Of the many advances made by medical science in the past century, vaccinations are arguably the greatest. With the ability to inoculate people against infection, diseases like yellow fever, measles, rubella, mumps, typhoid, tetanus, polio, tuberculosis, and even the common flu have become controllable – if not eliminated. Nevertheless, medical researchers agree that there are still some things that can be improved upon when it comes to vaccinations.
Beyond the controversies surrounding a supposed link between vaccinations and autism, there is the simple fact that the current method of inoculating people is rather invasive. Basically, it requires people to sit through the rather uncomfortable process of being stuck with a needle, oftentimes in an uncomfortable place (like the shoulder). Luckily, many researchers are working on a way to immunize people using gentler methods.
At the University College Cork in Ireland, for example, scientists have just finished pre-clinical testing on an experimental malaria vaccine that is delivered through the skin. To deliver the vaccine into the body, the researchers used a skin patch with arrays of tiny silicon microneedles that painlessly create temporary pores. These pores provide an entry point for the vaccine to flow into the skin, as the patch dissolves and releases the drug.
To make the vaccine, the team used a live adenovirus similar to the virus that causes the common cold, but which they engineered to be safer and produce the same protein as the parasite that causes malaria. Adenoviruses are one of the most powerful vaccine platforms scientists have tested, and the one they used produced strong immunity responses to the malaria antigen with lower doses of the vaccine.
The research showed that the administration of the vaccine with the microneedle patch solves a shortcoming related to this type of vaccine, which is inducing immunity to the viral vector – that is, to the vaccine itself. By overcoming this obstacle, the logistics and costs of vaccination could be simpler and cheaper as it would not require boosters to be made with different strains. Besides, with no needles or pain involved, there’s bigger potential to reach more people requiring inoculation.
This is similar to the array used by researchers at King’s College in London, who are also developing a patch for possible HIV vaccine delivery. Researchers at University of Washington used a similar method last year to deliver the tuberculosis vaccine. The method is an improvement on this type of vaccine delivery since it is painless and non-invasive. It’s use is also being researched in relation to other infections, including Ebola and HIV.
The details of the research appeared in the journal Nature. Lead researcher, Dr. Anne Moore, is set to negotiate with Silicon Valley investors and technology companies to commercialize the vaccine.
At the closing ceremony of the AIDS 2014 conference a few weeks ago in Melbourne, Australia, many of the speakers – including longtime AIDS researcher and International AIDS Society Presidential Award winner Eric Goosby – told of how utterly terrifying the disease seemed 30 years ago. And while that fear is not gone, it has since diminished, replaced by and large with a sense of hope that the disease will be eradicated.
According to UNAIDS – the Joint United Nations Programme on HIV/AIDS, which is dedicated to destroying the disease by 2030 – the medical community has learned much in the past few years and stands a good chance at accomplishing this goal. And with new advances being announced every few months, hopes for a world in which this terrible disease no longer exists all seem firmly on track.
Consider this latest development, which comes from the Temple University School of Medicine in Philadelphia. Here, researchers have discovered how to permanently extricate HIV-1 from human cells, effectively curing a patient of the disease. Combined with new vaccines that have shown the ability to block infection (and in some cases, even reverse it), this news may yet be reason for even greater hope.
One of the main issues in the treatment of HIV-1 is not simply that it is expensive, but that antiretroviral therapy have terrible side effects that can speed up diseases more commonly associated with aging or can cause co-infections, such as Hepatitis C, to become worse. Added to this is that HIV is a tricky and tenacious disease that becomes part of a patient’s DNA, making it virtually impossible to eradicate.
However, researchers from Temple University School of Medicine have found a way to cut the infected genes out, potentially eradicating the virus for good and negating the need for lifelong ARV treatment. The technique uses a DNA-snipping enzyme, a nuclease, and a targeting RNA strand to hunt down the genome and cuts the HIV-1 DNA from it. The cell is able to repair its own genomes, essentially sewing itself together again, only now HIV-free.
This treatment will work in varied cell types such as the T-cells and monocytic cells that harbor HIV. In designing the molecular tools, researchers chose nucleotide sequences that do not appear in any coding sequences of human DNA to avoid what they call off-target effects, where patient’s cells or own DNA might be damaged. The technique may also be applicable against many other viruses.
There are still serious hurdles, like how to get the treatment into each, individual cell. Also, HIV-1 is known for mutations, and every patient has their own viral sequence. This means that there can be no single, prescriptive treatment for it. However, another potential upside is that there is the chance this may be used not simply as a treatment but also a vaccine as cells containing the nuclease-RNA combination do not acquire the HIV infection.
Dr. Kamel Khalili, Professor and Chair of the Department of Neuroscience at Temple, calls it an “important step” towards the eradication of AIDS, though it is still years away from the clinical stage. As he put it:
We want to eradicate every single copy of HIV-1 from the patient. That will cure AIDS. I think this technology is the way we can do it.
Though it is not the one-shot breakthrough many have been hoping for, this enzyme-based treatment is another step along the long road towards the end of HIV and another nail in its coffin. As long as treatments exist that are not only able to treat and block, but also fight the disease, there is much reason for hope.
And be sure to check out this video from Temple University, where Dr. Khalili explains the medical breakthrough:
Earlier this month, New York State governor Andrew Cuomo did something very meaningful and unexpected. In an effort to drastically cut the rate of new infections in the state, he announced that he was backing the development of Truvada – the controversial HIV prevention pill. The pill was officially endorsed by the CDC in May, but this is the first time that a high-level elected official has recommended its use.
