There’s just no shortage of breakthroughs in the field of biomedicine these days. Whether it’s 3D bioprinting, bionics, nanotechnology or mind-controlled prosthetics, every passing week seems to bring more in the way of amazing developments. And given the rate of progress, its likely going to be just a few years before mortality itself will be considered a treatable condition.
Consider the most recent breakthrough in 3D printing technology, which comes to us from the J.B Speed School of Engineering at the University of Louisville where researchers used a printed model of a child’s hear to help a team of doctors prepare for open heart surgery. Thanks to these printer-assisted measures, the doctors were able to save the life of a 14-year old child.
Philip Dydysnki, Chief of Radiology at Kosair Children’s Hospital, decided to approach the school when he and his medical team were looking at ways of treating Roland Lian Cung Bawi, a boy born with four heart defects. Using images taken from a CT scan, researchers from the school’s Rapid Prototyping Center were able to create and print a 3D model of Roland’s heart that was 1.5 times its actual size.
Built in three pieces using a flexible filament, the printing reportedly took around 20 hours and cost US$600. Cardiothoracic surgeon Erle Austin III then used the model to devise a surgical plan, ultimately resulting in the repairing of the heart’s defects in just one operation. As Austin said, “I found the model to be a game changer in planning to do surgery on a complex congenital heart defect.”
Roland has since been released from hospital and is said to be in good health. In the future, this type of rapid prototyping could become a mainstay for medical training and practice surgery, giving surgeons the options of testing out their strategies beforehand. And be sure to check out this video of the procedure from the University of Louisville:
And in another story, improvements made in the field of bionics are making a big difference for people suffering from diabetes. For people living with type 1 diabetes, the constant need to extract blood and monitor it can be quite the hassle. Hence why medical researchers are looking for new and non-invasive ways to monitor and adjust sugar levels.
Solutions range from laser blood-monitors to glucose-sensitive nanodust, but the field of bionics also offer solutions. Consider the bionic pancreas that was recently trialled among 30 adults, and has also been approved by the US Food and Drug Administration (FDA) for three transitional outpatient studies over the next 18 months.
The device comprises a sensor inserted under the skin that relays hormone level data to a monitoring device, which in turn sends the information wirelessly to an app on the user’s smartphone. Based on the data, which is provided every five minutes, the app calculates required dosages of insulin or glucagon and communicates the information to two hormone infusion pumps worn by the patient.
The bionic pancreas has been developed by associate professor of biomedical engineering at Boston University Dr. Edward Damiano, and assistant professor at Harvard Medical School Dr. Steven Russell. To date, it has been trialled with diabetic pigs and in three hospital-based feasibility studies amongst adults and adolescents over 24-48 hour periods.
The upcoming studies will allow the device to be tested by participants in real-world scenarios with decreasing amounts of supervision. The first will test the device’s performance for five continuous days involving twenty adults with type 1 diabetes. The results will then be compared to a corresponding five-day period during which time the participants will be at home under their own care and without the device.
A second study will be carried out using 16 boys and 16 girls with type 1 diabetes, testing the device’s performance for six days against a further six days of the participants’ usual care routine. The third and final study will be carried out amongst 50 to 60 further participants with type 1 diabetes who are also medical professionals.
Should the transitional trials be successful, a more developed version of the bionic pancreas, based on results and feedback from the previous trials, will be put through trials in 2015. If all goes well, Prof. Damiano hopes that the bionic pancreas will gain FDA approval and be rolled out by 2017, when his son, who has type 1 diabetes, is expected to start higher education.
With this latest development, we are seeing how smart technology and non-invasive methods are merging to assist people living with chronic health issues. In addition to “smart tattoos” and embedded monitors, it is leading to an age where our health is increasingly in our own hands, and preventative medicine takes precedence over corrective.
Repairing severed nerves remains one of the most challenging aspects of modern medicine. In addition to being common, due to spinal injuries, pressure or stretching, the severing or damaging of nerves can lead to a loss of mobility as well as sensation. And up until recently, doctors hoping to repair the damage have been heavily reliant on long-term methods that can be expensive and invasive.
However, Professor George Bittner and his colleagues at the University of Texas at Austin Center for Neuroscience have developed a new and inexpensive procedure to quickly repair severed peripheral nerves. Taking advantage of a mechanism similar to that which permits many invertebrates to regenerate and repair damaged nerves, the new procedure involves applying healing compounds directly to the severed nerve ends.
Trauma to peripheral nerves, which connect the central nervous system to the muscles and sensory organs, is quite common, and is usually the result of excessive pressure or stretching. In most cases, this means that the axon of a nerve – the central bundle of cylindrical sheaths that contains individual nerve cells – is separated from the nerve fiber, leaving the nerve intact but disconnected from the muscle.
Afterward, the nerve cell slowly begins to regrow, and can form a twisted ball of nerve fiber at the cut in the axon. Such nerve scars are called neuroma, and in current medical practice, they are repaired by using microsutures to reconnect the cut ends of the axon and provide a continuous axon to guide the regrowth of the nerve fiber. However, this procedure is extremely delicate, and recovery can take months or even years.
Bittner and his colleagues’ new method involve using a natural healing process to aid in repair and recovery. Already, his team discovered that when a plasma membrane in a cell is damaged, a calcium-mediated healing mechanism begins to draw vesicles (small sacks of lipid membranes) towards the site of the injury. These provide the raw material needed to repair the site.
However, when these vesicles are attracted to the site of a severed axon, both ends of the axon are sealed off by this repair mechanism, preventing regrowth of the nerve. To avoid this problem, the first step of the Texas group’s nerve repair procedure is to bathe the area of the severed nerve with a calcium-free saline solution, thus preventing and even reversing premature healing of the axon ends.
The damaged axons remain open, and can more easily be reattached. This is then done by pulling the severed ends to within a micron of each other, whereupon a small amount of a solution containing polyethylene glycol (PEG) is injected. The PEG removes water from the axonal membranes, allowing the plasma membranes to merge together, thereby healing the axon.
At the same time, the nerve fibers are brought into close enough proximity that they receive chemical messengers from each other, making them believe they are still whole and preventing the death of the disconnected nerve fiber. The severed nerve fibers can then grow together in a short period of time and with relatively good fidelity to the original connectivity of the nerve fibers.
The final step of the procedure is to inject the area with a calcium-rich saline solution, which restarts the vesicle-based repair mechanism, thereby repairing any residual damage to the axonal membrane. At this point, the nerve is structurally repaired, and use of the affected area begins to return within a few hours instead of months.
To test the procedure, Bittner and his colleges experimented on a series of rats that had had their sciatic nerves severed, resulting in paralysis of the affected limb. In each case, once the rats awoke, they were able to move the limbs containing the severed nerves within moments. Normal function was partially restored within a few days, nd 80-90% of the pre-injury function was restored within two to four weeks.
The chemicals used in Bittner’s procedure are common and well understood in interaction with the human body. Because of this, there is no clear obstacle to beginning human clinical trials of the procedure, and teams at Harvard Medical School and Vanderbilt Medical School and Hospitals are currently conducting studies aimed at gaining approval for such trials.
While the procedure developed by Bittner’s group will not apply to the central nervous system or spinal cord injuries, the procedure offers hope to people whose futures include accidents involving damaged nerves. In the past, such people would have to undergo surgery, followed by months or years of physiotherapy (often with inconclusive results).
Now they can look forward to a full recovery that could take as little as a few weeks and cost them comparatively very little. And we, as human beings, would be one step closer to eliminating the term “permanent injury” from our vocabulary!
