News From Space: 3-D Printed Spacecraft

3D_spaceprinting13D-Printing has led to many breakthroughs in the manufacturing industry in recent years. From its humble beginnings assembling models out of ABS plastic, the technology has been growing by leaps and bounds, with everything from construction and food printing to bioprinting becoming available. And as it happens, another major application is being developed by a private company that wants to bring the technology into orbit.

It’s called SpiderFab, a system of technologies that incorporates 3-D printing and robotic assembly to create  “on-orbit” structures and spaceship components (such as apertures, solar arrays, and shrouds). Developed by tech firm Tethers Unlimited, Inc. (TUI), the project is now in its second phase and recently landed a $500,000 development contract from NASA.

spiderfabOne of the greatest challenges of space exploration is the fact that all the technology must first be manufactured on Earth and then shuttled into orbit aboard a rocket or a shroud. The heavier the cargo, the larger the rocket needs to be. Hence, any major undertaking is likely to have a massive price tag attached to it. But by relocating the manufacturing process to a place on-site, aka. in orbit, the entire process will be much cheaper.

Towards this end, the SpiderFab, incorporates two major innovations in terms of transportation and manufacture. The first makes it possible to pack and launch raw materials, like spools of printable polymer, in a cost-effective way using smaller rockets. The second uses patented robotic fabrication systems that will process that material and aggregate it into structural arrangements.

3D_spaceprintingDr. Rob Hoyt, CEO of TUI, had this to say of his company’s brainchild in a recent interview with Co.Design:

SpiderFab is certainly an unconventional approach to creating space systems, and it will enable significant improvements for a wide range of missions.

The unorthodox system is also a solution to the problem that Hoyt began working on two decades ago when he first began working with NASA. While there, he experimented with on-orbit fabrication as a concept, but was limited due to the fact that there were no means available to make it reality. However, once 3-D printing became mainstream, he seized the opportunity presented. As he explains:

I didn’t strike on anything dramatically better than [previous investigations] until about six years ago, when additive manufacturing was really starting to take off. I realized that those techniques could be evolved to enable some dramatic improvements in what we can build in space.

spiderfab3At present, TUI is working on several different models of what the SpiderFab will eventually look like. The first of these is known as the Trusselator, one of many building blocks that will form the factory responsible for producing spacecraft components. The Trusselator is designed to print high-performance truss elements, while another, the Spinneret, will use 3-D printing-like techniques to connect and fuse together clusters of trusses.

Hoyt says that the TUI team will be further testing these processes in the next couple of months, first in the lab and then in a thermal-vacuum chamber. He hopes, however, that they will be able to conduct an on-orbit demonstration of SpiderFab a few years down the line. And with any luck, and more funding, NASA and other agencies may just convert their production process over to orbital 3-D printing facilities.

Alongside concepts like the SpaceX Grasshopper reusable rocket and reusable space craft, 3-D space printing is yet another revolutionary idea that is likely to bring the astronomical (no pun!) costs of space exploration down considerably. With affordability will come growth; and with growth, greater exploration will follow…

Star-Trek-universe

Sources: fastcodesign.com, tethers.com

Ending World Hunger: Insect-Based “Power Flour”

insect_flourIt has long been understood that if we, as a species, are going to deal with overpopulation and hunger, we need take a serious look at our current methods of food production. Not only are a good many of our practices unsustainable – monoculture, ranching, and overuse of chemical fertilizers being foremost amongst them – it is fast becoming clear that alternatives exist that are more environmentally friendly and more nutritious.

However, embracing a lot of these alternatives means rethinking our attitudes to what constitutes food. All told, there are millions of available sources of protein and carbohydrates that aren’t being considered simply because they seem unappetizing or unconventional. Luckily, researchers are working hard to find ways to tackle this problem and utilize these new sources of nutrition.

HULT-PRIZE-large570One such group is a team of McGill University MBA students who started the Aspire Food Group, an organization that will produce nutritious insect-based food products that will be accessible year-round to some of the world’s poorest city dwellers. Recently, this group won the $1 million Hult Prize for the development of an insect-infused flour that offers all the benefits of red meat – high protein and iron – but at a fraction of the cost.

