The Future of Medicine: Elastic Superglue and DNA Clamps

nanomachineryIf there’s one thing medical science is looking to achieve, it’s ways of dealing with sickness and injuries that are less invasive. And now more than ever, researchers are looking to the natural world for solutions. Whether it is working with the bodies own components to promote healing, or using technologies that imitate living organism, the future of medicine is all about engineered-natural solutions.

Consider the elastic glue developed by associate professor Jeffrey Karp, a Canadian-born medical researcher working at Harvard University. Created for heart surgery, this medical adhesive is designed to replace sutures and staples as the principle means of sealing incisions and defects in heart tissue. But the real kicker? The glue was inspired by sticky natural secretions of slugs.

hlaa-4Officially known as hydrophobic light-activated adhesive (HLAA), the glue was developed in a collaboration between Boston Children’s Hospital, MIT, and Harvard-affiliated Brigham and Women’s Hospital. And in addition to being biocompatible and biodegradable (a major plus in surgery), it’s both water-resistant and elastic, allowing it to stretch as a beating heart expands and contracts.

All of this adds up to a medical invention that is far more user-friendly than stitches and staples, does not have to be removed, and will not cause complications. On top of all that, it won’t complicate healing by restricting the heart’s movements, and only becomes active when an ultraviolet light shines on it, so surgeons can more accurately bind the adhesive exactly where needed.

hlaa-3The technology could potentially be applied not just to congenital heart defects, but to a wide variety of organs and other body parts. In an recent interview with CBC Radio’s Quirks & Quarks, Karp explained the advantages of the glue:

Sutures and staples really are not mechanically similar to the tissues in the body, so they can induce stress on the tissue over time. This is a material that’s made from glycerol and sebacic acid, both of which exist in the body and can be readily metabolized. What happens over time is that this material will degrade. Cells will invade into it and on top of it, and ideally the hole will remain closed and the patient won’t require further operations.

In lab tests, biodegradable patches coated with HLAA were applied to holes in the hearts of live pigs. Despite the high pressure of the blood flowing through the organs, the patches maintained a leakproof seal for the 24-hour test period. HLAA is now being commercially developed by Paris-based start-up Gecko Biomedical, which hopes to have it on the market within two to three years.

dnaclampIn another recent development, scientists at the Université de Montréal have created a new DNA clamp capable of detecting the genetic mutations responsible for causing cancers, hemophilia, sickle cell anemia and other diseases. This clamp is not only able to detect mutations more efficiently than existing techniques, it could lead to more advanced screening tests and more efficient DNA-based nanomachines for targeted drug delivery.

To catch diseases at their earliest stages, researchers have begun looking into creating quick screening tests for specific genetic mutations that pose the greatest risk of developing into life-threatening illnesses. When the nucleotide sequence that makes up a DNA strand is altered, it is understood to be a mutation, which specific types of cancers can be caused by.

DNA-MicroarrayTo detect this type of mutation and others, researchers typically use molecular beacons or probes, which are DNA sequences that become fluorescent on detecting mutations in DNA strands. The team of international researchers that developed the DNA clamp state that their diagnostic nano machine allows them to more accurately differentiate between mutant and non-mutant DNA.

According to the research team, the DNA clamp is designed to recognize complementary DNA target sequences, binds with them, and form a stable triple helix structure, while fluorescing at the same time. Being able to identify single point mutations more easily this way is expected to help doctors identify different types of cancer risks and inform patients about the specific cancers they are likely to develop.

dna_cancerDiagnosing cancer at a genetic level could potentially help arrest the disease, before it even develops properly. Alexis Vallée-Bélisle, a Chemistry Professor at the Université de Montréal, explained the long-term benefits of this breakthrough in a recent interview:

Cancer is a very complex disease that is caused by many factors. However, most of these factors are written in DNA. We only envisage identifying the cancers or potential of cancer. As our understanding of the effect of mutations in various cancer will progress, early diagnosis of many forms of cancer will become more and more possible.

Currently the team has only tested the probe on artificial DNA, and plans are in the works to undertake testing on human samples. But the team also believes that the DNA clamp will have nanotechnological applications, specifically in the development of machines that can do targeted drug-delivery.

dna_nanomachineFor instance, in the future, DNA-based nanomachines could be assembled using many different small DNA sequences to create a 3D structure (like a box). When it encounters a disease marker, the box could then open up and deliver the anti-cancer drug, enabling smart drug delivery. What’s more, this new DNA clamp could prove intrinsic in that assembly process.

Professor Francesco Ricci of the University of Rome, who collaborated on the project, explained the potential in a recent interview:

The clamp switches that we have designed and optimized can recognize a DNA sequence with high precision and high affinity. This means that our clamp switches can be used, for example, as super-glue to assemble these nano machines and create a better and more precise 3D structure that can, for example, open in the presence of a disease marker and release a drug.

Hmm, glues inspired by mollusc secretions, machines made from DNA. Medical technology is looking less like technology and more like biology every day now!

Sources: cbc.ca, gizmag.com, (2)

Cyberwars: NSA Building Quantum Computer

D-Wave's 128-qubit quantum processorAs documents that illustrate the NSA’s clandestine behavior continue to be leaked, the extents to which the agency has been going to gain supremacy over cyberspace are becoming ever more clear. Thanks to a new series of documents released by Snowden, it now seems that these efforts included two programs who’s purpose was to create a ““useful quantum computer” that would be capable of breaking all known forms of classical encryption.

According to the documents, which were published by The Washington Post earlier this month, there are at least two programs that deal with quantum computers and their use in breaking classical encryption — “Penetrating Hard Targets” and “Owning the Net.” The first program is funded to the tune of $79.7 million and includes efforts to build “a cryptologically useful quantum computer” that can:

sustain and enhance research operations at NSA/CSS Washington locations, including the Laboratory for Physical Sciences facility in College Park, MD.

nsa_aerialThe second program, Owning the Net, deals with developing new methods of intercepting communications, including the use of quantum computers to break encryption. Given the fact that quanutm machinery is considered the next great leap in computer science, offering unprecedented speed and the ability to conduct operations at many times the efficiency of normal computers, this should not come as a surprise.