Currently, about 3,000 new HIV infections are reported in New York state each year. Cuomo wants to reduce that to 750 by 2020, and to do so, he has introduced a three-pronged strategy. Parts one and two focus on more HIV tests and getting more people with HIV to see physicians. But the third part, which includes making Truvada readily available, has the potential to cause a stir since some believe that an HIV-prevention pill promotes lower rates of condom use.
Luckily, a recent scientific study conducted by the University of California at San Fransisco found no link between use of the drug and condom use. More importantly, the drug has a proven track record when it comes to preventing HIV. Recent reports state that it cuts infection rates by more than 90 percent, and people who take the drug every day are 99 percent protected from the onset of infection.
Furthermore, despite its $13,000-a-year price tag, the drug is covered by most insurers. So, its continued obscurity appears to have more to do with marketing than anything else. In truth, many people who are at risk for HIV still aren’t aware of the drug’s existence. And despite the CDC’s recent backing, its manufacturer, Gilead, has yet to market the drug for HIV prevention, even though it is currently used as part of treatment regimens.
This is why Cuomo’s announcement, which took place during Pride Weekend, was so important. By backing the drug formally, and encouraging physicians to get the word out, he is helping to promote awareness and curb HIV infection rates. Naturally, there are those who think Cuomo’s announcement is part of a ploy to get votes from members of the LGBTQ community.
Given the recent decline in condom use among teens of all sexual orientations, this is certainly good news. While a drug like this does nothing to prevent the acquisition of other STIs – such as gonorrhea or chlamydia – it is important to remember that these diseases are treatable and non-fatal. Ultimately, having an HIV prevention drug available will ensure that there is a preventive measure in place that people are more likely to use.
Beside the Truvada endorsement, the state is also set to start enforcing a 2010 law that requires doctors to regularly offer HIV testing to patients between the ages of 13 and 65. And the state recently repealed a law that asked doctors and nurses to obtain written consent from patients before performing HIV tests, because the requirement acted as a barrier to testing.
As a recent article in The New York Times points out, the most notable aspect of the state’s rejuvenated approach to combating HIV is the combined economics of the strategies involved. None of these methods should lead to increased spending because they don’t include new medical breakthroughs. Instead, the state will probably end up saving money since every prevented HIV case saves about $400,000 in medical costs.
And this is just one of many HIV preventions that has been proven safe, effective, and ready to market. Between bee-venom nanoparticle treatments, vaccines, and even topical creams that have been proven to eliminate the virus, the coming decades are likely to see a severe drop in the number of deaths associated with the disease. And by mid century, who knows? The disease that became the plague of the 20th century may finally be history!
With all of the world’s current problems, poverty, underdevelopment, terrorism, civil war, and environmental degradation, it’s easy to overlook how things are getting better around the world. Not only do we no longer live in a world where superpowers are no longer aiming nuclear missiles at each other and two-thirds of the human race live beneath totalitarian regimes; in terms of health, mortality, and income, life is getting better too.
So, in honor of the New Year and all our hopes for a better world, here’s a gander at how life is improving and is likely to continue…
1. Poverty is decreasing: The population currently whose income or consumption is below the poverty line – subsisting on less than $1.25 a day – is steadily dropping. In fact, the overall economic growth of the past 50 years has been proportionately greater than that experienced in the previous 500. Much of this is due not only to the growth taking place in China and India, but also Brazil, Russia, and Sub-Saharan Africa. In fact, while developing nations complain about debt crises and ongoing recession, the world’s poorest areas continue to grow.
2. Health is improving:
The overall caloric consumption of people around the world is increasing, meaning that world hunger is on the wane. Infant mortality, a major issue arising from poverty, and underdevelopment, and closely related to overpopulation, is also dropping. And while rates of cancer continue to rise, the rate of cancer mortality continue to decrease. And perhaps biggest of all, the world will be entering into 2014 with several working vaccines and even cures for HIV (of which I’ve made many posts).
3. Education is on the rise:
More children worldwide (especially girls) have educational opportunities, with enrollment increasing in both primary and secondary schools. Literacy is also on the rise, with the global rate reaching as high as 84% by 2012. At its current rate of growth, global rates of literacy have more than doubled since 1970, and the connections between literacy, economic development, and life expectancy are all well established.
4. The Internet and computing are getting faster:
Ever since the internet revolution began, connection speeds and bandwidth have been increasing significantly year after year. In fact, the global average connection speed for the first quarter of 2012 hit 2.6 Mbps, which is a 25 percent year-over-year gain, and a 14 percent gain over the fourth quarter of 2011. And by the second quarter of 2013, the overall global average peak connection speed reached 18.9 Mbps, which represented a 17 percent gan over 2012.
And while computing appears to be reaching a bottleneck, the overall increase in speed has increased by a factor of 260,000 in the past forty years, and storage capacity by a factor of 10,000 in the last twenty. And in terms of breaking the current limitations imposed by chip size and materials, developments in graphene, carbon nanotubes, and biochips are promising solutions.
5. Unintended pregnancies are down:
While it still remains high in the developing regions of the world, the global rate of unintended pregnancies has fallen dramatically in recent years. In fact, between 1995 and 2008, of 208 billion pregnancies surveyed in a total of 80 nations, 41 percent of the pregnancies were unintended. However, this represents a drop of 29 percent in the developed regions surveyed and a 20 percent drop in developing regions.
The consequences of unintended pregnancies for women and their families is well established, and any drop presents opportunities for greater health, safety, and freedom for women. What’s more, a drop in the rate of unwanted pregnancies is surefire sign of socioeconomic development and increasing opportunities for women and girls worldwide.