Cloud computing and the internet are having a profound effect on the field of medicine. As more and more patients have their records digitized and posted in online medical sources, doctor’s are able to better track patient histories, conduct referrals, and make speedier diagnoses. And now, doctors at John Hopkins University are working on a cloud-computing project specifically for children’s brain scans.
By collecting and categorizing thousands of MRI scans from kids with normal and abnormal brains, they say the resulting database will give physicians a sophisticated, “Google-like” search system to help find similar scans as well as the medical records of those children. Such a system could help not only enhance the diagnosis of brain disorders, but the treatment as well, maybe even before clinical symptoms are obvious to the naked eye.
Michael I. Miller, a lead investigator on the project who also heads up the university’s Center for Imaging Science, said in a news release:
If doctors aren’t sure which disease is causing a child’s condition, they could search the data bank for images that closely match their patient’s most recent scan. If a diagnosis is already attached to an image from the data bank, that could steer the physician in the right direction. Also, the scans in our library may help a physician identify a change in the shape of a brain structure that occurs very early in the course of a disease, even before clinical symptoms appear. That could allow the physician to get an early start on the treatment.
Susumu Mori, a radiology professor at the Johns Hopkins School of Medicine and co-lead investigator on what he calls the “biobank,” says that a collection of brain scans of this size will also help neuroradiologists and physicians identify specific malformations far faster than is currently possible.
Mori has spent the past four-plus years working on a clinical database of more than 5,000 whole brain MRI scans of children who’ve come through Johns Hopkins. This project involved indexing anatomical data on 1,000 structural measurements in 250 brain regions that were ultimately sorted into 22 brain disease categories, including infections, psychiatric disorders, epilepsy, and chromosomal abnormalities.
The project, which was made possible by a three-year $600,000 grant from the National Institutes of Health, is still in its pilot stage and available only to physicians and patients within the Johns Hopkins medical system. But the researchers say it could open up and expand to other networks in the coming years. Such an expansion would presumably benefit not only other physicians and patients, but the database itself.
Researchers are also working on a similar project to collect scans of elderly patients to focus on age-related diseases and neurological disorders. Combined with the pediatric databank, this new brain scan archive will not only help recognize established neurological disorders, but could even possibly help identify and classify new ones as well.
But one of the key words here in anonymous. While cloud computing and patient files may raise the specter of privacy for many, the current project maintains patient confidentially. And one can further assume that voluntary compliance will be maintained as databases like these expand. After all, one does not need to know a patient’s name in order to examine what anomalies their brains exhibit.
And in the meantime, be sure to check out this video of Michael Miller explaining the new brain scan project and computational anatomy in greater detail:
Non-invasive medicine is currently one of the fastest growing industries in the world. Thanks to ongoing developments in the fields of nanofabrication, wireless communications, embedded electronics and microsensors, new means are being created all the time that can monitor our health that are both painless and hassle-free.
Consider diabetes, an epidemic that currently affects 8% of the population in the US and is growing worldwide. In October of 2013, some 347 million cases were identified by the World Health Organization, which also claims that diabetes will become the 7th leading cause of death by 2030. To make matters worse, the conditions requires constant blood-monitoring, which is difficult in developing nations and a pain where the means exist.
Hence why medical researchers and companies are looking to create simpler, non-invasive means. Google is one such company, which back in January announced that they are working on a “smart” contact lens that can measure the amount of glucose in tears. By merging a mini glucose sensor and a small wireless chip into a set of regular soft contact lenses, they are looking to take all the pin-pricks out of blood monitoring.
In a recent post on Google’s official blog, project collaborators Brian Otis and Babak Parviz described the technology:
We’re testing prototypes that can generate a reading once per second. We’re also investigating the potential for this to serve as an early warning for the wearer, so we’re exploring integrating tiny LED lights that could light up to indicate that glucose levels have crossed above or below certain thresholds.
And Google is hardly alone in this respect. Due to growing concern and the advancements being made, others are also looking at alternatives to the finger prick, including glucose measures from breath and saliva. A company called Freedom Meditech, for example, is working on a small device that can measure glucose levels with an eye scan.
Their invention is known as the I-SugarX, a handheld device that scans the aqueous humor of eye, yielded accurate results in clinical studies in less than four minutes. John F. Burd, Ph.D., Chief Science Officer of Freedom Meditech, described the process and its benefits in the following way:
The eye can be thought of as an optical window into to body for the painless measurement of glucose in the ocular fluid as opposed to the blood, and is well suited for our proprietary optical polarimetric based measurements. Based on the results of this, and other studies, we plan to begin human clinical studies as we continue our product development.
Between these and other developments, a major trend towards “smart monitoring” is developing and likely to make life easier and cut down on the associated costs of medicine. A smart contact lens or saliva monitor would make it significantly easier to watch out for uncontrolled blood sugar levels, which ultimately lead to serious health complications.
But of course, new techniques for blood-monitoring goes far beyond addressing chronic conditions like diabetes. Diagnosing and controlling the spread of debilitating, potentially fatal diseases is another major area of focus. Much like diabetes, doing regular bloodwork can be a bit difficult, especially when working in developing areas of the world where proper facilities can be hard to find.
But thanks to researchers at Rice University in Houston, Texas, a new test that requires no blood draws is in the works. Relying on laser pulse technology to create a vapor nanobubble in a malaria-infected cell, this test is able to quickly and non-invasively diagnose the disease. While it does not bring medical science closer to curing this increasingly drug-resistant disease, it could dramatically improve early diagnosis and outcomes.
The scanner was invented by Dmitro Lapotko, a physicist, astronomer, biochemist, and cellular biologist who studied laser weapons in Belarus before moving to Houston. Here, he and his colleagues began work on a device that used the same kind of laser and acoustic sensing technology employed on sub-hunting destroyers, only on a far smaller scale and for medical purposes.
Dubbed “vapor nanobubble technology,” the device combines a laser scanner and a fiber-optic probe that detect malaria by heating up hemozoin – the iron crystal byproduct of hemoglobin that is found in malaria cells, but not normal blood cells. Because the hemozoin crystals absorb the energy from the laser pulse, they heat up enough to create transient vapor nanobubbles that pop.
This, in turn, produces a ten-millionth-of-a-second acoustic signature that is then picked up by the device’s fiber-optic acoustic sensor and indicates the presence of the malaria parasite in the blood cells scanned. And because the vapor bubbles are only generated by hemozoin, which is only present in infected cells, the approach is virtually fool-proof.
In an recent issue of Proceedings of the National Academy of Sciences, Lapotko and his research team claimed that the device detected malaria in a preclinical trial on mice where only one red blood cell in a million was infected with zero false positives. In a related school news release, the study’s co-author David Sullivan – a malaria clinician a Johns Hopkins University – had this to say about the new method:
The vapor nanobubble technology for malaria detection is distinct from all previous diagnostic approaches. The vapor nanobubble transdermal detection method adds a new dimension to malaria diagnostics, and it has the potential to support rapid, high-throughput and highly sensitive diagnosis and screening by nonmedical personnel under field conditions.
At present, malaria is one of the world’s deadliest diseases, infecting hundreds of millions of people a year and claiming the lives of more than 600,000. To make matters worse, most the victims are children. All of this combines to make malaria one of the most devastating illness effecting the developing world, comparable only to HIV/AIDS.
By ensuring that blood tests that could detect the virus, and require nothing more than a mobile device that could make the determination quickly, and need only a portable car battery to power it, medical services could penetrate the once-thought impenetrable barriers imposed by geography and development. And this in turn would be a major step towards bringing some of the world’s most infectious diseases to heel.