Such a computer would give the NSA unprecedented access to encrypted files and communications, enadling them to break any protective cypher, access anyone’s data with ease, and mount cyber attacks with impunity. But a working model would also vital for defensive purposes. Much in the same way that the Cold War involved ongoing escalation between nuclear armament production, cybersecurity wars are also subject to constant one-upmanship.

quantum-computers-The-Next-GenerationIn short, if China, Russia, or some other potentially hostile power were to obtain a quantum computer before the US, all of its encrypted information would be laid bare. Under the circumstances, and given their mandate to protect the US’s infrastructure, data and people from harm, the NSA would much rather they come into possesion of one first. Hence why so much attention is dedicated to the issue, since whoever builds the worlds first quantum computer will enjoy full-court dominance for a time.

The mathematical, cryptographical, and quantum mechanical communities have long known that quantum computing should be able to crack classical encryption very easily. To crack RSA, the world’s prevailing cryptosystem, you need to be able to factor prime numbers — a task that is very difficult with a normal, classical-physics CPU, but might be very easy for a quantum computer. But of course, the emphasis is still very much on the word might, as no one has built a fully functioning multi-qubit quantum computer yet.

quantum-entanglement1As for when that might be, no one can say for sure. But the smart money is apparently anticipating one soon, since researchers are getting to the point where coherence on a single qubit-level is becoming feasible, allowing them to move on to the trickier subject of stringing multiple fully-entangled qubits together, as well as the necessary error checking/fault tolerance measures that go along with multi-qubit setups.

But from what it’s published so far, the Laboratory for Physical Sciences – which is carrying out the NSA’s quantum computing work under contract – doesn’t seem to be leading the pack in terms of building a quantum computer. In this respect, it’s IBM with its superconducting waveguide-cavity qubits that appears to be closer to realizing a quantum computer, with other major IT firms and their own supcomputer models not far behind.

hackers_securityDespite what this recent set of leaks demonstrates then, the public should take comfort in knowing that the NSA is not ahead of the rest of the industry. In reality, something like a working quantum computer would be so hugely significant that it would be impossible for the NSA to develop it internally and keep it a secret. And by the time the NSA does have a working quantum computer to intercept all of our encrypted data, they won’t be the only ones, which would ensure they lacked dominance in this field.

So really, thess latest leaks ought to not worry people too much, and instead should put the NSAs ongoing struggle to control cyberspace in perspective. One might go so far as to say that the NSA is trying to remain relevant in an age where they are becoming increasingly outmatched. With billions of terabytes traversing the globe on any given day and trillions of devices and sensors creating a “second skin” of information over the globe, no one organization is capable of controlling or monitoring it all.

So to those in the habit of dredging up 1984 every time they hear about the latest NSA and domestic surveillance scandal, I say: Suck on it, Big Brother!

Source: wired.com

The Internet of Everything

PrintAll of my recent interesting in the concept known as the “internet of things” has been turning up some interesting results. And it’s not hard to see why really, given all the research, innovation and commercial applications dedicated to making it a reality. And yet, a surprising amount of people seem to be in the dark about what this term means.

Again, not surprising, as high-tech trends tend to be somewhat esoteric, understood by only a select few at first and gradually trickling its way into public consciousness. To break it down, the Internet of Things is a concept where the real world will come to resemble the internet, where digital markers and wireless internet will make reality incredibly accessible and connected.

The-Internet-Of-Things-Smart-WorldThink of it this way: you wake up in the morning and receive instant updates from all of your household devices. You’re fridge tells you how close your food is to its expiration dates, and your thermostat sets itself based on the weather, season, and your habits. On your way to work, you are able to access emails and memos from your office server, and when you’re driving home, you are able to tell the house to warm up and turn the lights on.

All day long, you are able to monitor all of your gadgets and devices because they are all “tagged”, feeding you information on their locations and anything else you need to know in real-time. If you lose something, it alerts you to this fact and tells you where to find it. And if you’re out and about without your vehicle, you can summon it and get it to find its way to you.

InternetOfThings_1024x1448That’s the general idea, creating a “smart world” through the use of networking technology. Now here are some videos too that demonstrate the concept in action. All are from Cisco, the networking IT giant located in San Jose (capitol of Silicon Valley) and are promotional videos, basically showing what the company’s vision is and how they intend to bring it about.

“Circle Story”:
This video, perhaps more than anything, demonstrates how the world of the near future will be interconnected. As the name would suggest, it follows a day in the life of regular folks as they start their day, go to their various jobs, do their shopping, and how the entire process is all part of the same dance. And of course, Cisco showcases how its technology is helping to make it happen.

Curiously though, the people do look kind of bored, don’t they? Subtle social commentary, or were they just being realistic? You decide!


Barcelona Embraces IoE to Create a Smart City:
In this promotional video, we see how the city of Barcelona, Spain is using the concept of the Internet of Everything (IoE) to address the ongoing challenge of urbanization and growth. By embracing the latest in smart technology, Barcelona is becoming a shining example of what Cisco refers to as a “smart city”, much to the company’s delight!

What this consists of is Barcelona connecting its citizens, remote sensors, and all devices contained within to a city-wide WiFi. This in turn is offering people new services, facilitating energy-efficient reforms, and establishing new economic opportunities for the city’s companies and partners, not playing to the city’s reputation for social interaction and connectivity. Check out this video for the details:


The Road to the Internet of Everything:
Last, but not least, is Cisco’s promotional video of what the Internet of Everything is really all about. Intrinsic to the IoE is the fact that by 2020, the physical and digital world will be connected by 50 billion devices and 1 trillion sensors. Meanwhile, billions of electronic embedded devices will transmit terabytes of data, communicating everything from health information to updates at the speed of light.

The result of all this, according to the video, will be an “electronic skin” built on the internet, one which will overlay the world’s existing surface and communicate everything across its vast, virtual space. As we know, this skin is already being laid, but what is still to come is going to be pretty impressive and game-changing. The bottom line being that those that are in the know will be able to reap the benefits more quickly.


You may think these videos are little more than corporate promotion of company services. But if the “internet revolution” has taught us anything, it’s that the current range of technological change is here to stay, and is only going to be getting more pronounced as time goes on. And when it comes to predicting how these things will shape the world of tomorrow, those deeply involved in the development process are certainly worth listening to!

After all, they are helping to build that world, and are doing so because we’re letting them. Best to know what’s coming if you want to know how it’s going to effect you, and if you want to have anything to say about it, right?

Powered by the Sun: Efficiency Records and Future Trends

solar_panelThere have been many new developments in the field of solar technology lately, thanks to new waves of innovation and the ongoing drive to make the technology cheaper and more efficient. At the current rate of growth, solar power is predicted to become cheaper than natural gas by 2025. And with that, so many opportunities for clean energy and clean living will become available.

