s population increases by several billion.

labmeat112. The Amplituhedron Discovered:

If 2012 will be remembered as the year that the Higgs Boson was finally discovered, 2013 will forever be remembered as the year of the Amplituhedron. After many decades of trying to reformulate quantum field theory to account for gravity, scientists at Harvard University discovered of a jewel-like geometric object that they believe will not only simplify quantum science, but forever alters our understanding of the universe.

This geometric shape, which is a representation of the coherent mathematical structure behind quantum field theory, has simplified scientists’ notions of the universe by postulating that space and time are not fundamental components of reality, but merely consequences of the”jewel’s” geometry. By removing locality and unitarity, this discovery may finally lead to an explanation as to how all the fundamental forces of the universe coexist.

amplutihedron_spanThese forces are weak nuclear forces, strong nuclear forces, electromagnetism and gravity. For decades, scientists have been forced to treat them according to separate principles – using Quantum Field Theory to explain the first three, and General Relativity to explain gravity. But now, a Grand Unifying Theory or Theory of Everything may actually be possible.

13. Bioprinting Explodes:

The year of 2013 was also a boon year for bioprinting – namely, using the technology of additive manufacturing to create samples of living tissue. This began in earnest in February, where a team of researchers at Heriot-Watt University in Scotland used a new printing technique to deposit live embryonic stem cells onto a surface in a specific pattern. Using this process, they were able to create entire cultures of tissue which could be morphed into specific types of tissue.

Later that month, researchers at Cornell University used a technique known as “high-fidelity tissue engineering” – which involved using artificial living cells deposited by a 3-D printer over shaped cow cartilage – to create a replacement human ear. This was followed some months later in April when a San Diego-based firm named Organova announced that they were able to create samples of liver cells using 3D printing technology.


And then in August, researchers at Huazhong University of Science and Technology were able to use the same technique create the world first, living kidneys. All of this is pointing the way towards a future where human body parts can be created simply by culturing cells from a donor’s DNA, and replacement organs can be synthetically created, revolutionizing medicine forever.

14. Bionic Machinery Expands:

If you’re a science buff, or someone who has had to go through life with a physical disability, 2013 was also a very big year for the field of bionic machinery. This consisted not only of machinery that could meld with the human body in order to perform fully-human tasks – thus restoring ambulatory ability to people dealing with disabling injuries or diseases – but also biomimetic machinery.

ArgusIIThe first took place in February, where researchers from the University of of Tübingen unveiled the world’s first high-resolution, user-configurable bionic eye. Known officially as the “Alpha IMS retinal prosthesis”, the device helps to restore vision by converted light into electrical signals your retina and then transmitted to the brain via the optic nerve. This was followed in August by the Argus II “retinal prosthetic system” being approved by the FDA, after 20 years of research, for distribution in the US.

Later that same month, the Ecole Polytechnique Federale de Lausanne in Switzerland unveiled the world’s first sensory prosthetic hand. Whereas existing mind-controlled prosthetic devices used nerve signals from the user to control the movements of the limb, this new device sends electrostimulus to the user’s nerves to simulate the sensation of touch.

prosthetic_originalThen in April, the University of Georgia announced that it had created a brand of “smart skin” – a transparent, flexible film that uses 8000 touch-sensitive transistors – that is just as sensitive as the real thing. In July, researchers in Israel took this a step further, showing how a gold-polyester nanomaterial would be ideal as a material for artificial skin, since it experiences changes in conductivity as it is bent.

15. 400,000 Year-Old DNA Confuses Humanity’s Origin Story:

Another discovery made this year has forced anthropologist to rethink human evolution. This occurred in Spain early in December, where a team from the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany recovered a 400,000 year-old thigh bone. Initially thought to be a forerunner of the Neanderthal branch of hominids, it was later learned that it belonged to the little-understood branch of hominins known as Denisovans.

Human-evoThe discordant findings are leading anthropologists to reconsider the last several hundred thousand years of human evolution. In short, it indicates that there may yet be many extinct human populations that scientists have yet to discover. What’s more, there DNA may prove to be part of modern humans genetic makeup, as interbreeding is a possibility.