Ultimately, the aim of non-invasive technology is to remove the testing and diagnostic procedures from the laboratory and make them portable, cheaper, and more user-friendly. In so doing, they also ensure that early detection, which is often the difference between life and death, is far easier to achieve. It also helps to narrow the gap between access between rich people and poor, not to mention developing and developing nations.
These days, advances in prosthetic devices, bionic limbs and exoskeletons continue to advance and amaze. Not only are doctors and medical researchers able to restore mobility and sensation to patients suffering from missing limbs, they are now crossing a threshold where they are able to restore these abilities and faculties to patients suffering from partial or total paralysis.
This should come as no surprise, seeing as how the latest biomedical advances – which involve controlling robotic limbs with brain-computer interfacing – offer a very obvious solution for paralyzed individuals. In their case, no robotic limbs or bionic attachments are necessary to restore ambulatory motion since these were not lost. Instead, what is needed is to restore motor control to compensate for the severed nerves.
Thanks to researchers working at Case Western University in Ohio, a way forward is being proposed. Here, a biomedical team is gearing up to combine the Braingate cortical chip, developed at Brown University, with their own Functional Electric Stimulation (FES) platform. Through this combination, they hope to remove robots from the equation entirely and go right to the source.
It has long been known that electrical stimulation can directly control muscles, but attempts to do this in the past artificially has often been inaccurate (and therefore painful and potentially damaging) to the patient. Stimulating the nerves directly using precisely positioned arrays is a much better approach, something that another team at Case Western recently demonstrated thought their “nerve cuff electrode”.
This electrode is a direct stimulation device that is small enough to be placed around small segments of nerve. The Western team used the cuff to provide an interface for sending data from sensors in the hand back to the brain using sensory nerves in the arm. With FES, the same kind of cuff electrode can also be used to stimulate nerves going the other direction, in other words, to the muscles.
The difficulty in such a scheme, is that even if the motor nerves can be physically separated from the sensory nerves and traced to specific muscles, the exact stimulation sequences needed to make a proper movement are hard to find. To achieve this, another group at Case Western has developed a detailed simulation of how different muscles work together to control the arm and hand.
Their model consists of 138 muscle elements distributed over 29 muscles, which act on 11 joints. The operational procedure is for the patient to watch the image of the virtual arm while they naturally generate neural commands that the BrainGate chip picks up to move the arm. In practice, this means trying to make the virtual arm touch a red spot to make it turn green.
Currently in clinical trials, the Braingate2 chip is being developed with the hope of not only stimulating muscles, but generating the same kinds of feedback and interaction that real muscle movement creates. The eventual plan is that the patient and the control algorithm will learn together in tandem so that a training screen will not be needed at all and a patient will be able to move on their own without calibrating the device.
But at the same time, biotech enhancements that are restoring sensation to amputee victims are also improving apace. Consider the bionic hand developed by Silvestro Micerna of the École Polytechnique Fédérale de Lausanne in Switzerland. Unlike previous bionic hands, which rely on electrodes to receive nerve signals to control the hand’s movement, his device sends electronic signals back to simulate the feeling of touch.
Back in February of 2013, Micerna and his research team began testing their bionic hand, and began clinical trials on a volunteer just last month. Their volunteer, a man named Dennis Aabo Sørensen from Denmark, lost his arm in a car accident nine years ago, and has since become the first amputee to experience artificially-induced sensation in real-time.
In a laboratory setting wearing a blindfold and earplugs, Sørensen was able to detect how strongly he was grasping, as well as the shape and consistency of different objects he picked up with his prosthetic. Afterwards, Sørensen described the experience to reporters, saying:
The sensory feedback was incredible. I could feel things that I hadn’t been able to feel in over nine years. When I held an object, I could feel if it was soft or hard, round or square.
The next step will involve miniaturizing the sensory feedback electronics for a portable prosthetic, as well as fine-tuning the sensory technology for better touch resolution and increased awareness about the movement of fingers. They will also need to assess how long the electrodes can remain implanted and functional in the patient’s nervous system, though Micerna’s team is confident that they would last for many years.
Micerna and his team were also quick to point out that Sørensen’s psychological strength was a major asset in the clinical trial. Not only has he been forced to adapt to the loss of his arm nine years ago, he was also extremely willing to face the challenge of having experienced touch again, but for only a short period of time. But as he himself put it:
I was more than happy to volunteer for the clinical trial, not only for myself, but to help other amputees as well… There are two ways you can view this. You can sit in the corner and feel sorry for yourself. Or, you can get up and feel grateful for what you have.
The study was published in the February 5, 2014 edition of Science Translational Medicine, and represents a collaboration called Lifehand 2 between several European universities and hospitals. And although a commercially-available sensory-enhanced prosthetic may still be years away, the study provides the first step towards a fully-realizable bionic hand.
Yes, between implantable electronics that can read out brainwaves and nerve impulses, computers programs that are capable of making sense of it all, and robotic limbs that are integrated to these machines and our bodies, the future is looking very interesting indeed. In addition to restoring ambulatory motion and sensation, we could be looking at an age where there is no such thing as “permanent injury”.
And in the meantime, be sure to check out this video of Sørensen’s clinical trial with the EPFL’s bionic hand:
If there’s one thing medical science is looking to achieve, it’s ways of dealing with sickness and injuries that are less invasive. And now more than ever, researchers are looking to the natural world for solutions. Whether it is working with the bodies own components to promote healing, or using technologies that imitate living organism, the future of medicine is all about engineered-natural solutions.
Consider the elastic glue developed by associate professor Jeffrey Karp, a Canadian-born medical researcher working at Harvard University. Created for heart surgery, this medical adhesive is designed to replace sutures and staples as the principle means of sealing incisions and defects in heart tissue. But the real kicker? The glue was inspired by sticky natural secretions of slugs.
Officially known as hydrophobic light-activated adhesive (HLAA), the glue was developed in a collaboration between Boston Children’s Hospital, MIT, and Harvard-affiliated Brigham and Women’s Hospital. And in addition to being biocompatible and biodegradable (a major plus in surgery), it’s both water-resistant and elastic, allowing it to stretch as a beating heart expands and contracts.
All of this adds up to a medical invention that is far more user-friendly than stitches and staples, does not have to be removed, and will not cause complications. On top of all that, it won’t complicate healing by restricting the heart’s movements, and only becomes active when an ultraviolet light shines on it, so surgeons can more accurately bind the adhesive exactly where needed.
The technology could potentially be applied not just to congenital heart defects, but to a wide variety of organs and other body parts. In an recent interview with CBC Radio’s Quirks & Quarks, Karp explained the advantages of the glue:
Sutures and staples really are not mechanically similar to the tissues in the body, so they can induce stress on the tissue over time. This is a material that’s made from glycerol and sebacic acid, both of which exist in the body and can be readily metabolized. What happens over time is that this material will degrade. Cells will invade into it and on top of it, and ideally the hole will remain closed and the patient won’t require further operations.
In lab tests, biodegradable patches coated with HLAA were applied to holes in the hearts of live pigs. Despite the high pressure of the blood flowing through the organs, the patches maintained a leakproof seal for the 24-hour test period. HLAA is now being commercially developed by Paris-based start-up Gecko Biomedical, which hopes to have it on the market within two to three years.
In another recent development, scientists at the Université de Montréal have created a new DNA clamp capable of detecting the genetic mutations responsible for causing cancers, hemophilia, sickle cell anemia and other diseases. This clamp is not only able to detect mutations more efficiently than existing techniques, it could lead to more advanced screening tests and more efficient DNA-based nanomachines for targeted drug delivery.