Though there are many contributing factors to this trend, much of the progress made of late is thanks to the discovery of graphene. This miracle material – which is ultra-thin, strong and light – has the ability to act as a super capacitor, battery, and an amazing superconductor. And its use in the manufacture of solar panels is leading to record breaking efficiency.

graphene-solarBack in 2012, researchers from the University of Florida reported a record efficiency of 8.6 percent for a prototype solar cell consisting of a wafer of silicon coated with a layer of graphene doped with trifluoromethanesulfonyl-amide (TFSA). And now, another team is claiming a new record efficiency of 15.6 percent for a graphene-based solar cell by ditching the silicon all together.

And while 15.6 efficiency might still lag behind certain designs of conventional solar cells (for instance, the Boeing Spectrolabs mass-production design of 2010 achieved upwards of 40 percent), this represents a exponential increase for graphene cells. The reason why it is favored in the production of cells is the fact that compared to silicon, it is far cheaper to produce.

solar_power2Despite the improvements made in manufacturing and installation, silicon is still expensive to process into cells. This new prototype, created by researchers from the Group of Photovoltaic and Optoelectronic Devices (DFO) – located at Spain’s Universitat Jaume I Castelló and the University of Oxford – uses a combination of titanium oxide and graphene as a charge collector and perovskite to absorb sunlight.

As well as the impressive solar efficiency, the team says the device is manufactured at low temperatures, with the several layers that go into making it being processed at under 150° C (302° F) using a solution-based deposition technique. This not only means lower potential production costs, but also makes it possible for the technology to be used on flexible plastics.

twin-creeks-hyperion-wafer-ii-flexibleWhat this means is a drop in costs all around, from production to installation, and the means to adapt the panel design to more surfaces. And considering the rate at which efficiency is being increased, it would not be rash to anticipate a range of graphene-based solar panels hitting the market in the near future – ones that can give conventional cells a run for their money!

However, another major stumbling block with solar power is weather, since it requires clear skies to be effective. For some time, the idea of getting the arrays into space has been proposed as a solution, which may finally be possible thanks to recent drops in the associated costs. In most cases, this consists or orbital arrays, but as noted late last year, there are more ambitious plans as well.

lunaring-3Take the Japanese company Shimizu and it’s proposed “Luna Ring” as an example. As noted earlier this month, Shimizu has proposed creating a solar array some 400 km (250 miles) wide and 11,000 km (6,800 miles) long that would beam solar energy directly to Earth. Being located on the Moon and wrapped around its entirety, this array would be able to take advantage of perennial exposure to sunlight.

Cables underneath the ring would gather power and transfer it to stations that facing Earth, which would then beam the energy our way using microwaves and lasers. Shimizu believes the scheme, which it showed off at a recent exhibition in Japan, would virtually solve our energy crisis, so we never have to think about fossil fuels again.

lunaring-2They predict that the entire array could be built and operational by 2035. Is that too soon to hope for planetary energy independence? And given the progress being made by companies like SpaceX and NASA in bringing the costs of getting into space down, and the way the Moon is factoring into multiple space agencies plans for the coming decades, I would anticipate that such a project is truly feasible, if still speculative.

Combined with increases being made in the fields of wind turbines, tidal harnesses, and other renewable energy sources – i.e. geothermal and piezoelectric – the future of clean energy, clear skies and clean living can’t get here soon enough! And be sure to check out this video of the Luna Ring, courtesy of the Shimizu corporation:


Sources:
gizmodo.com, fastcoexist.com

The Future of Flight: Morphing Wings

morphing-wingsSince the Wright Brothers developed the world’s first airplane, scientists and aerospace engineers have understood how important airflaps and wing design are to ensuring that a plane is able to achieve lift and land safely. During and after World War II, additional lessons were learned, where the sweep of a wing was found to be central to a plane achieving higher service ceilings and air speed velocities.

Since that time, many notable improvements have been made, but some strictures have remained the same. For example, conventional wings suffer from the problem of being fixed in a single position, which makes some aspects of performance possible but other things extremely difficult. In addition, flaps have remained virtually unchanged over the years, relying on hinged joints that are limited and vulnerable.

flexfoilIn both cases, the answer may lie in flexible and seamless materials, leading to wings that can change shape as needed. Such technology could not only enable better performance, but remove the need for hinges and gears. Towards this end, Michigan-based FlexSys has developed a way to optimize wing aerodynamics with FlexFoil, a seamless variable geometry airfoil system.

In development since 2001, FlexFoil is made from what is described only as “aerospace materials,” and is seamlessly integrated into the trailing edge of the wing. Based on a technology known as “distributed compliance,” the morphing structure integrates actuators and sensors that, according to Flexsys, results in “large deformations in shape morphing with very small strains.”

flexfoil1According to a 2006 paper co-written by mechanical engineer Dr. Sridhar Kota (the FlexFoil’s inventor), the foils are:

optimized to resist deflection under significant external aerodynamic loading and are just as stiff and strong as a conventional flap.

What this translates to in real terms is a tolerance of over 4500 kg (10,000 lbs) in air loads and the ability to distribute pressure more evenly throughout the wing, resulting in less strain in any one area. It is also said to reduce wind noise by up to 40 percent on landing, and to lessen build-up of both ice and debris. But the biggest benefit comes in terms of fuel economy.

flexfoil2When retrofitted onto a wing, FlexFoil can reduce fuel consumption by a claimed 4 to 8 percent, with that number climbing to 12 percent for those wings that are built are the system. What’s more, the technology could be applied to anything that moves relative to a fluid medium, including things like helicopter rotor blades, wind turbine blades, boat rudders, or pump impellers.

FlexFoil was officially introduced to the public this week at the AIAA (American Institute of Aeronautics and Astronautics) SciTech exposition in Washington, DC. Plans call for flight tests to be performed this July at NASA’s Dryden Flight Research Center, where the flaps of a Gulfstream business jet will be replaced with the foils.

Check out this video of the airwing design and what it does here:

morphing-wings1To be fair, this is not the only case of flexible, morphing aircraft in development right now. In fact, NASA has been looking to create a morphing aircraft concept ever since 2001. So far, this has included collaborating with Boeing and the U.S. Air Force to create the Active Aeroelastic Wing (AAW) which was fitted to the F/A-18 Hornet, a multirole combat jet in use with the USAF.