The team – which consists of Mohammed Ashour, Shobhita Soor, Jesse Pearlstein, Zev Thompson and Gabe Mott – were presented with the social entrepreneurship award and $1 million in seed capital back in late September. The presentation was made by former U.S. president Bill Clinton in New York City at the Clinton Global Initiative’s annual meeting.

world_hungerThe Hult Prize Foundation runs an annual contest open to teams of four or five students from colleges and universities from around the world. Their task is to develop ideas for social enterprises – organizations that use market-based strategies to tackle social or environmental problems. This year’s challenge, selected by Clinton, was to tackle world hunger.

Over 10,000 students entered, and the McGill team was one of six which reached the final stage, where they pitched their idea Monday to judges that included Clinton, Nobel Peace Prize laureate Muhammad Yunus and Erathrin Cousin, CEO of the World Food Program. The $1 million was provided by the family of the Swedish billionaire Bertil Hult, who made his fortune with the venerable EF Education First company.

insect_flour1Mohammed Ashour explained the process behind the insect flour in an interview to CBC News:

We are farming insects and we’re grinding them into a fine powder and then we’re mixing it with locally appropriate flour to create what we call power flour. It is essentially flour that is fortified with protein and iron obtained from locally appropriate insects.

What is especially noteworthy about the product, aside from its sustainability, is the fact that it delivers plenty of protein and iron in an inexpensive package. These nutrients, the team noted, are in short supply in the diets of many people in developing nations, but can be found in high amounts in insects. For example, they note, crickets have a higher protein content per weight than beef.

???????????????????????????????And while the idea of eating insects might seem unappealing to many people living in the developed world, Soor pointed out that people in many of the countries they are targeting already eat insects. In addition, the type of insect used to produce the flour for a local market would be chosen based on local culinary preferences. As she put it:

There really isn’t a ‘yuck’ factor. For example, in Mexico, we’d go with the grasshopper. In Ghana, we’d go with the palm weevil.

The insects would also be mixed with the most common type of local flour, whether it be made from corn, cassava, wheat or something else. Thus, the product would not only provide nutrition, but would be locally sourced to ensure that it is accessible and beneficial to the local market.

Developed-and-developing-countriesIn addition, the team has already held taste tests in some markets. In one test, they offered people tortillas made from regular corn flour, corn flour containing 10 per cent cricket flour and corn flour containing 30 per cent cricket flour. As Ashour indicated, the reviews were met with approval:

Amazingly enough, we got raving reviews for the latter two… so it turns out that people either find it to be tasting neutral or even better than products that are made with traditional corn flour.

The team hopes to use the prize money to help them expand the reach of their organization to the over 20 million people living in urban slums around the world by 2018. And I can easily foresee how flours like this one could become a viable item when teamed up with 3D food printers, tailoring edible products that meet our nutritional needs without putting undue strain on the local environment.

And be sure to enjoy this video of the McGill students and their prize-winning flour, courtesy of CBC news:


Source: cbc.ca

Papa Zulu’s Cover Selection…

zombies-city-and-the-crowdHey all! Its been a busy season thus far, and after many months of slow progress, the editing process for Papa Zulu is just about over. Which means its time for me to start picking out cover designs! Recently, I tinkered with the write-up and then added some of the more recent reviews (these would be the five star ones I’ve been going on and one about lately!). Here’s how it reads:

“Men rise from one ambition to another: first, they seek to secure themselves against attack, and then they attack others.”

–Niccolo Machiavelli

In the barren deserts of New Mexico, the war against the Whiskey Delta continues. After years of fighting, the “Mage” and his Rattlesnakes have managed to get the upper hand on the undead, while back at their base, “Doc” Ross Cooper and his team are getting close to producing a vaccine from the Patient Zero strain. But things quickly change when a new opponent enters the arena. Ever since their encounter with rogue forces in LA, the Mage has worried that there are military forces back East, people who owe allegiance to another master and want the Patient Zero strain for themselves…

Praise for Whiskey Delta:
“This was an excellent book from start to finish.” -K.C. Williams

“Great story about soldiers doing solider business.” -John

“This was an absolutely fantastic read. Highly recommend for any fan of the zombie genre.” -Britanny

“This is a badass Zombie book.” -Kellie H.