To catch diseases at their earliest stages, researchers have begun looking into creating quick screening tests for specific genetic mutations that pose the greatest risk of developing into life-threatening illnesses. When the nucleotide sequence that makes up a DNA strand is altered, it is understood to be a mutation, which specific types of cancers can be caused by.
To detect this type of mutation and others, researchers typically use molecular beacons or probes, which are DNA sequences that become fluorescent on detecting mutations in DNA strands. The team of international researchers that developed the DNA clamp state that their diagnostic nano machine allows them to more accurately differentiate between mutant and non-mutant DNA.
According to the research team, the DNA clamp is designed to recognize complementary DNA target sequences, binds with them, and form a stable triple helix structure, while fluorescing at the same time. Being able to identify single point mutations more easily this way is expected to help doctors identify different types of cancer risks and inform patients about the specific cancers they are likely to develop.
Diagnosing cancer at a genetic level could potentially help arrest the disease, before it even develops properly. Alexis Vallée-Bélisle, a Chemistry Professor at the Université de Montréal, explained the long-term benefits of this breakthrough in a recent interview:
Cancer is a very complex disease that is caused by many factors. However, most of these factors are written in DNA. We only envisage identifying the cancers or potential of cancer. As our understanding of the effect of mutations in various cancer will progress, early diagnosis of many forms of cancer will become more and more possible.
Currently the team has only tested the probe on artificial DNA, and plans are in the works to undertake testing on human samples. But the team also believes that the DNA clamp will have nanotechnological applications, specifically in the development of machines that can do targeted drug-delivery.
For instance, in the future, DNA-based nanomachines could be assembled using many different small DNA sequences to create a 3D structure (like a box). When it encounters a disease marker, the box could then open up and deliver the anti-cancer drug, enabling smart drug delivery. What’s more, this new DNA clamp could prove intrinsic in that assembly process.
Professor Francesco Ricci of the University of Rome, who collaborated on the project, explained the potential in a recent interview:
The clamp switches that we have designed and optimized can recognize a DNA sequence with high precision and high affinity. This means that our clamp switches can be used, for example, as super-glue to assemble these nano machines and create a better and more precise 3D structure that can, for example, open in the presence of a disease marker and release a drug.
Hmm, glues inspired by mollusc secretions, machines made from DNA. Medical technology is looking less like technology and more like biology every day now!
Gauging what life will be like down the road based on the emerging trends of today is something that scientists and speculative minds have been doing since the beginning of time. But given the rapid pace of change in the last century – and the way that it continues to accelerate – predicting future trends has become something of a virtual necessity today.
And the possibilities that are expected for the next generation are both awe-inspiring and cause for concern. On the one hand, several keen innovations are expected to become the norm in terms of transportation, education, health care and consumer trends. On the other, the growing problems of overpopulation, urbanization and Climate Change are likely to force some serious changes.
Having read through quite a bit of material lately that comes from design firms, laboratories, and grant funds that seek to award innovation, I decided to do a post that would take a look at how life is expected to change in the coming decades, based on what we are seeing at work today. So here we go, enjoy the ride, and remember to tip the driver!
Housing: When it comes to designing the cities of the future – where roughly 5 of the worlds 8.25 billion people are going to live – meeting the basic needs of all these folks is complicated by the need to meet them in a sustainable way. Luckily, people all across the world are coming together to propose solutions to this problem, ranging from the small and crafty to the big and audacious.
Consider that buildings of the future could be coated with Smart Paint, a form of pigment that allows people to change the color of their domicile simply by pushing a button. Utilizing nano-particles that rearrange themselves to absorb a different part of the spectrum, the paint is able to reflect whatever wavelength of visible light the user desires, becoming that color and removing the need for new coats of paint.
And consider that apartments and houses in this day could be lighted by units that convert waste light energy from their light bulbs back into functional ambient light. This is the idea behind the Trap Light, a lamp that comes equipped with photoluminescent pigments embedded directly into the glass body. Through this process, 30 minutes of light from an incandescent or LED light bulb provides a few hours of ambient lighting.
And in this kind of city, the use of space and resources has come to be very efficient, mainly because it has had to. In terms of low-rent housing, designs like the Warsaw-inspired Keret House are very popular, a narrow, 14-sqaure meter home that still manages to fit a bathroom, kitchen and bedroom. Being so narrow, city planners are able to squeeze these into the gaps between older buildings, its walls and floors snapping together like Lego.
When it comes to other, larger domiciles (like houses and apartment blocks), construction is likely to become a much more speedy and efficient process – relying on the tools of Computer-Assisted Design (CAD) and digital fabrication (aka. the D-process). Basically, the entire fabrication process is plotted in advance on computer, and then the pieces are tailor made in the factory and snapped together on site.
And lets not forget anti-gravity 3-D printing as a means of urban assembly, as proposed by architecture students from the Joris Laarman Lab in Amsterdam. Using quick-hardening materials and dispensed by robot-driven printers, entire apartment blocks – from electronic components to entire sections of wall – within a few days time. Speedier, safer and more efficient than traditional construction.
Within these buildings, water is recycled and treated, with grey water used to fertilize crops that are grown in house. Using all available spaces – dedicated green spaces, vertical agriculture, and “victory gardens” on balconies – residents are able to grow their own fruits and vegetables. And household 3-D food printers will dispense tailor-made treats, from protein-rich snacks and carb crackers to chocolate and cakes.
And of course, with advances in smart home technology, you can expect that your appliances, thermostat, and display devices will all be predictive and able to anticipate your needs for the day. What’s more, they will all be networked and connected to you via a smartphone or some other such device, which by 2030, is likely to take the form of a smartwatch, smartring or smartbracelet.
Speaking of which…
Smart Devices and Appliances:
When it comes to living in the coming decades, the devices we use to manage our everyday lives and needs will have evolved somewhat. 3-D printing is likely to be an intrinsic part of this, manufacturing everything from food to consumer products. And when it comes to scanning things for the sake of printing them, generating goods on demand, handheld scanners are likely to become all the rage.
That’s where devices like the Mo.Mo. (pictured above) will come into play. According to Futurist Forum, this molecular scanning device scans objects around your house, tells you what materials they’re made from, and whether they can be re-created with a 3-D printer. Personal, household printers are also likely to be the norm, with subscriptions to open-source software sites leading to on-demand household manufacturing.
And, as already mentioned, everything in the home and workplace is likely to be connected to your person through a smart device or embedded chips. Consistent with the concept of the “Internet of Things”, all devices are likely to be able to communicate with you and let you know where they are in real time. To put that in perspective, imagine SIRI speaking to you in the form of your car keys, telling you they are under the couch.
Telepresence, teleconferencing and touchscreens made out of every surface are also likely to have a profound effect. When a person wakes in the morning, the mirror on the wall will have displays telling them the date, time, temperature, and any messages and emails they received during the night. When they are in the shower, the wall could comforting images while music plays. This video from Corning Glass illustrates quite well:
And the current range of tablets, phablets and smartphones are likely to be giving way to flexible, transparent, and ultralight/ultrathin handhelds and wearables that use projection and holographic technology. These will allow a person to type, watch video, or just interface with cyberspace using augmented reality instead of physical objects (like a mouse or keyboard).