But looking long-term, NASA hopes to create a design for a morphing airplane (pictured above). Known as the 21st Century Aerospace Vehicle, and sometimes nicknamed the Morphing Airplane, the concept includes a variety of smart technologies that could enable inflight configuration changes for optimum flight characteristics, and is an example of biomimetic technology.

morphing-wings2In this case, the biological design being mimicked is that of a bird. Through the use of smart materials that are flexible and can change their shape on command, the 21st Century Aerospace Vehicle is able to shape its wings by extending the tips out and slightly upward to give it optimal lift capability. In this configuration, the inspiration for the aircraft’s wings is most clear (pictured above).

But once airborne, the aircraft needs a wing that is capable of producing less wind resistance while still maintaining lift. This is why the wings, upon reaching and service ceilings in excess of 3000 meters (10,000 feet), the wings then contract inward and sweep back to minimize drag and increase airspeed velocity.
Though this program has yet to bear fruit, it is an exciting proposal, and provides a glimpse of the future.

Be sure to check out NASA’s video of the CAV too, and keep your eyes on the skies. Chances are, jets that utilize smart, morphing surfaces are going to be there soon!


Sources:
gizmag.com
, flexsys.com, nasa.gov

Visions of the Future: Life in the 2030’s

future-city-1Gauging what life will be like down the road based on the emerging trends of today is something that scientists and speculative minds have been doing since the beginning of time. But given the rapid pace of change in the last century – and the way that it continues to accelerate – predicting future trends has become something of a virtual necessity today.

And the possibilities that are expected for the next generation are both awe-inspiring and cause for concern. On the one hand, several keen innovations are expected to become the norm in terms of transportation, education, health care and consumer trends. On the other, the growing problems of overpopulation, urbanization and Climate Change are likely to force some serious changes.

index-awards-horizontal-galleryHaving read through quite a bit of material lately that comes from design firms, laboratories, and grant funds that seek to award innovation, I decided to do a post that would take a look at how life is expected to change in the coming decades, based on what we are seeing at work today. So here we go, enjoy the ride, and remember to tip the driver!

Housing:
When it comes to designing the cities of the future – where roughly 5 of the worlds 8.25 billion people are going to live – meeting the basic needs of all these folks is complicated by the need to meet them in a sustainable way. Luckily, people all across the world are coming together to propose solutions to this problem, ranging from the small and crafty to the big and audacious.

wallsmart_paintConsider that buildings of the future could be coated with Smart Paint, a form of pigment that allows people to change the color of their domicile simply by pushing a button. Utilizing nano-particles that rearrange themselves to absorb a different part of the spectrum, the paint is able to reflect whatever wavelength of visible light the user desires, becoming that color and removing the need for new coats of paint.

And consider that apartments and houses in this day could be lighted by units that convert waste light energy from their light bulbs back into functional ambient light. This is the idea behind the Trap Light, a lamp that comes equipped with photoluminescent pigments embedded directly into the glass body. Through this process, 30 minutes of light from an incandescent or LED light bulb provides a few hours of ambient lighting.

trap_lightAnd in this kind of city, the use of space and resources has come to be very efficient, mainly because it has had to. In terms of low-rent housing, designs like the Warsaw-inspired Keret House are very popular, a narrow, 14-sqaure meter home that still manages to fit a bathroom, kitchen and bedroom. Being so narrow, city planners are able to squeeze these into the gaps between older buildings, its walls and floors snapping together like Lego.

When it comes to other, larger domiciles (like houses and apartment blocks), construction is likely to become a much more speedy and efficient process – relying on the tools of Computer-Assisted Design (CAD) and digital fabrication (aka. the D-process). Basically, the entire fabrication process is plotted in advance on computer, and then the pieces are tailor made in the factory and snapped together on site.


And lets not forget anti-gravity 3-D printing as a means of urban assembly, as proposed by architecture students from the Joris Laarman Lab in Amsterdam. Using quick-hardening materials and dispensed by robot-driven printers, entire apartment blocks – from electronic components to entire sections of wall – within a few days time. Speedier, safer and more efficient than traditional construction.

Within these buildings, water is recycled and treated, with grey water used to fertilize crops that are grown in house. Using all available spaces – dedicated green spaces, vertical agriculture, and “victory gardens” on balconies – residents are able to grow their own fruits and vegetables. And household 3-D food printers will dispense tailor-made treats, from protein-rich snacks and carb crackers to chocolate and cakes.

anti-grav3dAnd of course, with advances in smart home technology, you can expect that your appliances, thermostat, and display devices will all be predictive and able to anticipate your needs for the day. What’s more, they will all be networked and connected to you via a smartphone or some other such device, which by 2030, is likely to take the form of a smartwatch, smartring or smartbracelet.

Speaking of which…

Smart Devices and Appliances:
When it comes to living in the coming decades, the devices we use to manage our everyday lives and needs will have evolved somewhat. 3-D printing is likely to be an intrinsic part of this, manufacturing everything from food to consumer products. And when it comes to scanning things for the sake of printing them, generating goods on demand, handheld scanners are likely to become all the rage.

consumer_2030That’s where devices like the Mo.Mo. (pictured above) will come into play. According to Futurist Forum, this molecular scanning device scans objects around your house, tells you what materials they’re made from, and whether they can be re-created with a 3-D printer. Personal, household printers are also likely to be the norm, with subscriptions to open-source software sites leading to on-demand household manufacturing.

And, as already mentioned, everything in the home and workplace is likely to be connected to your person through a smart device or embedded chips. Consistent with the concept of the “Internet of Things”, all devices are likely to be able to communicate with you and let you know where they are in real time. To put that in perspective, imagine SIRI speaking to you in the form of your car keys, telling you they are under the couch.

future-officeTelepresence, teleconferencing and touchscreens made out of every surface are also likely to have a profound effect. When a person wakes in the morning, the mirror on the wall will have displays telling them the date, time, temperature, and any messages and emails they received during the night. When they are in the shower, the wall could comforting images while music plays. This video from Corning Glass illustrates quite well:


And the current range of tablets, phablets and smartphones are likely to be giving way to flexible, transparent, and ultralight/ultrathin handhelds and wearables that use projection and holographic technology. These will allow a person to type, watch video, or just interface with cyberspace using augmented reality instead of physical objects (like a mouse or keyboard).