6. Population growth is slowing: On this blog of mine, I’m always ranting about how overpopulation is bad and going to get to get worse in the near future. But in truth, that is only part of the story. The upside is while the numbers keep going up, the rate of increase is going down. While global population is expected to rise to 9.3 billion by 2050 and 10.1 billion by 2100, this represents a serious slowing of growth.
If one were to compare these growth projections to what happened in the 20th century, where population rose from 1 billion to just over 6, they would see that the rate of growth has halved. What’s more, rates of population growth are expecting to begin falling in Asia by 2060 (one of the biggest contributors to world population in the 20th century), in Europe by 2055, and the Caribbean by 2065.
In fact, the only region where exponential population growth is expected to happen is Africa, where the population of over 1 billion is expected to reach 4 billion by the end of the 21st century. And given the current rate of economic growth, this could represent a positive development for the continent, which could see itself becoming the next powerhouse economy by the 2050s.
7. Clean energy is getting cheaper:
While the price of fossil fuels are going up around the world, forcing companies to turn to dirty means of oil and natural gas extraction, the price of solar energy has been dropping exponentially. In fact, the per capita cost of this renewable source of energy ($ per watt) has dropped from a high of $80 in 1977 to 0.74 this past year. This represents a 108 fold decrease in the space of 36 years.
And while solar currently comprises only a quarter of a percent of the planet’s electricity supply, its total share grew by 86% last year. In addition, wind farms already provide 2% of the world’s electricity, and their capacity is doubling every three years. At this rate of increase, solar, wind and other renewables are likely to completely offset coal, oil and gas in the near future.
Summary:
In short, things are looking up, even if they do have a long way to go. And a lot of what is expected to make the world a better place is likely to happen this year. Who knows which diseases we will find cures for? Who knows what inspirational leaders will come forward? And who knows what new and exciting inventions will be created, ones which offer creative and innovative solutions to our current problems?
Who knows? All I can say is that I am eager to find out!
The new year is literally right around the corner, folks. And I thought what better way to celebrate 2013 than by acknowledging its many scientific breakthroughs. And there were so many to be had – ranging in fields from bioresearch and medicine, space and extra-terrestrial exploration, computing and robotics, and biology and anthropology – that I couldn’t possibly do them all justice.
Luckily, I have found a lovely, condensed list which managed to capture what are arguably the biggest hits of the year. Many of these were ones I managed to write about as they were happening, and many were not. But that’s what’s good about retrospectives, they make us take account of things we missed and what we might like to catch up on. And of course, I threw in a few stories that weren’t included, but which I felt belonged.
So without further ado, here are the top 12 biggest breakthroughs of 2013:
1. Voyager 1 Leaves the Solar System:
For 36 years, NASA’s Voyager 1 spacecraft has travelling father and farther away from Earth, often at speeds approaching 18 km (11 miles) per second. At a pace like that, scientists knew Voyager would sooner or later breach the fringe of the heliosphere that surrounds and defines our solar neighborhood and enter the bosom of our Milky Way Galaxy. But when it would finally break that threshold was a question no one could answer. And after months of uncertainty, NASA finally announced in September that the space probe had done it. As Don Gurnett, lead author of the paper announcing Voyager’s departure put it: “Voyager 1 is the first human-made object to make it into interstellar space… we’re actually out there.”
2. The Milky Way is Filled with Habitable Exoplanets:
After years of planet hunting, scientists were able to determine from all the data gathered by the Kepler space probe that there could be as many as 2 billion potentially habitable exoplanets in our galaxy. This is the equivalent of roughly 22% of the Milky Way Galaxy, with the nearest being just 12 light years away (Tau Ceti). The astronomers’ results, which were published in October of 2013, showed that roughly one in five sunlike stars harbor Earth-size planets orbiting in their habitable zones, much higher than previously thought.
3. First Brain to Brain Interface:
In February of 2013, scientists announced that they had successfully established an electronic link between the brains of two rats. Even when the animals were separated by thousands of kms distance, signals from the mind of one could help the second solve basic puzzles in real time. By July, a connection was made between the minds of a human and a rat. And by August, two researchers at the Washington University in St. Louis were able to demonstrate that signals could be transmitted between two human brains, effectively making brain-to-brain interfacing (BBI), and not just brain computer interfacing (BCI) truly possible.
4.Long-Lost Continent Discovered:
In February of this year, geologists from the University of Oslo reported that a small precambrian continent known as Mauritia had been found. At one time, this continent resided between Madagascar and India, but was then pushed beneath the ocean by a multi-million-year breakup spurred by tectonic rifts and a yawning sea-floor. But now, volcanic activity has driven the remnants of the long-lost continent right through to the Earth’s surface.
Not only is this an incredibly rare find, the arrival of this continent to the surface has given geologists a chance to study lava sands and minerals which are millions and even billions of years old. In addition to the volcanic lava sands, the majority of which are around 9 million years old, the Oslo team also found deposits of zircon xenocryst that were anywhere from 660 million to 1.97 billion years old. Studies of these and the land mass will help us learn more about Earth’s deep past.
5. Cure for HIV Found!:
For decades, medical researchers and scientists have been looking to create a vaccine that could prevent one from being infected with HIV. But in 2013, they not developed several vaccines that demonstrated this ability, but went a step further and found several potential cures. The first bit of news came in March, when researchers at Caltech demonstrated using HIV antibodies and an approach known as Vectored ImmunoProphylaxis (VIP) that it was possible to block the virus.
Then came the SAV001 vaccine from the Schulich School of Medicine & Dentistry at Western University in London, Ontario, which aced clinical trials. This was punctuated by researchers at the University of Illinois’, who in May used the “Blue Waters” supercomputer to developed a new series of computer models to get at the heart of the virus.