And devices which can convert, changing from a smartphone to a tablet to a smartwatch (and maybe even glasses) are another predicted convenience. Relying on nanofabrication technology, Active-Matrix Organic Light-Emitting Diode (AMOLED) technology, and touch-sensitive surfaces, these devices are sure to corner the market of electronics. A good example is Nokia’s Morph concept, shown here:
Energy Needs: In the cities of the near-future, how we generate electricity for all our household appliances, devices and possibly robots will be a going concern. And in keeping with the goal of sustainability, those needs are likely to be met by solar, wind, piezoelectric, geothermal and tidal power wherever possible. By 2030, buildings are even expected to have arrays built in to them to ensure that they can meet their own energy needs independently.
This could look a lot like the Strawscraper (picture above), where thousands of fronds utilize wind currents to generate electricity all day long; or fields filled with Windstalks – where standing carbon-fiber reinforced poles generate electricity by simply swaying with the wind. Wind farms, or wind tunnels and turbines (as envisioned with the Pertamina Energy Tower in Jakarta) could also be used by buildings to do the same job.
In addition, solar panels mounted on the exterior would convert daylight into energy. Assuming these buildings are situated in low-lying areas, superheated subterranean steam could easily be turned into sources of power through underground pipes connected to turbines. And for buildings located near the sea, turbines placed in the harbor could do the same job by capturing the energy of the tides.
Furthermore, piezoelectric devices could be used to turn everyday activity into electricity. Take the Pavegen as an example, a material composed of recycled tires and piezoelectric motors that turns steps into energy. Equipping every hallway, stairwell and touch surface with tensile material and motors, just about everything residents do in a building could become a source of added power.
On top of that, piezoelectric systems could be embedded in roads and on and off ramps, turning automobile traffic into electrical power. In developed countries, this is likely to take the form of advanced materials that create electrical charges when compressed. But for developing nations, a simple system of air cushions and motors could also be effective, as demonstrated by Macías Hernández’ proposed system for Mexico City.
And this would seem like a good segue into the issue of…
Mass Transit: According to UN surveys, roughly 60% of the world’s population will live in cities by the year 2030. Hopefully, the 5.1 billion of us negotiating tight urban spaces by then will have figured out a better way to get around. With so many people packed into dense urban environments, it is simply not practical for all these individuals to rely on smog-emitting automobiles.
For the most part, this can be tackled by the use of mass transit that is particularly fast and efficient, which are the very hallmarks of maglev trains. And while most current designs are already speedy and produce a smaller carbon footprint than armies of cars, next-generation designs like the Hyperloop, The Northeast Maglev (TNEM), and the Nagoya-Tokyo connector are even more impressive.
Dubbed by Elon Musk as the “fifth form” of transportation, these systems would rely on linear electric motors, solar panels, and air cushions to achieve speeds of up to 1290 kilometers per hour (800 mph). In short, they would be able to transport people from Los Angeles and San Francisco in 30 minutes, from New York to Washington D.C. in 60 minutes, and from Nagoya to Tokyo in just 41.
When it comes to highways, future designs are likely to take into account keeping electric cars charged over long distances. Consider the example that comes to us from Sweden, where Volvo is also working to create an electric highway that has embedded electrical lines that keep cars charged over long distances. And on top of that, highways in the future are likely to be “smart”.
For example, the Netherlands-based Studio Roosegaarde has created a concept which relies on motion sensors to detect oncoming vehicles and light the way for them, then shuts down to reduce energy consumption. Lane markings will use glow-in-the-dark paint to minimize the need for lighting, and another temperature-sensitive paint will be used to show ice warnings when the surface is unusually cold.
In addition, the road markings are expected to have longer-term applications, such as being integrated into a robot vehicle’s intelligent monitoring systems. As automated systems and internal computers become more common, smart highways and smart cars are likely to become integrated through their shared systems, taking people from A to B with only minimal assistance from the driver.
And then there’s the concept being used for the future of the Pearl River Delta. This 39,380 square-km (15,200 square-mile) area in southeastern China encompasses a network of rapidly booming cities like Shenzhen, which is one of the most densely populated areas in the world. It’s also one of the most polluted, thanks to the urban growth bringing with it tons of commuters, cars, and vehicle exhaust.
That’s why NODE Architecture & Urbanism – a Chinese design firm – has come up with a city plan for 2030 that plans put transportation below ground, freeing up a whole city above for more housing and public space. Yes, in addition to mass transit – like subways – even major highways will be relegated to the earth, with noxious fumes piped and tunneled elsewhere, leaving the cityscape far less polluted and safer to breathe.
Personal cars will not be gone, however. Which brings us to…
Personal Transit: In the future, the majority of transport is likely to still consist of automobiles, albeit ones that overwhelmingly rely on electric, hydrogen, biofuel or hybrid engines to get around. And keeping these vehicles fueled is going to be one of the more interesting aspects of future cities. For instance, electric cars will need to stay charged when in use in the city, and charge stations are not always available.
That’s where companies like HEVO Power come into play, with its concept of parking chargers that can offer top-ups for electric cars. Having teamed up with NYU Polytechnic Institute to study the possibility of charging parked vehicles on the street, they have devised a manhole c0ver-like device that can be installed in a parking space, hooked up to the city grid, and recharge batteries while commuters do their shopping.
And when looking at individual vehicles, one cannot underestimate the role by played by robot cars. Already, many proposals are being made by companies like Google and Chevrolet for autonomous vehicles that people will be able to summon using their smartphone. In addition, the vehicles will use GPS navigation to automatically make their way to a destination and store locations in its memory for future use.
And then there’s the role that will be played by robotaxis and podcars, a concept which is already being put to work in Masdar Eco City in the United Arab Emirates, San Diego and (coming soon) the UK town of Milton Keynes. In the case of Masdar, the 2GetThere company has built a series of rails that can accommodate 25,000 people a month and are consistent with the city’s plans to create clean, self-sustaining options for transit.
In the case of San Diego, this consists of a network known as the Personal Rapid Transit System – a series of on-call, point to point transit cars which move about on main lines and intermediate stations to find the quickest route to a destination. In Britian, similar plans are being considered for the town of Milton Keynes – a system of 21 on-call podcars similar to what is currently being employed by Heathrow Airport.
But of course, not all future transportation needs will be solved by MagLev trains or armies of podcars. Some existing technologies – such as the bicycle – work pretty well, and just need to be augmented. Lightlane is a perfect example of this, a set of lasers and LED lights that bikers use to project their own personal bike lane from under the seat as they ride.
And let’s not forget the Copenhagen Wheel, a device invented by MIT SENSEable City Lab back in 2009 to electrify the bicycle. Much like other powered-bicycle devices being unveiled today, this electric wheel has a power assist feature to aid the rider, a regenerative braking system that stores energy, and is controlled by sensors in the peddles and comes with smart features can be controlled via a smartphone app.
On top of all that, some research actually suggests that separating modes of transportation – bike lanes, car lanes, bus lanes, etc. – actually does more harm than good to the people using them. In Europe, the traffic concept known as “shared spaces” actually strips paths of traffic markings and lights, and allow walkers and drivers to negotiate their routes on their own.
Shared spaces create more consideration and consciousness for other people using them, which is why the Boston architecture firm Höweler + Yoon designed the “Tripanel” as part of their larger vision for the Boston-Washington corridor (aka. “Boswash”). The Tripanel features a surface that switches among grass, asphalt, and photovoltaic cells, offering a route for pedestrians, bikers, and electric cars.
Education:
When it comes to schooling ourselves and our children, the near future is likely to see some serious changes, leading to a virtual reinventing of educational models. For some time now, educators have been predicting how the plurality of perspectives and the rise of a globalized mentality would cause the traditional mode of learning (i.e. centralized schools, transmission learning) to break down.