“I could not put Whiskey Delta down till the end.” – W.M. Morgan

“This book is for all those zombie fans out there!” -The Pragmatic Procrastinator

As for the design itself, I’m a little torn between two contenders. For awhile now, I’ve been working with one that boasts olive borders, orange font, black background, and the photo of a soldier firing tracers into the night. That would be this one:

Pappa_Zulu2But recently I came upon another cool photo and began designing a new cover around it. Much like the other one, it’s an army stock photo, but this one shows a group of soldiers conducting live fire drills during the night. Using high-speed photo, it looks like an eye=popping laser show. Now here’s what that design looks like:

Pappa_Zulu3

What I also like about this one is the way the photo is watermarked into the background. The red tracers are really quite impressive, and the orange font still seems to work since there are traces of orange here too. But dangit if that black and olive pattern from the first one doesn’t still seem totally appropriate, not to mention the way the orange font and black background just blend with the photo!

So I’ve decided to crowdsource this one with a poll. Which shall it be? Cast your vote and help me determine what the sequel to Whiskey Delta is going to look like.

Winning Ideas: The Bodyheat Powered Flashlight!

body_heat_flashlightEvery year, IT giant Google holds an online competition open to students aged 13-18 from around the globe to come up with new and challenging scientific ideas. And this year, one the winners just happens to hail from my hometown of Victoria, British Columbia. Her name is Ann Makosinki, a 15 year old high school student who invented a way to power a flashlight using only the warmth of your hand.

She claimed a trophy made of Lego for the 15-16 age category at an awards gala that was held on Monday, Sept. 23rd. Her prizes were a $25,000 scholarship and a “once-in-a-lifetime experience” from either CERN (the European Organization for Nuclear Research), LEGO or Google. Quite the impressive accomplishment for a 11th grader, but then again, Makosinki has been a scientist at heart ever since she was a little kid.

google-science-fair-winners-2013For starters, when other children were playing with toy cars and dolls, she busied herself with transistors and microcircuits. What’s more, by Grade 6, she began submitting projects to science fairs and began showing an interest in alternative energy. Still, Makosinki was surprised to be getting an award, given her competition. As she said:

I’m in shock, I’m in shock. It’s actually kind of embarrassing because I didn’t even change [before the awards ceremony]. I didn’t even comb my hair or anything. I must have looked like an absolute mess on stage because I didn’t expect to go up at all.

As for the invention itself, it is easy to see why she won. Basically, it is an LED flashlight that relies on the thermoelectric effect to generate electricity when held. This is done through a series of devices that are known as Peltier tiles, which produce electricity when heated on one side and cooled on the other. The tiles are fixed to the outside of the flashlight while the tube itself is hollow.

peltier-figure-9When held one side of the Peltier tiles are heated by the warmth of the person’s hand, air flowing through the hollow tube helps keep the other side cool. This combination of body heat and air cooling allows enough power to be generated to maintain a steady beam of light for 20 minutes. And all without the need for batteries and the resulting ewaste when they go dead.

Makosinki came up with the idea while researching different forms of alternative energy a few years ago. Already, she had experimented with Peltier tiles for her Grade 7 science fair project. While researching her project, she thought of them again as a way to potentially capture the thermal energy produced by the human body. After doing some calculations, she found that the amount of energy produced by a person’s hand was theoretically sufficient to power an LED light.

ann_makosinksiHowever, putting it into practice proved somewhat more difficult. After buying some Peltier tiles on eBay, she tested them and found that while they generated more than enough power, the voltage produced was only a fraction of what she needed. She rectified this problem after doing some further research, where she discovered that the addition of transformers could be used to boost the voltage.

She spent months doing research on the internet, experimenting with different circuits and even building her own transformers, which still didn’t provide enough voltage. In the end, she came across an article on the web about energy harvesting that suggested an affordable circuit that would provide the voltage she needed when used with a recommended transformer. Finally, the circuit worked.

ann_makosinksi1Makosinski admitted there were points in the experiment when she thought it would never work. But as she said:

You just kind of have to keep going. This took quite awhile ’cause I had to do it during the school year as well and I had homework, plays, whatever that I was also doing.

After making it to the Google Science Fair, she and her colleagues spent the day presenting at Google’s headquarters in Mountain View, California. Here, the 15 judges – which included scientists from a variety of fields, science journalists, an astronaut, and a former Google Science Fair winner – witnessed their creations and tried to determine which held the most promise.