And devices which can convert, changing from a smartphone to a tablet to a smartwatch (and maybe even glasses) are another predicted convenience. Relying on nanofabrication technology, Active-Matrix Organic Light-Emitting Diode (AMOLED) technology, and touch-sensitive surfaces, these devices are sure to corner the market of electronics. A good example is Nokia’s Morph concept, shown here:


Energy Needs:

In the cities of the near-future, how we generate electricity for all our household appliances, devices and possibly robots will be a going concern. And in keeping with the goal of sustainability, those needs are likely to be met by solar, wind, piezoelectric, geothermal and tidal power wherever possible. By 2030, buildings are even expected to have arrays built in to them to ensure that they can meet their own energy needs independently.

strawscaperThis could look a lot like the Strawscraper (picture above), where thousands of fronds utilize wind currents to generate electricity all day long; or fields filled with Windstalks – where standing carbon-fiber reinforced poles generate electricity by simply swaying with the wind. Wind farms, or wind tunnels and turbines (as envisioned with the Pertamina Energy Tower in Jakarta) could also be used by buildings to do the same job.

In addition, solar panels mounted on the exterior would convert daylight into energy. Assuming these buildings are situated in low-lying areas, superheated subterranean steam could easily be turned into sources of power through underground pipes connected to turbines. And for buildings located near the sea, turbines placed in the harbor could do the same job by capturing the energy of the tides.

asiancairns_pl14mFurthermore, piezoelectric devices could be used to turn everyday activity into electricity.  Take the Pavegen as an example, a material composed of recycled tires and piezoelectric motors that turns steps into energy. Equipping every hallway, stairwell and touch surface with tensile material and motors, just about everything residents do in a building could become a source of added power.

On top of that, piezoelectric systems could be embedded in roads and on and off ramps, turning automobile traffic into electrical power. In developed countries, this is likely to take the form of advanced materials that create electrical charges when compressed. But for developing nations, a simple system of air cushions and motors could also be effective, as demonstrated by Macías Hernández’ proposed system for Mexico City.

And this would seem like a good segue into the issue of…

Mass Transit:
future-city3According to UN surveys, roughly 60% of the world’s population will live in cities by the year 2030. Hopefully, the 5.1 billion of us negotiating tight urban spaces by then will have figured out a better way to get around. With so many people packed into dense urban environments, it is simply not practical for all these individuals to rely on smog-emitting automobiles.

For the most part, this can be tackled by the use of mass transit that is particularly fast and efficient, which are the very hallmarks of maglev trains. And while most current designs are already speedy and produce a smaller carbon footprint than armies of cars, next-generation designs like the Hyperloop, The Northeast Maglev (TNEM), and the Nagoya-Tokyo connector are even more impressive.

scmaglev-rendering-washington-stationDubbed by Elon Musk as the “fifth form” of transportation, these systems would rely on linear electric motors, solar panels, and air cushions to achieve speeds of up to 1290 kilometers per hour (800 mph). In short, they would be able to transport people from Los Angeles and San Francisco in 30 minutes, from New York to Washington D.C. in 60 minutes, and from Nagoya to Tokyo in just 41.

When it comes to highways, future designs are likely to take into account keeping electric cars charged over long distances. Consider the example that comes to us from Sweden, where Volvo is also working to create an electric highway that has embedded electrical lines that keep cars charged over long distances. And on top of that, highways in the future are likely to be “smart”.

electric-highwayFor example, the Netherlands-based Studio Roosegaarde has created a concept which relies on motion sensors to detect oncoming vehicles and light the way for them, then shuts down to reduce energy consumption. Lane markings will use glow-in-the-dark paint to minimize the need for lighting, and another temperature-sensitive paint will be used to show ice warnings when the surface is unusually cold.

In addition, the road markings are expected to have longer-term applications, such as being integrated into a robot vehicle’s intelligent monitoring systems. As automated systems and internal computers become more common, smart highways and smart cars are likely to become integrated through their shared systems, taking people from A to B with only minimal assistance from the driver.

smart-highwaysAnd then there’s the concept being used for the future of the Pearl River Delta. This 39,380 square-km (15,200 square-mile) area in southeastern China encompasses a network of rapidly booming cities like Shenzhen, which is one of the most densely populated areas in the world. It’s also one of the most polluted, thanks to the urban growth bringing with it tons of commuters, cars, and vehicle exhaust.

That’s why NODE Architecture & Urbanism – a Chinese design firm – has come up with a city plan for 2030 that plans put transportation below ground, freeing up a whole city above for more housing and public space. Yes, in addition to mass transit – like subways – even major highways will be relegated to the earth, with noxious fumes piped and tunneled elsewhere, leaving the cityscape far less polluted and safer to breathe.

Personal cars will not be gone, however. Which brings us to…

Personal Transit:
electric_carIn the future, the majority of transport is likely to still consist of automobiles, albeit ones that overwhelmingly rely on electric, hydrogen, biofuel or hybrid engines to get around. And keeping these vehicles fueled is going to be one of the more interesting aspects of future cities. For instance, electric cars will need to stay charged when in use in the city, and charge stations are not always available.

That’s where companies like HEVO Power come into play, with its concept of parking chargers that can offer top-ups for electric cars. Having teamed up with NYU Polytechnic Institute to study the possibility of charging parked vehicles on the street, they have devised a manhole c0ver-like device that can be installed in a parking space, hooked up to the city grid, and recharge batteries while commuters do their shopping.

chevy_envAnd when looking at individual vehicles, one cannot underestimate the role by played by robot cars. Already, many proposals are being made by companies like Google and Chevrolet for autonomous vehicles that people will be able to summon using their smartphone. In addition, the vehicles will use GPS navigation to automatically make their way to a destination and store locations in its memory for future use.

And then there’s the role that will be played by robotaxis and podcars, a concept which is already being put to work in Masdar Eco City in the United Arab Emirates, San Diego and (coming soon) the UK town of Milton Keynes. In the case of Masdar, the 2GetThere company has built a series of rails that can accommodate 25,000 people a month and are consistent with the city’s plans to create clean, self-sustaining options for transit.

Robotaxi_2getthereIn the case of San Diego, this consists of a network known as the Personal Rapid Transit System – a series of on-call, point to point transit cars which move about on main lines and intermediate stations to find the quickest route to a destination. In Britian, similar plans are being considered for the town of Milton Keynes – a system of 21 on-call podcars similar to what is currently being employed by Heathrow Airport.

But of course, not all future transportation needs will be solved by MagLev trains or armies of podcars. Some existing technologies – such as the bicycle – work pretty well, and just need to be augmented. Lightlane is a perfect example of this, a set of lasers and LED lights that bikers use to project their own personal bike lane from under the seat as they ride.

lightlaneAnd let’s not forget the Copenhagen Wheel, a device invented by MIT SENSEable City Lab back in 2009 to electrify the bicycle. Much like other powered-bicycle devices being unveiled today, this electric wheel has a power assist feature to aid the rider, a regenerative braking system that stores energy, and is controlled by sensors in the peddles and comes with smart features can be controlled via a smartphone app.