And according to other speculative thinkers, such as Salim Ismail – the director of Singularity University – education will cease being centralized at all and become an “on-demand service”. In this model, people will simply “pull down a module of learning”, and schooldays and classrooms will be replaced by self-directed lessons and “microlearning moments”.
In this new learning environment, teleconferencing, telepresence, and internet resources are likely to be the main driving force. And while the size and shape of future classrooms is difficult to predict, it is likely that classroom sizes will be smaller by 2030, with just a handful of students using portable devices and display glasses to access information while under the guidance of a teacher.
At the same time, classrooms are likely to be springing up everywhere, in the forms of learning annexes in apartment buildings, or home-school environments. Already, this is an option for distance education, where students and teachers are connected through the internet. With the addition of more sophisticated technology, and VR environments, students will be able to enter “virtual classrooms” and connect across vast distances.
According to Eze Vidra, the head of Google Entrepreneurs Europe: “School kids will learn from short bite-sized modules, and gamification practices will be incorporated in schools to incentivize children to progress on their own.” In short, education will become a self-directed, or (in the case of virtual environments) disembodied experienced that are less standardized, more fun, and more suited to individual needs.
Health: Many experts believe that medicine in the future is likely to shift away from addressing illness to prevention. Using thin, flexible, skin-mounted, embedded, and handheld sensors, people will be able to monitor their health on a daily basis, receiving up-to-date information on their blood pressure, cholesterol, kidney and liver values, and the likelihood that they might contract diseases in their lifetime.
All of these devices are likely to be bundled in one way or another, connected via smartphone or other such device to a person’s home computer or account. Or, as Ariel Schwatz of CoExist anticipates, they could come in the form of a “Bathroom GP”, where a series of devices like a Dr.Loo and Dr. Sink measure everything from kidney function to glucose levels during a routine trip.
Basically, these smart toilets and sinks screen for illnesses by examining your spittle, feces, urine and other bodily fluids, and then send that data to a microchip embedded inside you or on a wristband. This info is analyzed and compared to your DNA patterns and medical records to make sure everything is within the normal range. The chip also measures vital signs, and Dr Mirror displays all the results.
However, hospitals will still exist to deal with serious cases, such as injuries or the sudden onset of illnesses. But we can also expect them to be augmented thanks to the incorporation of new biotech, nanotech and bionic advances. With the development of bionic replacement limbs and mind-controlled prosthetics proceeding apace, every hospital in the future is likely to have a cybernetics or bioenhancement ward.
What’s more, the invention of bioprinting, where 3-D printers are able to turn out replacement organic parts on demand, is also likely to seriously alter the field of medical science. If people are suffering from a failing heart, liver, kidney, or have ruined their knees or other joints, they can simply put in at the bioprinting lab and get some printed replacement parts prepared.
And as a final, encouraging point, diseases like cancer and HIV are likely to be entirely curable. With many vaccines that show the ability to not only block, but even kill, the HIV virus in production, this one-time epidemic is likely to be a thing of the past by 2030. And with a cure for cancer expected in coming years, people in 2030 are likely to view it the same way people view polio or tetanus today. In short, dangerous, but curable!
Buying/Selling: When it comes to living in 2030, several trends are expected to contribute to people’s economic behavior. These include slow economic growth, collaborative consumption, 3-D printing, rising costs, resource scarcity, an aging population, and powerful emerging economies. Some of these trends are specific, but all of them will effect the behavior of future generations, mainly because the world of the future will be even more integrated.
As already noted, 3-D printers and scanners in the home are likely to have a profound effect on the consumer economy, mainly by giving rise to an on-demand manufacturing ethos. This, combined with online shopping, is likely to spell doom for the department store, a process that is already well underway in most developed nations (thanks to one-stop shopping).
However, the emergence of the digital economy is also creating far more in the way of opportunities for micro-entrepreneurship and what is often referred to as the “sharing economy”. This represents a convergence between online reviews, online advertising of goods and services, and direct peer-to-peer buying and selling that circumvents major distributors.
This trend, which is not only reaching back in time to reestablish a bartering economy, but is also creating a “trust metric”, whereby companies, brand names, and even individuals are being measured by to their reputation, which in turn is based on their digital presence and what it says about them. Between a “sharing economy” and a “trust economy”, the economy of the future appears highly decentralized.
Further to this is the development of cryptocurrencies, a digital medium of exchange that relies solely on consumer demand to establish its value – not gold standards, speculators or centralized banks. The first such currency was Bitcoin, which emerged in 2009, but which has since been joined by numerous others like Litecoin, Namecoin, Peercoin, Ripple, Worldcoin, Dogecoin, and Primecoin.
In this especially, the world of 2030 is appearing to be a very fluid place, where wealth depends on spending habits and user faith alone, rather than the power of governments, financial organizations, or centralized bureaucracies. And with this movement into “democratic anarchy” underway, one can expect the social dynamics of nations and the world to change dramatically.
Space Travel!: This last section is of such significance that it simply must end with an exclamation mark. And this is simply because by 2030, many missions and projects that will pave the way towards a renewed space age will be happening… or not. It all comes down to whether or not the funding is made available, public interest remains high, and the design and engineering concepts involved hold true.
However, other things are likely to become the norm, such as space tourism. Thanks to visionaries like World View and Richard Branson (the pioneer of space tourism with Virgin Galactic), trips to the lower atmosphere are likely to become a semi-regular occurrence, paving the way not only for off-world space tourism, but aerospace transit across the globe as well.
Private space exploration will also be in full-swing, thanks to companies like Google’s Space X and people like Elon Musk. This year, Space X is preparing for the first launch of it’s Falcon Heavy rocket, a move which will bring affordable space flight that much closer. And by 2030, affordability will be the hallmarks of private ventures into space, which will likely include asteroid mining and maybe the construction of space habitats.
2030 is also the year that NASA plans to send people to Mars, using the Orion Multi-Purpose Crew Vehicle and a redesigned Saturn V rocket. Once there, the crew will conduct surface studies and build upon the vast legacy of the Spirit, Opportunity and Curiosity Rovers to determine what Mars once looked like. This will surely be a media event, the likes of which has not been seen since the Moon Landing.
Speaking of media events, by 2030, NASA may not even be the first space agency or organization to set foot on Mars. Not if Mars One, a nonprofit organization based in the Netherlands, get’s its way and manages to land a group of colonists there by 2023. And they are hardly alone, as Elon Musk has already expressed an interest in establishing a colony of 80,000 people on the Red Planet sometime in the future.
And Inspiration Mars, another non-profit organization hosted by space adventurist Dennis Tito, will have already sent an astronaut couple on a round-trip to Mars and back (again, if all goes as planned). The mission, which is currently slated for 2018 when the planets are in alignment, will therefore be a distant memory, but will serve as an example to all the private space ventures that will have followed.
In addition to Mars, one-way trips are likely to be taking place to other celestial bodies as well. For instance, Objective Europa – a non-profit made up of scientists, conceptual artists, and social-media experts – plans to send a group of volunteers to the Jovian moon of Europa as well. And while 2030 seems a bit soon for a mission, it is likely that (if it hasn’t been scrapped) the program will be in the advanced stages by then.
NASA and other space agencies are also likely to be eying Europa at this time and perhaps even sending ships there to investigate the possibility of life beneath it’s icy surface. Relying on recent revelations about the planet’s ice sheet being thinnest at the equator, a lander or space penetrator is sure to find its way through the ice and determine once and for all if the warm waters below are home to native life forms.