The other winners included Viney Kumar, an Australia student who captured the 13-14 age category for an Android app that warns drivers of an approaching emergency vehicle more than a minute in advance, in order to help clear a path for it. And then there was Elif Bilgin of Turkey, a 16-year old who took home the Scientific American Science in Action Prize and the Voter’s Choice Award for inventing a way to make plastic from banana peels.

Ann-Makosinski-Google-Science-Fair-2The Grand Prize for the 17-18 age category went to Eric Chen, a 17 year old student from San Diego who is researching a new kind of anti-flu medicine using a combination of computer modelling and biological studies. He received the top prize of a $50,000 scholarship and a 10-day trip to the Galapagos Islands.

Alas, Makosinki felt the best part of the competition was getting to meet the other finalists in person at last.

It’s just so inspiring to see other people who are kind of like me and kind of want to make a difference in the community not just by talking about it but by actually doing stuff.

What’s next for the young inventor? Personally, I hope Makosinki and her fellow prize winners will be forming their own research group and looking for new and exciting ways to come up with renewable energy, recycling, vaccinations, and electronics. What do you think Makonsinky, Kumar, Bilgin, Chen? That’s what Andraka and his fellow finalists did after winning ISEF 2012, and they seem to be doing pretty good. So… hintedy, hint hint!

And be sure to enjoy this video of Ann Makosinki showing off her invention, courtesy of Technexo:


Sources: cbc.ca, (2), gizmag.com, technexo.com, huffingtonpost.ca

Powered by the Sun: New Film Increases Solar Efficiency

sun_magneticfieldWith every passing year, solar power is getting cheaper and more efficient. And with every development that brings costs down and increases electrical yields, the day that it comes to replace fossil fuels and coal as the primary means of meeting our power needs gets that much closer. And with this latest development, this changeover may be coming sooner than expected.

It comes from North Carolina State University where researchers have developed a new system for strengthening the connections between stacked solar cells which could allow cells to operate at concentrations of up to 70,000 suns while minimizing wasted energy. This is especially good news seeing as how stacked cells are already an improvement over conventional solar cells.solar_panelStacked solar cells are made up of several cells that are placed one on top of the other, an arrangement that allows up to 45 percent of the absorbed solar energy to be converted into electricity. This is a significant improvement over single-junction solar cells which have a theoretical maximum conversion rate of 33.7 percent, and is made possible by the fact a stack formation prevents heat from being lost between panels.

The team at NCSU discovered that by inserting a very thin film layer of gallium arsenide into the connecting junction of stacked cells, they can eliminate energy loss ever further. The idea was inspired by the fact that cells typically start to break down at the connection junctions once they reach concentrations of 700 suns. With the addition of gallium arsenide in these spots, the connections become stronger, and all without sacrificing absorption.

solar_cell1Dr. Salah Bedair, a professor of electrical engineering at NCSU and senior author of the paper on this research:

Now we have created a connecting junction that loses almost no voltage, even when the stacked solar cell is exposed to 70,000 suns of solar energy. And that is more than sufficient for practical purposes, since concentrating lenses are unlikely to create more than 4,000 or 5,000 suns worth of energy.

At the moment, this technology is geared towards large scale solar power operations. Stacked cells are usually used in conjunction with optical concentration devices, such as Fresnel lenses, and mounted on a dual-axis solar trackers that keep the cell facing the Sun’s rays during daylight. So basically, we’re not likely to be seeing this technology available for local use. But it would be surprising if domestic consumers weren’t likely to benefit from it all the same.

solar_cell_galliumAs Dr. Bedair explained, the adoption of the technology will mean lower costs for the energy industry, and smaller arrays which will mean less land that needs to be set aside for use:

This [system] should reduce overall costs for the energy industry because, rather than creating large, expensive solar cells, you can use much smaller cells that produce just as much electricity by absorbing intensified solar energy from concentrating lenses. And concentrating lenses are relatively inexpensive.

What’s more, gallium arsenide is not exactly cheap to produce at the time. However, with constant refinements being made in industrial production processes, we can expect the cost of these to come down as well. As with everything else with solar power and renewable energy, its only a matter of time…

Source: gizmag.com

A Kinder, Gentler Internet: Youtube Algorithm Screens Comments

youtube_commentsThere’s scarcely a soul among us who hasn’t watched a video on YouTube. But have you ever stuck around long enough to read the comments section? It’s like a leper colony for the mind, a vindication for misanthropes everywhere. And after many years of being at the forefront of rudeness, racism, and generalized dumbassery, the YouTube comment section is getting a clean up.