But even more impressive was the range of potential cures that were developed. The first came in March, where researchers at the Washington University School of Medicine in St. Louis that a solution of bee venom and nanoparticles was capable of killing off the virus, but leaving surrounding tissue unharmed. The second came in the same month, when doctors from Johns Hopkins University Medical School were able to cure a child of HIV thanks to the very early use of antiretroviral therapy (ART).
And in September, two major developments occurred. The first came from Rutgers New Jersey Medical School, where researchers showed that an antiviral foot cream called Ciclopirox was capable of eradicating infectious HIV when applied to cell cultures of the virus. The second came from the Vaccine and Gene Therapy Institute at the Oregon Health and Science University (OHSU), where researchers developed a vaccine that was also able to cure HIV in about 50% of test subjects. Taken together, these developments may signal the beginning of the end of the HIV pandemic.
6. Newly Discovered Skulls Alter Thoughts on Human Evolution:
The discovery of an incredibly well-preserved skull from Dmanisi, Georgia has made anthropologists rethink human evolution. This 1.8 million-year old skull has basically suggested that our evolutionary tree may have fewer branches than previously thought. Compared with other skulls discovered nearby, it suggests that the earliest known members of the Homo genus (H. habilis, H.rudolfensis and H. erectus) may not have been distinct, coexisting species, but instead were part of a single, evolving lineage that eventually gave rise to modern humans.
7. Curiosity Confirms Signs of Life on Mars:
Over the past two years, the Curiosity and Opportunity rovers have provided a seemingly endless stream of scientific revelations. But in March of 2013, NASA scientists released perhaps the most compelling evidence to date that the Red Planet was once capable of harboring life. This consisted of drilling samples out of the sedimentary rock in a river bed in the area known as Yellowknife Bay.
Using its battery of onboard instruments, NASA scientists were able to detect some of the critical elements required for life – including sulfur, nitrogen, hydrogen, oxygen, phosphorus, and carbon. The rover is currently on a trek to its primary scientific target – a three-mile-high peak at the center of Gale Crater named Mount Sharp – where it will attempt to further reinforce its findings.
8. Scientists Turn Brain Matter Invisible:
Since its inception as a science, neuroanatomy – the study of the brain’s functions and makeup – has been hampered by the fact that the brain is composed of “grey matter”. For one, microscopes cannot look beyond a millimeter into biological matter before images in the viewfinder get blurry. And the common technique of “sectioning” – where a brain is frozen in liquid nitrogen and then sliced into thin sheets for analysis – results in tissue being deformed, connections being severed, and information being lost.
But a new technique, known as CLARITY, works by stripping away all of a tissue’s light-scattering lipids, while leaving all of its significant structures – i.e. neurons, synapses, proteins and DNA – intact and in place. Given that this solution will allow researchers to study samples of the brains without having to cut them up, it is already being hailed as one of the most important advances for neuroanatomy in decades.
9. Scientists Detect Neutrinos from Another Galaxy:
In April of this year, physicists working at the IceCube South Pole Observatory took part in an expedition which drilled a hole some 2.4 km (1.5 mile) hole deep into an Antarctic glacier. At the bottom of this hole, they managed to capture 28 neutrinos, a mysterious and extremely powerful subatomic particle that can pass straight through solid matter. But the real kicker was the fact that these particles likely originated from beyond our solar system – and possibly even our galaxy.
That was impressive in and off itself, but was made even more so when it was learned that these particular neutrinos are over a billion times more powerful than the ones originating from our sun. So whatever created them would have had to have been cataclysmicly powerful – such as a supernova explosion. This find, combined with the detection technique used to find them, has ushered in a new age of astronomy.
10. Human Cloning Becomes a Reality:
Ever since Dolly the sheep was cloned via somatic cell nuclear transfer, scientists have wondered if a similar technique could be used to produce human embryonic stem cells. And as of May, researchers at Oregon Health and Science University managed to do just that. This development is not only a step toward developing replacement tissue to treat diseases, but one that might also hasten the day when it will be possible to create cloned, human babies.
11. World’s First Lab Grown Meat:
In May of this year, after years of research and hundred of thousands of dollars invested, researchers at the University of Maastricht in the Netherlands created the world’s first in vitro burgers. The burgers were fashioned from stem cells taken from a cow’s neck which were placed in growth medium, grown into strips of muscle tissue, and then assembled into a burger. This development may prove to be a viable solution to world hunger, especially in the coming decades as the world’s population increases by several billion.
12. The Amplituhedron Discovered:
If 2012 will be remembered as the year that the Higgs Boson was finally discovered, 2013 will forever be remembered as the year of the Amplituhedron. After many decades of trying to reformulate quantum field theory to account for gravity, scientists at Harvard University discovered of a jewel-like geometric object that they believe will not only simplify quantum science, but forever alters our understanding of the universe.
This geometric shape, which is a representation of the coherent mathematical structure behind quantum field theory, has simplified scientists’ notions of the universe by postulating that space and time are not fundamental components of reality, but merely consequences of the”jewel’s” geometry. By removing locality and unitarity, this discovery may finally lead to an explanation as to how all the fundamental forces of the universe coexist.
These forces are weak nuclear forces, strong nuclear forces, electromagnetism and gravity. For decades, scientists have been forced to treat them according to separate principles – using Quantum Field Theory to explain the first three, and General Relativity to explain gravity. But now, a Grand Unifying Theory or Theory of Everything may actually be possible.