On top of all that, some research actually suggests that separating modes of transportation – bike lanes, car lanes, bus lanes, etc. – actually does more harm than good to the people using them. In Europe, the traffic concept known as “shared spaces” actually strips paths of traffic markings and lights, and allow walkers and drivers to negotiate their routes on their own.

transportation_tripanelShared spaces create more consideration and consciousness for other people using them, which is why the Boston architecture firm Höweler + Yoon designed the “Tripanel” as part of their larger vision for the Boston-Washington corridor (aka. “Boswash”). The Tripanel features a surface that switches among grass, asphalt, and photovoltaic cells, offering a route for pedestrians, bikers, and electric cars.

Education:
When it comes to schooling ourselves and our children, the near future is likely to see some serious changes, leading to a virtual reinventing of educational models. For some time now, educators have been predicting how the plurality of perspectives and the rise of a globalized mentality would cause the traditional mode of learning (i.e. centralized schools, transmission learning) to break down.

Classroom-of-the-Future01And according to other speculative thinkers, such as Salim Ismail – the director of Singularity University – education will cease being centralized at all and become an “on-demand service”. In this model, people will simply “pull down a module of learning”, and schooldays and classrooms will be replaced by self-directed lessons and “microlearning moments”.

In this new learning environment, teleconferencing, telepresence, and internet resources are likely to be the main driving force. And while the size and shape of future classrooms is difficult to predict, it is likely that classroom sizes will be smaller by 2030, with just a handful of students using portable devices and display glasses to access information while under the guidance of a teacher.

envisioning-the-future-of-educationAt the same time, classrooms are likely to be springing up everywhere, in the forms of learning annexes in apartment buildings, or home-school environments. Already, this is an option for distance education, where students and teachers are connected through the internet. With the addition of more sophisticated technology, and VR environments, students will be able to enter “virtual classrooms” and connect across vast distances.

According to Eze Vidra, the head of Google Entrepreneurs Europe: “School kids will learn from short bite-sized modules, and gamification practices will be incorporated in schools to incentivize children to progress on their own.” In short, education will become a self-directed, or (in the case of virtual environments) disembodied experienced that are less standardized, more fun, and more suited to individual needs.

Health:
medtechMany experts believe that medicine in the future is likely to shift away from addressing illness to prevention. Using thin, flexible, skin-mounted, embedded, and handheld sensors, people will be able to monitor their health on a daily basis, receiving up-to-date information on their blood pressure, cholesterol, kidney and liver values, and the likelihood that they might contract diseases in their lifetime.

All of these devices are likely to be bundled in one way or another, connected via smartphone or other such device to a person’s home computer or account. Or, as Ariel Schwatz of CoExist anticipates, they could come in the form of a “Bathroom GP”, where a series of devices like a Dr.Loo and Dr. Sink measure everything from kidney function to glucose levels during a routine trip.

doctor_bathroomBasically, these smart toilets and sinks screen for illnesses by examining your spittle, feces, urine and other bodily fluids, and then send that data to a microchip embedded inside you or on a wristband. This info is analyzed and compared to your DNA patterns and medical records to make sure everything is within the normal range. The chip also measures vital signs, and Dr Mirror displays all the results.

However, hospitals will still exist to deal with serious cases, such as injuries or the sudden onset of illnesses. But we can also expect them to be augmented thanks to the incorporation of new biotech, nanotech and bionic advances. With the development of bionic replacement limbs and mind-controlled prosthetics proceeding apace, every hospital in the future is likely to have a cybernetics or bioenhancement ward.

Prosthetic armWhat’s more, the invention of bioprinting, where 3-D printers are able to turn out replacement organic parts on demand, is also likely to seriously alter the field of medical science. If people are suffering from a failing heart, liver, kidney, or have ruined their knees or other joints, they can simply put in at the bioprinting lab and get some printed replacement parts prepared.

And as a final, encouraging point, diseases like cancer and HIV are likely to be entirely curable. With many vaccines that show the ability to not only block, but even kill, the HIV virus in production, this one-time epidemic is likely to be a thing of the past by 2030. And with a cure for cancer expected in coming years, people in 2030 are likely to view it the same way people view polio or tetanus today. In short, dangerous, but curable!

Buying/Selling:
future_money2When it comes to living in 2030, several trends are expected to contribute to people’s economic behavior. These include slow economic growth, collaborative consumption, 3-D printing, rising costs, resource scarcity, an aging population, and powerful emerging economies. Some of these trends are specific, but all of them will effect the behavior of future generations, mainly because the world of the future will be even more integrated.

As already noted, 3-D printers and scanners in the home are likely to have a profound effect on the consumer economy, mainly by giving rise to an on-demand manufacturing ethos. This, combined with online shopping, is likely to spell doom for the department store, a process that is already well underway in most developed nations (thanks to one-stop shopping).

sharing economy brandHowever, the emergence of the digital economy is also creating far more in the way of opportunities for micro-entrepreneurship and what is often referred to as the “sharing economy”. This represents a convergence between online reviews, online advertising of goods and services, and direct peer-to-peer buying and selling that circumvents major distributors.

This trend, which is not only reaching back in time to reestablish a bartering economy, but is also creating a “trust metric”, whereby companies, brand names, and even individuals are being measured by to their reputation, which in turn is based on their digital presence and what it says about them. Between a “sharing economy” and a “trust economy”, the economy of the future appears highly decentralized.

bitcoinFurther to this is the development of cryptocurrencies, a digital medium of exchange that relies solely on consumer demand to establish its value – not gold standards, speculators or centralized banks. The first such currency was Bitcoin, which emerged in 2009, but which has since been joined by numerous others like Litecoin, Namecoin, Peercoin, Ripple, Worldcoin, Dogecoin, and Primecoin.

In this especially, the world of 2030 is appearing to be a very fluid place, where wealth depends on spending habits and user faith alone, rather than the power of governments, financial organizations, or centralized bureaucracies. And with this movement into “democratic anarchy” underway, one can expect the social dynamics of nations and the world to change dramatically.

Space Travel!:
space_cameraThis last section is of such significance that it simply must end with an exclamation mark. And this is simply because by 2030, many missions and projects that will pave the way towards a renewed space age will be happening… or not. It all comes down to whether or not the funding is made available, public interest remains high, and the design and engineering concepts involved hold true.