Whereas the old system worked by placing the latest comments at the top nearest the video, regardless of their relevance or lack of redeeming content. The new system will employ a series of algorithms to determine what each viewer will find most relevant. This includes comments from your friends, from the video creator, and from “popular personalities” (i.e. celebs of one type or another).

youtube_convoBut it doesn’t stop there. Currently, since comments are displayed as they come in, making the act of following a conversation difficult at best. But from now on, the site will feature threaded conversations, which is consistent with Google policy, the site’s now owners. As for private conversations, the new platform will be powered by Google+, allowing users the option of deciding who they want their posts and videos to be visible to.

Additionally, there will be a sort of cross-posting between YouTube and Google+. If you post a YouTube video on Google+ and some one comments on it there, the comment will show up on the video over at YouTube, too. Alternatively, they could choose to have their comment only show up on YouTube, or only show up on Google+. There’s a lot more control.

googleplus-conversation

But perhaps most importantly of all, there are new filters that will be in place. As it stands, YouTube commenters enjoy total anonymity, which allows them to post racist, sexist, homophobic and vitriolic comments without fear. And while content creators can choose to allow all or no comments, or manually approve each comment, this is completely impractical for videos that garner millions of views a week.

But now, YouTube is introducing filters that will make it easier. The new filters basically allow content creators to not only be able to assign people to an Approved list or a Blocked list (which will auto-approve or auto-reject comments, respectively), they will be able to add keywords to a Blacklist. This will flag comments that contain those words and send them into a special list which can be reviewed and approved/rejected later.

ConversationPrism_2880x1800The threaded comments feature and began to be put into effect a little over a week ago. Filters were made available at the same time for channel pages only, but in the months to come they’ll become available for every individual video, giving content creators and commenters more control over the conversations they participate in. Basically, it will still be YouTube, but with some Facebook-like privacy and content filters.

And while many might deplore these new rules as an example of heavy handed “internet censorship”, there are many more who believe this change is overdue in coming. And given that the control rests with the users, who have the ability to share or be private, and to filter specific kinds of content, the basic spirit of a democratic, open forum remains.

Source: gizmodo.com

The Future is Here: Self-Healing Polymer

t1000I’ve heard of biomimetics – machinery and synthetics that can imitate organic materials – but this really takes the cake! In an effort to pioneer components and devices that would posses the regenerative powers of skin, a Spanish researcher Ibon Odriozola – who works for the CIDETEC Centre for Electrochemical Technologies in Spain – has created a polymer that could lead to a future where repairing machinery is as easy as suturing an open wound.

Comprised of a poly (urea-urethane) elastomeric matrix, the material is basically a network of complex molecular interactions that will spontaneously cross-link to “heal” most any break. In this context, the word “spontaneous” means that the material needs no outside intervention to begin its healing process, no catalyst or extra reactant.

healing-polymer-headerTo experiment with the material, Odriozola cut a sample in half with a razor blade at room temperature. And in just two hours, the cut healed itself with 97% efficiency. The reaction, called a metathesis reaction, has led Odriozola to dub the material his “Terminator” polymer, in reference to you-know-who (pictured above). Though the transition process takes a little longer, and involves polymers instead of metal, the basic principle is the same.

Unlike other self-healing materials, this one requires no catalyst and no layering. In addition to being very impressive to behold, this technology can extend the life spans of plastics that are under regular stress.  The group’s main goal now is to make a harder version, perhaps one that could be formed into such parts itself. As it exists today, the polymer is squishy and somewhat soft.

???????????In addition, a good self-healing material like this is a boon for ongoing efforts to find a viable material for artificial skin. Self-healing technology could also open the door to growth materials, as new units of the matrix could be incorporated as the material stretches and tears on the microscopic level. This would be especially useful when it comes to artificial skin, since it could grow over time and remove the need for replacement.

And if the healing mechanism proves strong enough, it could even be used as an adhesive or a sealant in other materials and even electronics. Just think of it! Everything from windows, to personal devices, to joints that are in need of padding. A simple injection of this type of material, and the breaks and aches go away. And given the progress being made with androids and life-like robots, its use as a source for artificial skin could go a long way to making them anthropomorphic.