13. Bioprinting Explodes:
The year of 2013 was also a boon year for bioprinting – namely, using the technology of additive manufacturing to create samples of living tissue. This began in earnest in February, where a team of researchers at Heriot-Watt University in Scotland used a new printing technique to deposit live embryonic stem cells onto a surface in a specific pattern. Using this process, they were able to create entire cultures of tissue which could be morphed into specific types of tissue.
Later that month, researchers at Cornell University used a technique known as “high-fidelity tissue engineering” – which involved using artificial living cells deposited by a 3-D printer over shaped cow cartilage – to create a replacement human ear. This was followed some months later in April when a San Diego-based firm named Organova announced that they were able to create samples of liver cells using 3D printing technology.
And then in August, researchers at Huazhong University of Science and Technology were able to use the same technique create the world first, living kidneys. All of this is pointing the way towards a future where human body parts can be created simply by culturing cells from a donor’s DNA, and replacement organs can be synthetically created, revolutionizing medicine forever.
14. Bionic Machinery Expands:
If you’re a science buff, or someone who has had to go through life with a physical disability, 2013 was also a very big year for the field of bionic machinery. This consisted not only of machinery that could meld with the human body in order to perform fully-human tasks – thus restoring ambulatory ability to people dealing with disabling injuries or diseases – but also biomimetic machinery.
The first took place in February, where researchers from the University of of Tübingen unveiled the world’s first high-resolution, user-configurable bionic eye. Known officially as the “Alpha IMS retinal prosthesis”, the device helps to restore vision by converted light into electrical signals your retina and then transmitted to the brain via the optic nerve. This was followed in August by the Argus II “retinal prosthetic system” being approved by the FDA, after 20 years of research, for distribution in the US.
Later that same month, the Ecole Polytechnique Federale de Lausanne in Switzerland unveiled the world’s first sensory prosthetic hand. Whereas existing mind-controlled prosthetic devices used nerve signals from the user to control the movements of the limb, this new device sends electrostimulus to the user’s nerves to simulate the sensation of touch.
Then in April, the University of Georgia announced that it had created a brand of “smart skin” – a transparent, flexible film that uses 8000 touch-sensitive transistors – that is just as sensitive as the real thing. In July, researchers in Israel took this a step further, showing how a gold-polyester nanomaterial would be ideal as a material for artificial skin, since it experiences changes in conductivity as it is bent.
15. 400,000 Year-Old DNA Confuses Humanity’s Origin Story:
Another discovery made this year has forced anthropologist to rethink human evolution. This occurred in Spain early in December, where a team from the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany recovered a 400,000 year-old thigh bone. Initially thought to be a forerunner of the Neanderthal branch of hominids, it was later learned that it belonged to the little-understood branch of hominins known as Denisovans.
The discordant findings are leading anthropologists to reconsider the last several hundred thousand years of human evolution. In short, it indicates that there may yet be many extinct human populations that scientists have yet to discover. What’s more, there DNA may prove to be part of modern humans genetic makeup, as interbreeding is a possibility.
Scientists and researchers have been making great strides in the fight against HIV/AIDS in recent years. In addition to developing vaccines that have shown great promise, there have even been some treatments that have been shown to eliminate the virus altogether. And it seems that with this latest development, which was published in Nature earlier this month, there might be a treatment that can double as a cure.
Developed at the Vaccine and Gene Therapy Institute at the Oregon Health and Science University (OHSU), this new vaccine proved successful in about fifty percent of the clinical subjects that were tested, and may be able to cure patients who are currently on anti-retroviral drugs. If successful, this could mean that a preventative vaccine and cure could come in the same package, thus eliminating HIV altogether.
Currently, anti-retroviral drugs and HIV vaccine typically aim at improving the immune response of the patient in the long term. However, they are limited in that they can never completely clear the virus from the body. In fact, aside from a very few exceptional cases, researchers have long believed that HIV/AIDS could only be contained, but not completely cured.
The OHSU team, led by Dr. Louis Picker, has been working on its own vaccine for the past 10 years. In that time, their research has shown that an immune response can in fact go beyond containment and systematically wipe the virus out of the body. As with most early vaccine candidates, the study revolves around SIV – a more aggressive virus than HIV that can replicate up to 100 times faster and, unchecked, can cause AIDS in only two years.
Picker and his research team created the vaccine by working with cytomegalovirus (CMV), another virus which is itself persistent, but doesn’t cause disease. In their initial tests, the vaccine was found to generate an immunoresponse very similar to that generated by CMV, where T-cells that can search and destroy target cells were created and remained in the system, consistently targeting SIV-infected cells until the virus was cleared from the body.
For the sake of their clinical trials, simian subjects were used that were infected by the HIV virus. When treated with the team’s vaccine, half of the subjects initially showed signs of infection, but those signs gradually receded before disappearing completely. This sets it apart from other vaccines which also generate an immunoresponse, but one which fades over time.
According to Dr. Picker, it is the permanency of the T-cells that allows the immunoresponse to be consistent and slowly eradicate the virus, eventually eliminating it completely from the system. Says Dr. Picker of their trials and the possibilities for the vaccine:
The virus got in, it infected some cells, moved about in various parts of the body, but it was subsequently cleared, so that by two or three years later the monkeys looked like normal monkeys. There’s no evidence, even with the most sensitive tests, of the SIV virus still being there... We might be able to use this vaccine either to prevent infection or, potentially, even to apply it to individuals who are already infected and on anti-retroviral therapy. It may help to clear their infections so ultimately they can go off the drugs.
Currently, Picker and his the team are trying to understand why some of the vaccinated animals did not respond positively, in the hopes of further increasing the efficacy of the vaccine. Once these trials are complete, it could be just a hop, skip and a jump to getting FDA approval and making the vaccine/cure available to the open market.