However, other things are likely to become the norm, such as space tourism. Thanks to visionaries like World View and Richard Branson (the pioneer of space tourism with Virgin Galactic), trips to the lower atmosphere are likely to become a semi-regular occurrence, paving the way not only for off-world space tourism, but aerospace transit across the globe as well.

asteroid_neo_studyPrivate space exploration will also be in full-swing, thanks to companies like Google’s Space X and people like Elon Musk. This year, Space X is preparing for the first launch of it’s Falcon Heavy rocket, a move which will bring affordable space flight that much closer. And by 2030, affordability will be the hallmarks of private ventures into space, which will likely include asteroid mining and maybe the construction of space habitats.

2030 is also the year that NASA plans to send people to Mars, using the Orion Multi-Purpose Crew Vehicle and a redesigned Saturn V rocket. Once there, the crew will conduct surface studies and build upon the vast legacy of the Spirit, Opportunity and Curiosity Rovers to determine what Mars once looked like. This will surely be a media event, the likes of which has not been seen since the Moon Landing.

Mars_OneSpeaking of media events, by 2030, NASA may not even be the first space agency or organization to set foot on Mars. Not if Mars One, a nonprofit organization based in the Netherlands, get’s its way and manages to land a group of colonists there by 2023. And they are hardly alone, as Elon Musk has already expressed an interest in establishing a colony of 80,000 people on the Red Planet sometime in the future.

And Inspiration Mars, another non-profit organization hosted by space adventurist Dennis Tito, will have already sent an astronaut couple on a round-trip to Mars and back (again, if all goes as planned). The mission, which is currently slated for 2018 when the planets are in alignment, will therefore be a distant memory, but will serve as an example to all the private space ventures that will have followed.


In addition to Mars, one-way trips are likely to be taking place to other celestial bodies as well. For instance, Objective Europa – a non-profit made up of  scientists, conceptual artists, and social-media experts – plans to send a group of volunteers to the Jovian moon of Europa as well. And while 2030 seems a bit soon for a mission, it is likely that (if it hasn’t been scrapped) the program will be in the advanced stages by then.

NASA and other space agencies are also likely to be eying Europa at this time and perhaps even sending ships there to investigate the possibility of life beneath it’s icy surface. Relying on recent revelations about the planet’s ice sheet being thinnest at the equator, a lander or space penetrator is sure to find its way through the ice and determine once and for all if the warm waters below are home to native life forms.

europa-lander-2By 2030, NASA’s MAVEN and India’s MOM satellites will also have studied the Martian atmosphere, no doubt providing a much fuller picture of its disappearance. At the same time, NASA will have already towed an asteroid to within the Moon’s orbit to study it, and begun constructing an outpost at the L2 Lagrange Point on the far side of the Moon, should all go as planned.

And last, but certainly not least, by 2030, astronauts from NASA, the ESA, and possibly China are likely to be well on their way towards the creation of a permanent outpost on the Moon. Using a combination of 3-D printing, robots, and sintering technology, future waves of astronauts and settlers will have permanent domes made directly out of regolith with which to conduct research on the Lunar surface.

ESA_moonbaseAll of these adventures will help pave the way to a future where space tourism to other planets, habitation on the Moon and Mars, and ventures to the asteroid belt (which will solve humanity’s resource problem indefinitely), will all be the order of the day.

Summary:
To break it all down succinctly, the world of 2030 is likely to be rather different than the one we are living in right now. At the same time though, virtually all the developments that characterize it – growing populations, bigger cities, Climate Change, alternative fuels and energy, 3-D printing, cryptocurrencies, and digital devices and communications – are already apparent now.

Still, as these trends and technologies continue to expand and are distributed to more areas of the world – not to mention more people, as they come down in price – humanity is likely to start taking them for granted. The opportunities they open, and the dependency they create, will have a very deterministic effect on how people live and how the next generation will be shaped.

All in all, 2030 will be a  very interesting time because it will be here that so many developments – the greatest of which will be Climate Change and the accelerating pace of technological change – will be on the verge of reaching the tipping point. By 2050, both of these factors are likely to come to a head, taking humanity in entirely different directions and vying for control of our future.

Basically, as the natural environment reels from the effects of rising temperatures and an estimated CO2 concentration of 600 ppm in the upper atmosphere, the world will come to be characterized by famine, scarcity, shortages, and high mortality. At the same time, the accelerating pace of technology promises to lead to a new age where abundance, post-scarcity and post-mortality are the norm.

So in the end, 2030 will be a sort of curtain raiser for the halfway point of the 21st century, during which time, humanity’s fate will have become largely evident. I’m sure I’m not alone in hoping things turn out okay, because our children are surely expecting to have children of their own, and I know they would like to leave behind a world the latter could also live in!

Sources: fastcoexist.com, (2), (3), cnn.com, designtoimprovelife.dk, un.org

The Future is Here: The Wearable Landmine Detector

landmine1In certain developing nations, landmines are a terrible scourge that cause countless deaths and injuries. In most cases, the landmines are forgotten relics, the leftover remnants of civil wars, terrorist campaigns and national liberation efforts. Have been buried in unmarked areas and forgotten, many of the victims that come across these little packages of death do so entirely by accident.

Over the past century, the situation has become such that a ban was placed on their sale and in 1997 – officially known as the Anti-Personnel Mine Ban Convention or Ottawa Treaty (my old hometown, where the treaty was signed). However, banning the manufacture and sale of the devices addresses the problem at only one end, and does not address the many thousands of mines that have to be found and disposed of.

landmine_problemIn Colombia, for instance, some 10,000 have been maimed by anti-personnel devices since 1990, putting the country second only to Afghanistan in the total number of deaths and injuries associated with landmines. This is due to Colombia’s long guerrilla war, where groups like the Revolutionary Armed Forces of Colombia (FARC) have used mines to protect their bases and drug plantations.

The only real solution, of course, is to clear the mines and destroy them – a process that is now under way. In the meantime, however, people are still exposed to danger, and there’s a need for technology that helps people walk through rural areas without constant fear. Enter the SaveOneLife, a wearable landmine detector you slip into your shoe that may save your life.

saveonelifeDesigned by Lemur Studio, a design firm in Bogotá, the detector alerts the wearer if an explosive device is within a few feet of their path. It’s aimed at troops, people eradicating illicit crops (i.e. coca leaves and poppies), and farmers, all people who have to deal with landmines on a regular basis. Currently in the conceptual phase, the studio is looking for funding and support to get it built.