By 2030, NASA’s MAVEN and India’s MOM satellites will also have studied the Martian atmosphere, no doubt providing a much fuller picture of its disappearance. At the same time, NASA will have already towed an asteroid to within the Moon’s orbit to study it, and begun constructing an outpost at the L2 Lagrange Point on the far side of the Moon, should all go as planned.
And last, but certainly not least, by 2030, astronauts from NASA, the ESA, and possibly China are likely to be well on their way towards the creation of a permanent outpost on the Moon. Using a combination of 3-D printing, robots, and sintering technology, future waves of astronauts and settlers will have permanent domes made directly out of regolith with which to conduct research on the Lunar surface.
All of these adventures will help pave the way to a future where space tourism to other planets, habitation on the Moon and Mars, and ventures to the asteroid belt (which will solve humanity’s resource problem indefinitely), will all be the order of the day.
Summary: To break it all down succinctly, the world of 2030 is likely to be rather different than the one we are living in right now. At the same time though, virtually all the developments that characterize it – growing populations, bigger cities, Climate Change, alternative fuels and energy, 3-D printing, cryptocurrencies, and digital devices and communications – are already apparent now.
Still, as these trends and technologies continue to expand and are distributed to more areas of the world – not to mention more people, as they come down in price – humanity is likely to start taking them for granted. The opportunities they open, and the dependency they create, will have a very deterministic effect on how people live and how the next generation will be shaped.
All in all, 2030 will be a very interesting time because it will be here that so many developments – the greatest of which will be Climate Change and the accelerating pace of technological change – will be on the verge of reaching the tipping point. By 2050, both of these factors are likely to come to a head, taking humanity in entirely different directions and vying for control of our future.
Basically, as the natural environment reels from the effects of rising temperatures and an estimated CO2 concentration of 600 ppm in the upper atmosphere, the world will come to be characterized by famine, scarcity, shortages, and high mortality. At the same time, the accelerating pace of technology promises to lead to a new age where abundance, post-scarcity and post-mortality are the norm.
So in the end, 2030 will be a sort of curtain raiser for the halfway point of the 21st century, during which time, humanity’s fate will have become largely evident. I’m sure I’m not alone in hoping things turn out okay, because our children are surely expecting to have children of their own, and I know they would like to leave behind a world the latter could also live in!
Since it’s inception, bioprinting has offered medical science and astounding range of applications, with new being added every day. In just the past few years, researchers have found ways to create 3-D printed cartilage, replacement skin, and even miniature kidneys and livers using stem cells. And now, with this latest development, doctor’s may be able to “draw” replacement tissue as easily as they scrawl their signatures on a prescription pad.
It’s known as the BioPen, a handheld surgical device that works a little like a mini-3-D printer may soon be used to help repair damaged bones. Developed by Austrian researchers, the pen allows a surgeon to draw layers of stem cells directly at the site of an injury. Much like a a 3-D printer deposits plastic one layer at a time, the BioPen deposits gel in layers to create a 3-D structure.
After filling the damaged bone with the cells – mixed with a biodegradable seaweed extract to hold everything together- an ultraviolet light on the pen sets the gel in place. After the cells are in place, they multiply and eventually form functioning tissue. The device can also be used to apply growth factors to stimulate cell growth and other drugs (like cortisone) directly to where they are needed.
University of Wollongong professor Gordon Wallace, one of the researchers who is working on the project along with a team from the University of Melbourne, expressed the benefits of the device this way:
Biology works in 3-D. The ability to provide an appropriate structural environment for the stem cells enables more effective development into the appropriate tissue.
In the past, surgeons might have just injected stem cells to the desired area. But now, using the pen to build a small scaffold out of the gel, the cells can be better protected and more likely to survive. The researchers say it’s also easier to be precise with the pen in hand, and the whole process takes less time than surgeries would have in the past.
To further illustrate the uses and applications of additive manufacturing, the prototype itself was built in the researchers’ lab using a 3-D printer. According to Wallace, next-generation fabrication techniques not only made it possible to easily build the pen, but they also make it possible to quickly iterate new versions of the hardware.
And while their partners at St. Vincent’s Hospital in Melbourne are working on optimizing the cell material, Wallace and his team of researchers will begin conducting animal trials with the BioPen, beginning later this year. If all goes well, the device could be undergoing human trials sometime in 2015, and available in hospitals in just a few years time.
And combined with other procedures that can generate replacement tissue (eyes, organs, skin), we will be looking at the age of biomedicine in full bloom!
Here we have two more stories from last year that I find I can’t move on without posting about them. And considering just how relevant they are to the field of biomedicine, there was no way I could let them go unheeded. Not only are developments such as these likely to save lives, they are also part of a much-anticipated era where mortality will be a nuisance rather than an inevitability.
The first story comes to us from the University of New South Wales (UNSW) in Australia and the Harvard Medical School, where a joint effort achieved a major step towards the dream of clinical immortality. In the course of experimenting on mice, the researchers managed to reverse the effects of aging in mice using an approach that restores communication between a cell’s mitochondria and nucleus.
Mitochondria are the power supply for a cell, generating the energy required for key biological functions. When communication breaks down between mitochondria and the cell’s control center (the nucleus), the effects of aging accelerate. Led by David Sinclair, a professor from UNSW Medicine at Harvard Medical School, the team found that by restoring this molecular communication, aging could not only be slowed, but reversed.
Responsible for this breakdown is a decline of the chemical Nicotinamide Adenine Dinucleotide (or NAD). By increasing amounts of a compound used by the cell to produce NAD, Professor Sinclair found that he and his team could quickly repair mitochondrial function. Key indicators of aging, such as insulin resistance, inflammation and muscle wasting, showed extensive improvement.
In fact, the researchers found that the tissue of two-year-old mice given the NAD-producing compound for just one week resembled that of six-month-old mice. They said that this is comparable to a 60-year-old human converting to a 20-year-old in these specific areas. As Dr Nigel Turner, an ARC Future Fellow from UNSW’s Department of Pharmacology and co-author of the team’s research paper, said:
It was shocking how quickly it happened. If the compound is administered early enough in the aging process, in just a week, the muscles of the older mice were indistinguishable from the younger animals.
The technique has implications for treating cancer, type 2 diabetes, muscle wasting, inflammatory and mitochondrial diseases as well as anti-aging. Sinclair and his team are now looking at the longer-term outcomes of the NAD-producing compound in mice and how it affects them as a whole. And with the researchers hoping to begin human clinical trials in 2014, some major medical breakthroughs could be just around the corner.
In another interesting medical story, back in mid-December, a 75 year-old man in Paris became the recipient of the world’s first Carmat bioprosthetic artificial heart. Now technically, artificial hearts have been in use since the 1980’s. But what sets this particular heart apart, according to its inventor – cardiac surgeon Alain Carpentier – is the Carmat is the first artificial heart to be self-regulating.
In this case, self-regulating refers to the Carmat’s ability to speed or slow its flow rate based on the patient’s physiological needs. For example, if they’re performing a vigorous physical activity, the heart will respond by beating faster. This is made possible via “multiple miniature embedded sensors” and proprietary algorithms running on its integrated microprocessor. Power comes from an external lithium-ion battery pack worn by the patient, and a fuel cell is in the works.
Most other artificial hearts beat at a constant unchanging rate, which means that patients either have to avoid too much activity, or risk becoming exhausted quickly. In the course of its human trials, it will be judged based on its ability to keep patients with heart failure alive for a month, but the final version is being designed to operate for five years.
The current lone recipient is reported to be recuperating in intensive care at Paris’ Georges Pompidou European Hospital, where he is awake and carrying on conversations. “We are delighted with this first implant, although it is premature to draw conclusions given that a single implant has been performed and that we are in the early postoperative phase,” says Carmat CEO Marcello Conviti.