And as usual, there’s a cool demonstration video. Enjoy!


Source: extremetech.com

News From Space: The Weird Atmospheres of Titan and Io

alien-worldStudying the known universe is always interesting, mainly because you never know what you’re going to find. And just when you think you’ve got something figured out – like a moon in orbit around one of the Solar Systems more distant planet’s – you learn that it can still find ways to surprise you. And interestingly enough, a few surprises have occurred back to back in recent weeks which are making scientists rethink their assumptions about these moons.

The first came from Io, Jupiter’s innermost moon and the most volcanically active body in the Solar System. All told, the surface has over 400 volcanic regions, roughly 100 mountains – some of which are taller than Mount Everest – and extensive lava flows and floodplains of liquid rock that pass between them. All of this has lead to the formation of Io’s atmosphere, which is basically a thin layer of toxic fumes.

Io_mapGiven its distance from Earth, it has been difficult to get a good reading on what the atmosphere is made up of. However, scientists believe that it is primarily composed of sulfur dioxide (SO2), with smaller concentrations of sulfur monoxide (SO), sodium chloride (NaCl), and atomic sulfur and oxygen. Various models predict other molecules as well, but which have not been observed yet.

However, recently a team of astronomers from institutions across the US, France, and Sweden, set out to better constrain Io’s atmosphere. Back in September they detected the second-most abundant isotope of sulfur (34-S) and tentatively detected potassium chloride (KCl). Expected, but undetected, were molecules like potassium chloride (KCl), silicone monoxide (SiO), disulfur monoxide (S2O), and other isotopes of sulfur.

Io_surfaceBut more impressive was the team’s tentative of potassium chloride (KCl), which is believed to be part of the plasma torus that Io projects around Jupiter. For some time now, astronomers and scientists have been postulating that Io’s volcanic eruptions produce this ring of plasma, which includes molecular potassium. By detecting this, the international team effectively found the “missing link” between Io and this feature of Saturn.

Another find was the team’s detection of the sulfur 34-S, an isotope which had previously never been observed.  Sulfur 32-S had been detected before, but the ratio between the 34-S and 32-S was twice that of what scientists believed was possible in the Solar System. A fraction this high has only been reported once before in a distant quasar – which was in fact an early galaxy consisting of an intensely luminous core powered by a huge black hole.

These observations were made using the Atacama Pathfinder Experiment (APEX) antenna – a radio telescope located in northern Chile. This dish is a prototype antenna for the Atacama Large Millimeter Array (ALMA). And while Io is certainly an extreme example, it will likely help terrestrial scientists characterize volcanism in general – providing a better understanding of it here on Earth as well as outside the Solar System.

TitanThe second big discovery was announced just yesterday, and comes from NASA’s Cassini space probe. In its latest find investigating Saturn’s largest moon, Cassini made the first off-world detection of the molecule known as propelyne. This simple organic compound is a byproduct of oil refining and fossil fuel extraction, and is one of the most important starting molecules in the production of plastics.

The molecules were detected while Cassini used its infrared spectrometer to stare into the hydrocarbon haze that is Titan’s atmosphere. The discovery wasn’t too surprising, as Titan is full of many different types of hydrocarbons including methane and propane. But spotting propylene has thus far eluded scientists. What’s more, this is the first time that the molecule has been spotted anywhere outside of Earth.

titan_cassiniThese finding highlight the alien chemistry of Saturn’s giant moon. Titan has moisture and an atmosphere, much like our own, except that its rains are made of hydrocarbons and its seas composed of ethane. Scientists have long wanted to explore this world with a boat-like rover, but given the current budget environment, that’s a distant prospect. Still, sales of propylene on Earth are estimated at $90 billion annually.

While no one is going to be mounting a collection mission to Titan anytime soon, it does offer some possibilities for future missions. These include colonization, where atmospheric propylene could be used to compose settlements made of plastic. And when it comes to terraforming, knowing the exact chemical makeup of the atmosphere will go a long way towards finding a way to make it breathable and warm.

And in the meantime, be sure to enjoy this video about Cassini’s latest discovery. With the government shutdown in effect, NASA’s resources remain offline. So we should consider ourselves lucky that the news broke before today and hope like hell they get things up and running again soon!