Imagine, if you will, a world where HIV/AIDS is on the decline, and analysts begin predicting how long it will take before it is eradicated entirely. At this rate, such a world may be just a few years away. For those working in the field of medicine, and those of us who are around to witness it all, it’s an exciting time to be alive!
And be sure to enioy this video from OHSU where Dr. Picker speak about their vaccine and the efforts to end HIV:
The news that Caltech was developing a potential vaccine for HIV was considered one the biggest stories of 2012. And now, less than a year later, researchers at the Schulich School of Medicine & Dentistry at Western University in London, Ontario have announced that the vaccine not only passed its first round of clinical testing, but even boosted the production of antibodies in patients it was tested on.
The SAV001 vaccine is one of only a handful of HIV vaccines in the world, and is based on a genetically-modified ‘dead’ version of the virus. U.S. clinical testing began in the in March 2012, looking at HIV-infected men and women between the ages of 18 and 50. Half the target group was administered a placebo, while the other group was given SAV001. The first phase of trials wrapped up last month, with researchers optimistic about the vaccine’s future.
Dr. Chil-Yong Kang, a professor of microbiology and immunology and the head of the Western research team, explained the process in a recent interview with the Ontario Business Report:
We infect the cells with a genetically modified HIV-1. The infected cells produce lots of virus, which we collect, purify and inactivate so that the vaccine won’t cause AIDS in recipients, but will trigger immune responses.
This is the reverse of what researchers at Caltech did, who relied on a technique known as Vectored ImmunoProphylaxis (VIP) to stimulate antibody formation in lab mice. Here too, the researchers received immensely positive results. After introducing up 100 times the amount of HIV virus that what would be required to cause infection, the mice remained protected.
By demonstrating that not one, but two different methods of preventing the spread of HIV are effective, we could be looking at turning point in the war on HIV/AIDS. The only question is, when will a vaccine be commercially available? According to Sumagen, the South Korean biotech firm sponsoring the creation vaccine, manufacturing, as well as the USFDA requirements and other bureaucratic hurdles remain to contend with.
But, if all goes well with future trials, it could be commercially available in as little as five years. As CEO Jung-Gee Cho said in a press release:
We are now prepared to take the next steps towards Phase II and Phase III clinical trials. We are opening the gate to pharmaceutical companies, government, and charity organization for collaboration to be one step closer to the first commercialized HIV vaccine.
Paired with a possible cure which relies on nanoparticles and bee venom, we could even be looking at the beginning of the end of the pandemic, one which has caused between 25 and 30 million deaths worldwide since its discovery in 1981.
And in the meantime, check out this interview of Dr. Chil-Yong Kang as he explains how he and his research team developed their HIV vaccine, courtesy of the CHIR Canadian HIV Trial Network:
The future that is fast approaching us is one filled with possibilities, many of which were once thought to be the province of science fiction. Between tricorders and other new devices that can detect cancer sooner and at a fraction of the cost, HIV vaccines and cures, health monitoring tattoos and bionic limbs, we could be moving into an age where all known diseases are curable and physical handicaps will be non-existent.
And in the past few months, more stories have emerged with provide hope for millions of people living with diseases, injuries and disabilities. The first came just over three weeks ago from University of California, Berkley, where researchers have been working with an engineered virus which they claim could help cure blindness. As part of a gene therapy program, this treatment has been shown to effectively correct a rare form of inherited blindness.
For the past six years, medical science has been using adeno-associated viruses (AAV) as part of a gene therapy treatment to correct inherited retinal degenerative disease. However, the process has always been seen as invasive, since it involves injected the AAVs directly into a person’s retina with a needle. What’s more, the rpocess has shown itself to be limited, in that the injected virus does not reach all the retinal cells that need repair.
But as Professor David Schaffer, the lead researcher on the project, stated in an interview with Science Translational Medicine:
[D]octors have no choice because none of the gene delivery viruses can travel all the way through the back of the eye to reach the photoreceptors – the light sensitive cells that need the therapeutic gene.
Building on this and many more years of research, Prof David Schaffer and his colleagues developed a new process where they generated around 100 million variants of AAV and then selected five that were effective in penetrating the retina. They then used the best of these, a strain known as 7m8, to transport genes to cure two types of hereditary blindness on a group of mice.
In each case, the engineered virus delivered the corrective gene to all areas of the retina and restored retinal cells nearly to normal. But more importantly, the virus’ ability to penetrate the retina on its own makes the process far less invasive, and will likely be far more cost-effective when adapted to humans. And the process is apparently very convenient:
[W]e have now created a virus that you just inject into the liquid vitreous humor inside the eye and it delivers genes to a very difficult-to-reach population of delicate cells in a way that is surgically non-invasive and safe. It’s a 15-minute procedure, and you can likely go home that day.
Naturally, clinical trials are still needed, but the results are encouraging and Professor Schaffer indicated that his team are busy at work, now collaborating with physicians to identify the patients most likely to benefit from this gene-delivery technique.
Next up, there was the announcement back at the end of May that researchers from North Carolina State and University of North Carolina Chapel Hill had found yet another medical use for nanoparticles. In there case, this consisted of combating a major health concern, especially amongst young people today: diabetes.
In a study that was published in the Journal of Agricultural and Food Chemistry, the collaborating teams indicated that their solution of nanoparticles was able to monitor blood sugar levels in a group of mice and released insulin when their sugar levels got too high. Based on the results, the researchers claim that their method will also work for human beings with type 1 diabetes.
Each of the nanoparticles have a core of insulin that is contained with a degradable shell. When glucose levels in the blood reach high concentrations spike, the shell dissolves, releasing insulin and lowering the subject’s blood sugar. The degradable nano-network was shown to work in mice where a single injection kept blood glucose levels normal for a minimum of 10 days.