According to a Reuters report, although the Carmat is similar in size to a natural adult human heart, it’s is somewhat larger and almost three times as heavy – weighing in at approximately 900 grams (2 lb). It should therefore fit inside 86 percent of men, but only 20 percent of women. That said, the company has stated that a smaller model could be made in time.
In the meantime, it’s still a matter of making sure the self-regulating bioprosthetic actually works and prolongs the life of patients who are in the final stages of heart failure. Assuming the trials go well, the Carmat is expected to be available within the European Union by early 2015, priced at between 140,000 and 180,000 euros, which works out to $190,000 – $250,000 US.
See what I mean? From anti-aging to artificial organs, the war on death proceeds apace. Some will naturally wonder if that’s a war meant to be fought, or an inevitably worth mitigating. Good questions, and one’s which we can expect to address at length as the 21st century progresses…
The year of 2013 ended with a bang for the field of health technology. And in my haste to cover as many stories as I could before the year ended, there were some rather interesting news developments which I unfortunately overlooked. But with the New Year just beginning, there is still plenty of time to look back and acknowledge these developments, which will no doubt lead to more in 2014.
The first comes from the UK, where the ongoing fight against cancer has entered a new phase. For years, researchers have been developing various breathalyzer devices to help detect cancer in its early phases. And now, a team from the University of Huddersfield plans to introduce one such cancer-detecting breathalyser (known as the RTube) into pharmacies.
According to Dr Rachel Airley, the lead researcher of the Huddersfield team, these molecules – which consist of genes, proteins, fragments of cells, secretions and chemicals produced by the metabolism of living tissue with the disease – form a kind of chemical and biological signature. Using breath testing devices like the RTube, Dr Airley developed a project to define a lung cancer “biomarker signature” that is detectable in breath.
According to Dr Airley:
When you get certain chemicals in someone’s breath, that can be a sign that there is early malignancy. We are looking to be able to distinguish between patients with early lung cancer and patients who have maybe got bronchitis, emphysema or non-malignant smoking related disease… or who have maybe just got a cough.
The goal of the project is to validate the signature in a large number of patients to ensure it can reliably distinguish between lung cancer and non-cancerous lung disease. Dr. Airley told us that this will require tracking the progress of patients for up to five years to see if the disease develops and can be linked back to a signature picked up in the patient’s breath at the beginning of the project.
So far, the project has secured £105,000 (US$170,000) in funding from the SG Court Pharmacy Group with the University of Huddersfield providing matching funding. The SG also operates the chain of pharmacies in the South East of England where the initial trials of the breathalyzer technology will be carried out.
The researchers predict that people visiting their local pharmacy for medication or advice to help them quite smoking will be invited to take a quick test, with the goal of catching the disease before the patients start to experience symptoms. Once symptoms present themselves, the disease is usually at an advanced stage and it is often too late for effective treatment.
Dr Airley stresses that the trial is to test the feasibility of the pharmacy environment for such a test and to ensure the quality of the test samples obtained in this setting are good enough to pick up the signature:
There are 12,000 community pharmacies in Britain and there is a big move for them to get involved in primary diagnostics, because people visit their pharmacies not just when they are ill but when they are well. A pharmacy is a lot less scary than a doctor’s surgery.
Dr Airley also says her team is about to start collecting breath samples from healthy volunteers and patients with known disease as a reference point and hope to start the pharmacy trials within two years. If all goes well, she says it will be at least five years before the test is widely available.
The next comes from Germany, where researchers have created a test that may help doctors predict one of the most severe side effects of antidepressants: treatment-emergent suicidal ideation (TESI). The condition is estimated to affect between four and 14 percent of patients, who typically present symptoms of TESI in the first weeks of treatment or following dosage adjustments.
So far doctors haven’t been able to find the indicators that could predict which patients are more likely to develop TESI, and finding the right medication and testing for side-effects is often a matter of simple trial and error. But a new test based on research carried out by the Max Planck Institute of Psychiatry in Munich, Germany, could change all that.
The researchers carried out genome-wide association studies on 397 patients, aged 18 to 75, who were hospitalized for depression, but were not experiencing suicidal thoughts at the time they began treatment. During the study, a reported 8.1 percent of patients developed TESI, and 59 percent of those developed it within the first two weeks of treatment.
To arrive at a list of reliable predictors, the team genotyped the whole group and then compared patients who developed TESI with those who didn’t. Ultimately, they found a subset of 79 genetic variants associated with the risk group. They then conducted an independent analysis of a larger sample group of in-patients suffering from depression and found that 90 percent of the patients were shown to have these markers.
In short, this test has found that the most dangerous side-effect of antidepressant use is genetic in nature, and can therefore be predicted ahead of time. In addition, the research shed new light on the age of those affected by TESI. Prior to discovering that all age groups in the study were at risk, the assumption had been that under-25s were more at risk, leading to the FDA to begin issuing warnings by 2005.
According to some experts, this warning has had the effect of reducing the prescription of antidepressants when treating depression. In other words, patients who needed treatment were unable to get it, out of fear that it might make things worse. This situation could now be reversed that doctors can avail themselves of this new assessment tool based on the research.
The laboratory-developed test, featuring a DNA microarray (chip), is being launched immediately by US company Sundance Diagnostics, ahead of submission to the FDA for market clearance. As Sundance CEO Kim Bechthold said in a recent interview:
A DNA microarray is a small solid support, usually a membrane or glass slide, on which sequences of DNA are fixed in an orderly arrangement. It is used for rapid surveys of the presence of many genes simultaneously, as the sequences contained on a single microarray can number in the thousands.
Ultimately, according to Bechthold, the aim here is to assist physicians in significantly reducing the risk of suicide in antidepressant use, and also to provide patients and families with valuable personal information to use with their doctors in weighing the risks and benefits of the medications.
Wow! From detecting cancer to preventing suicides, the New Year is looking bright indeed! Stay tuned for good news from the field of future medicine!
There’s just no shortage of breakthroughs in the field of biomedicine these days. Whether it’s 3D bioprinting, bionics, nanotechnology or mind-controlled prosthetics, every passing week seems to bring more in the way of amazing developments. And given the rate of progress, its likely going to be just a few years before mortality itself will be considered a treatable condition.
Philip Dydysnki, Chief of Radiology at Kosair Children’s Hospital, decided to approach the school when he and his medical team were looking at ways of treating Roland Lian Cung Bawi, a boy born with four heart defects. Using images taken from a CT scan, researchers from the school’s Rapid Prototyping Center were able to create and print a 3D model of Roland’s heart that was 1.5 times its actual size.
The device comprises a sensor inserted under the skin that relays hormone level data to a monitoring device, which in turn sends the information wirelessly to an app on the user’s smartphone. Based on the data, which is provided every five minutes, the app calculates required dosages of insulin or glucagon and communicates the information to two hormone infusion pumps worn by the patient.
The upcoming studies will allow the device to be tested by participants in real-world scenarios with decreasing amounts of supervision. The first will test the device’s performance for five continuous days involving twenty adults with type 1 diabetes. The results will then be compared to a corresponding five-day period during which time the participants will be at home under their own care and without the device.
Should the transitional trials be successful, a more developed version of the bionic pancreas, based on results and feedback from the previous trials, will be put through trials in 2015. If all goes well, Prof. Damiano hopes that the bionic pancreas will gain FDA approval and be rolled out by 2017, when his son, who has type 1 diabetes, is expected to start higher education.
Stories by Williams 