Sources: universetoday.com, wired.com

Coming Soon: A Universal Flu Vaccine?

flu_vaccineScientists have been making great strides in coming up with treatments and cures for illnesses that were previously thought to be incurable. While some of these are aimed at eliminating pandemics that have taken millions of lives worldwide (such as HIV/AIDS) others are aimed at treating the more common – but no less infectious – viruses, like the common flu.

When it comes to the latter, the difficulty is not so much in creating a cure, as it is a cure all. The flu is a virus that is constantly evolving, changing with the seasons and with each host. This requires medical researchers to constantly develop new vaccines year after year to address the latest strain, as well as specialized vaccines to address different  types – i.e. H1N1, swine, avian bird.

flu_vaccine1Luckily, a research team at Imperial College London say they have made a “blueprint” for a universal flu vaccine. Their report appeared in a recent issue of Nature Medicine. In their report, they specified that the key to creating a universal vaccine lies in targeting the core of the virus, rather than its ever-evolving DNA.

Just last year, researchers at the Friedrich-Loeffler Institute in Riems Island, Germany sought to create a similar vaccine that would target the virus’ RNA structure rather than the key proteins found in the DNA. By contrast, the Imperial researchers set about looking into T-cells, the crucial part of the immune system that is thought to be able to recognize proteins in the core.

2009_world_subdivisions_flu_pandemicTheir research began with a series of clinical examinations of the 2009 swine flu pandemic, which was produced by the combining of earlier strains of pig and bird flu. The team then compared levels of one kind of T-cells at the start of the pandemic with symptoms of flu in 342 staff and students at the university. They showed that the higher the levels of the T-cells a patient had, the milder their symptoms were.

Researchers then teased out the specific part of the immune system that offered some pandemic flu protection and which part of the virus it was attacking. from there, They began developing a vaccine that would trigger the production of these cells – known as CD8 T cells. These cells would attack the invading flu virus, ignoring the outer protein structure and focusing on the core which it had encountered before.

Influenza_virus_2008765Prof Ajit Lalvani, who led the study, told the BBC:

It’s a blueprint for a vaccine. We know the exact subgroup of the immune system and we’ve identified the key fragments in the internal core of the virus. These should be included in a vaccine. In truth, in this case it is about five years [away from a vaccine]. We have the know-how, we know what needs to be in the vaccine and we can just get on and do it.

The benefits of such a vaccine would be profound and obvious. While many of us consider the seasonal flu to be an inconvenience, it is important to note that it kills between 250,000 and 500,000 people worldwide each year. While this is a fraction of the total number of deaths attributed to AIDS (1.6 to 1.9 million in 2010, it is still a significant toll. What’s more, new pandemics have the potential to take doctors by surprise and kill large numbers of people.
t-cellHowever, the Imperial College researchers admit that it is generally harder to develop a T-cell vaccine than a traditional one designed to provoke an antibody response. The challenge will be to get a big enough of a T-cell response to offer protection and a response that will last. So while the blueprint is in place, medical researchers still have a long road ahead of them.

Prof John Oxford, of Queen Mary University of London, put it this way:

This sort of effect can’t be that powerful or we’d never have pandemics. It’s not going to solve all the problems of influenza, but could add to the range of vaccines. It’s going to be a long journey from this sort of paper to translating it into a vaccine that works.

AI-fightingfluWhat’s more, there are concerns that a T-cell vaccine would be limited when it comes to certain age groups. Jenner Institute at Oxford University, explains:

Live attenuated influenza vaccines which are given by nasal spray and will be used in children in the UK from this autumn are much better at increasing the number of influenza-specific T cells, but these vaccines only work in young children who haven’t yet had much exposure to influenza virus, so we need an alternative approach for adults.

Interestingly enough, this approach of stimulating the production of T-cells bears a striking resemblance to the work being done at the Vaccine and Gene Therapy Institute at OHSU, where researchers are working towards a vaccine that could also cure HIV. This research also appeared in Nature Medicine last month.

So not only could we be looking at a cure for both HIV and the flu in the near future, we could be looking at the containment of infectious viruses all over the world. As these two cases demonstrate, advances in medical science towards antivirals appear to be tied at the hip.

Sources: bbc.co.uk, gizmodo.com, nature.com