While the exact cause of this kind of diabetes is unknown, the effects certainly are. Patients living with this genetically-acquired form of the disease require several shots of insulin a day to keep their blood sugar levels under control. And even then, blindness, depression and even death can still result. What’s more, if the insulin shots are specifically calculated for the individual in question, side-effects can occur.
Hence the genius behind this new method. Not only would it relieve people who have type 1 diabetes from constantly injecting themselves, it would also remove the need to monitor their own blood sugar levels since the nanoparticles would be controlling them automatically.
In a study published recently in the Journal of Agricultural and Food Chemistry, Zhen Gu, lead author of the study claimed that the technology functions essentially the same as a pancreas. Hence another benefit of the new method, in that it could make pancreatic transplants – which are often necessary for patients with diabetes – unnecessary.
And last, but certainly not least, comes from the University of Illinois where John Rogers are developing a series of bio-absorbable electronic circuits that could help us win the war on drug-resistant bacteria. As part of a growing trend of biodegradable, flexible electronic circuits that operate wirelessly, fighting “superbugs” is just one application for this technology, but a very valuable one.
For some time now, bacteria that is resistant to antibiotics has been spreading, threatening to put the clock back 100 years to the time when routine, minor surgery was life-threatening. Some medical experts are warning that otherwise straightforward operations could soon become deadly unless new ways to fend off these infections are found. And though bacteria can evolve ways of evading chemical assaults, they are still vulnerable to direct assault.
This is how the new bio-absorbable circuits work: by heating up the virus. Each circuit is essentially a miniature electric heater that can be implanted into wounds and powered wirelessly to fry bacteria during healing before dissolving harmlessly into body fluids once their job is done. While this might sound dangerous, keep in mind that it takes only a relatively mild warming to kill bugs without causing discomfort or harm to surrounding tissues.
To fashion the circuits, Rogers and his colleagues used layers of utra-thin wafers and silk, material so thin that they disintegrate in water or body fluids or (in the case of silk) are known to dissolve anyway. For the metal parts, they used extra-thin films of magnesium, which is not only harmless but in fact an essential nutrient. For semiconductors, they used silicon membranes 300 nanometres thick, which also dissolve in water.
In addition to deterring bacteria, Rogers says that implantable, bio-absorbable RF electronics could be used to stimulate nerves for pain relief, and to stimulate bone re-growth, a process long proven to work when electrodes are placed on the skin or directly on the bone. Conceivably they could also be used to precisely control drug release from implanted reservoirs.
In other words, this is just the beginning. When it comes to the future of medicine, just about any barrier that was once considered impassable are suddenly looking quite porous…
The ongoing fight to end HIV has been a long and arduous one, but progress is being made. In addition to potential treatments being created that have shown promise, there are also efforts being mounted to understand how the virus works at an atomic level. This is great news, for as any practitioner of medicine will tell you, understanding a disease and knowing how to strike at the heart of it is the key to stopping it and making sure future generations don’t have to fear it.
In recent years, several major breakthroughs were announced for the treatment of HIV, treatments which many heralded as cures. In January of last year, the Danish Research Council awarded funding to a group of researchers who demonstrated that HIV could be “flushed” from infected cells where it tends to congregate and protect itself. Combined with vaccinations that turbocharge the body’s immune system, this method proved effective at eliminating the HIV virus in infected cells.
Another came back in November, when researchers at Caltech were even able to successfully spawn a significant amount of HIV antibodies in lab mice by using a new approach, known as Vectored ImmunoProphylaxis (VIP). An inversion of the traditional vaccination method, this new method produced plenty of HIV-preventing antibodies which they believed could be fashioned into a vaccine.
And finally, there were the experiments being conducted over at the Washington University School of Medicine, where researchers designed a solution that employed bee venom and a nanoparticle delivery system. Knowing that bee venom is capable of killing HIV, and that the virus is thousands of times smaller than your average cell, the solution proved quite effective at filtering out the virus and killing it while leaving surrounding tissue unharmed. Taken together, these two proposed solutions have left many thinking a cure is just around the corner.
Nevertheless, in order for this virus to truly be beaten, we need to understand it better. Hence why a group of scientists – using the University of Illinois’ “Blue Waters” supercomputer — have developed a new series of computer models that are finally giving researchers an atomic-level look at the formidable barrier mechanism enclosing the heart of the virus.
For example, its been known for some time that the HIV virus it’s covered in several layers of protective proteins. But beneath that outer shell resides a conical structure called the capsid, which houses the virus’ payload of genetic material. (See diagram below.) When HIV invades a cell, it’s the capsid that opens up to initiate the takeover process, allowing the virus to replicate inside the healthy host cell. Better understanding of how this mysterious delivery system operates could be one of the final steps to finding a cure.
And that’s where the modelling software really comes into play. How and when the HIV cell opens to deliver the capsid has long eluded researchers, and as Klaus Schulten, a physicist that was part of the team that modeled the virus, pointed out: “The timing of the opening of the capsid is essential for the degree of virulence of the virus.”
Using the Blue Waters, Schulten and his associates managed to map out the model all 64 million of the capsid’s atoms. Through countless simulations, they also discovered that the capsid’s microscopic outer casing is composed of 216 hexagon-shaped proteins that fit together in a honeycomb formation. These hexagonal structures are what give the capsid it’s tough outer shell and allow it to be such a harmful and insidious killer.
This painstakingly delicate process would have been unthinkable until just a few years ago, and represents the most complete picture of the HIV virus to date. What’s more, knowing what HIV looks like at the atomic level will help scientists to understand the timing of the virus’ delivery system. Since the opening of the virus’ protective layer is when it’s most vulnerable, Schulten and his colleagues hope to determine the precise timing of this event so a treatment can be developed that could attacks the virus at this exact moment.
Think of it as throwing a bomb into the mouth of a terrible war machine, right as it opens up its armored maw to bite you! Better yet, think of it as another step on the road to ending one of the greatest plagues humankind has ever had to deal with. Safety for the future, and justice for the victims!
Since it was first clinically observed in 1981, HIV/AIDS has been responsible for an estimated 25 million people worldwide. Since 2010, an estimated 34 million people were diagnosed with HIV, most of whom live within the developing world. In spite of anti-viral medicines which makes HIV manageable, countless people still die as a result of improper treatment or a lack of access.
As such, its little wonder then why medical researchers have been working for decades to find a cure. If it were possible to inoculate against the spread of HIV, the disease would all but disappear within a few generations. In addition, if it were possible to cure those already infected, and worldwide access were assured, HIV and AIDS could very well be eliminated in a decade or less.
Not too long ago, researchers at Caltech experimented with HIV antibodies which could very well lead to a vaccine in the near future. But even more exciting than this was the announcement from the Washington University School of Medicine in St. Louis earlier this month, where a research team demonstrated that nanoparticles infused with a toxic bee venom were capable of killing HIV. With this latest breakthrough, it seems that the days of one of the greatest plagues in history may truly be numbered.
The key to this discovery, which was made by Samuel A. Wickline and his team at the Washington University, involves what is known as cytolyic melittin peptides. Melittin is found in bee venom, and it has the fortuitous trait of being able to degrade the protective envelope that surrounds HIV. When delivered in both large and free concentrations, they observed that HIV was unable to withstand the assault and died.
Moreover, these melittin-loaded nanoparticles left the surrounding cells unharmed, which incidentally was no accident. The nanoparticles Wickline and his team developed were endowed with a kind of filter that prevents healthy cells from coming into contact with the toxin. But HIV, since its a viral strain, is small enough to sift right through these filters, thus exposing it to the toxin.
Currently, all known forms of HIV treatment involve preventing the virus from replicating to the point that it will morph into AIDS. By contrast, this new process targets the virus where it lives, focusing on killing on it rather than limiting its ability to reproduce. Adding to the general sense of excitement is speculation that this same concept could be used to combat other infectious STDs, including hepatitis B and C.
As a topical gel, suggestions are already circling that melittin-loaded nanoparticles could be combined with spermicidal cream to create the ultimate contraceptive that can also protect against STDs. Not only would this ensure truly safe sex, combined with melittin-treatment treatments for the infected and preventative vaccinations, it would also open up another front on the “war on HIV”.
My thanks to Rami for bringing this article to my attention. Since he pointed it out, its been making quite a few waves in the medical community and general public! Stories like these give me hope for the future…
Of the many advances made by medical science in the past century, vaccinations are arguably the greatest. With the ability to inoculate people against infection, diseases like yellow fever, measles, rubella, mumps, typhoid, tetanus, polio, tuberculosis, and even the common flu have become controllable – if not eliminated. Nevertheless, medical researchers agree that there are still some things that can be improved upon when it comes to vaccinations.
At the University College Cork in Ireland, for example, scientists have just finished pre-clinical testing on an experimental malaria vaccine that is delivered through the skin. To deliver the vaccine into the body, the researchers used a skin patch with arrays of tiny silicon microneedles that painlessly create temporary pores. These pores provide an entry point for the vaccine to flow into the skin, as the patch dissolves and releases the drug.
The research showed that the administration of the vaccine with the microneedle patch solves a shortcoming related to this type of vaccine, which is inducing immunity to the viral vector – that is, to the vaccine itself. By overcoming this obstacle, the logistics and costs of vaccination could be simpler and cheaper as it would not require boosters to be made with different strains. Besides, with no needles or pain involved, there’s bigger potential to reach more people requiring inoculation.
At the closing ceremony of the AIDS 2014 conference a few weeks ago in Melbourne, Australia, many of the speakers – including longtime AIDS researcher and International AIDS Society Presidential Award winner Eric Goosby – told of how utterly terrifying the disease seemed 30 years ago. And while that fear is not gone, it has since diminished, replaced by and large with a sense of hope that the disease will be eradicated.
However, researchers from Temple University School of Medicine have found a way to cut the infected genes out, potentially eradicating the virus for good and negating the need for lifelong ARV treatment. The technique uses a DNA-snipping enzyme, a nuclease, and a targeting RNA strand to hunt down the genome and cuts the HIV-1 DNA from it. The cell is able to repair its own genomes, essentially sewing itself together again, only now HIV-free.
Dr. Kamel Khalili, Professor and Chair of the Department of Neuroscience at Temple, calls it an “important step” towards the eradication of AIDS, though it is still years away from the clinical stage. As he put it:
Earlier this month, New York State governor Andrew Cuomo did something very meaningful and unexpected. In an effort to drastically cut the rate of new infections in the state, he announced that he was backing the development of Truvada – the controversial HIV prevention pill. The pill was officially endorsed by the CDC in May, but this is the first time that a high-level elected official has recommended its use.
This is why Cuomo’s announcement, which took place during Pride Weekend, was so important. By backing the drug formally, and encouraging physicians to get the word out, he is helping to promote awareness and curb HIV infection rates. Naturally, there are those who think Cuomo’s announcement is part of a ploy to get votes from members of the LGBTQ community.
And this is just one of many HIV preventions that has been proven safe, effective, and ready to market. Between 
Stories by Williams 