The detector consists of a coil printed on a thin conductive material that produces an electromagnetic field. This field in turn detects other electromagnetic fields that are emitted by large pieces metal nearby. If it finds a mine within the wearer’s proximity, the device sends a signal to a wristband, telling the wearer to watch out or change direction.

saveonelife2Iván Pérez, Lemur’s creative director, is currently presenting the idea to Colombia’s military, who he hopes will fund development. But of course, the device is intended for use far beyond the armed forces, ensuring that there are no more accidental victims. As Pérez himself explained:

The device was created with the goal of saving a life, hence the name, first by the families of the victims and second for the cost effects of military forces by the loss of his men in combat. We would like many people to benefit from it, not just people in the armed forces but also peasants and workers. We hope that some company or government wants to give us the support we need to complete the project and bring it to reality.

The idea has been nominated for several design prizes. And if funded, is likely to be adopted for use by NGOs, medics, engineers, civilians and military forces worldwide. But even if Pérez and his studio are not endorsed by the Colombian government (which is unlikely given the problem of landmines), an international crowdfunding campaign is likely to succeed.

landmine2After all, the problem of landmines is one that cuts across nations, organizations, and people of all walks of life, and a device that helps deal with this problem is likely to draw a lot of attention and interest. Being able to tackle the problem of forgotten ordinance and hidden dangers at the other end of the things will be a big step in helping to eliminating this dangerous legacy.

Source: fastcoexist.com

 

The Future is Here: Handheld 3-D Bioprinter

handheld_bioprinterSince it’s inception, bioprinting has offered medical science and astounding range of applications, with new being added every day. In just the past few years, researchers have found ways to create 3-D printed cartilage, replacement skin, and even miniature kidneys and livers using stem cells. And now, with this latest development, doctor’s may be able to “draw” replacement tissue as easily as they scrawl their signatures on a prescription pad.

It’s known as the BioPen, a handheld surgical device that works a little like a mini-3-D printer may soon be used to help repair damaged bones. Developed by Austrian researchers, the pen allows a surgeon to draw layers of stem cells directly at the site of an injury. Much like a a 3-D printer deposits plastic one layer at a time, the BioPen deposits gel in layers to create a 3-D structure.

BioPenAfter filling the damaged bone with the cells – mixed with a biodegradable seaweed extract to hold everything together- an ultraviolet light on the pen sets the gel in place. After the cells are in place, they multiply and eventually form functioning tissue. The device can also be used to apply growth factors to stimulate cell growth and other drugs (like cortisone) directly to where they are needed.

University of Wollongong professor Gordon Wallace, one of the researchers who is working on the project along with a team from the University of Melbourne, expressed the benefits of the device this way:

Biology works in 3-D. The ability to provide an appropriate structural environment for the stem cells enables more effective development into the appropriate tissue.

3dstemcellsIn the past, surgeons might have just injected stem cells to the desired area. But now, using the pen to build a small scaffold out of the gel, the cells can be better protected and more likely to survive. The researchers say it’s also easier to be precise with the pen in hand, and the whole process takes less time than surgeries would have in the past.

To further illustrate the uses and applications of additive manufacturing, the prototype itself was built in the researchers’ lab using a 3-D printer. According to Wallace, next-generation fabrication techniques not only made it possible to easily build the pen, but they also make it possible to quickly iterate new versions of the hardware.

bioprinted heartAnd while their partners at St. Vincent’s Hospital in Melbourne are working on optimizing the cell material, Wallace and his team of researchers will begin conducting animal trials with the BioPen, beginning later this year. If all goes well, the device could be undergoing human trials sometime in 2015, and available in hospitals in just a few years time.

And combined with other procedures that can generate replacement tissue (eyes, organs, skin), we will be looking at the age of biomedicine in full bloom!

Source: fastcoexist.com

Food From Space: NASA’s 3-D Pizza Printer (Cont’d)

3DpizzaLast Spring, NASA made headlines when it announced that its was granting a developer $125,000 to build a prototype 3-D food printer that would be able to create pizzas and other tasty food items. This is part of NASA’s larger effort to bring 3-D printing into space so that astronauts could meet their nutritional and supply needs on site.

And according to this most recent video, courtesy of Anjan Contractor, it seems that the project had begun to bear fruit. Contractor is the lead engineer behind the printer design, and was employed by NASA’s Systems & Materials Research Corporation to complete a printer that could provide astronauts a nutritious, comforting alternative to the canned and freeze-dried prepackaged foods they’re currently stuck with.

3-D_pizzaAs you can see from the video, the machine does a pretty good job of creating a rectangular, margherita pizza – albeit with some minor spillage. And, according to Contractor, the device takes about 70 seconds to cook the pizza after the printer nozzles were finished laying down the liquid crust-precursor, followed by the tomato sauce and liquid cheese.

If NASA decides it wants to move ahead with the printer, it will still be many, many years before astronauts are eating 3-D printed pizza and other such delectables in space. But this proof of concept is a major step in that direction, and NASA is likely to see its project through to completion before attempting any long-range missions (such as to Mars).

After all, astronauts being in space for extended periods of time is the very reason alternatives are being contemplated in the first place. And in the meantime, check out this video of Contractor’s printer as it generates a pizza:


Source: fastcoexist.com

Year-End Health News: Anti-Aging and Artificial Hearts

medtechHere we have two more stories from last year that I find I can’t move on without posting about them. And considering just how relevant they are to the field of biomedicine, there was no way I could let them go unheeded. Not only are developments such as these likely to save lives, they are also part of a much-anticipated era where mortality will be a nuisance rather than an inevitability.

The first story comes to us from the University of New South Wales (UNSW) in Australia and the Harvard Medical School, where a joint effort achieved a major step towards the dream of clinical immortality. In the course of experimenting on mice, the researchers managed to reverse the effects of aging in mice using an approach that restores communication between a cell’s mitochondria and nucleus.

MitochondriaMitochondria are the power supply for a cell, generating the energy required for key biological functions. When communication breaks down between mitochondria and the cell’s control center (the nucleus), the effects of aging accelerate. Led by David Sinclair, a professor from UNSW Medicine at Harvard Medical School, the team found that by restoring this molecular communication, aging could not only be slowed, but reversed.

Responsible for this breakdown is a decline of the chemical Nicotinamide Adenine Dinucleotide (or NAD). By increasing amounts of a compound used by the cell to produce NAD, Professor Sinclair found that he and his team could quickly repair mitochondrial function. Key indicators of aging, such as insulin resistance, inflammation and muscle wasting, showed extensive improvement.

labmiceIn fact, the researchers found that the tissue of two-year-old mice given the NAD-producing compound for just one week resembled that of six-month-old mice. They said that this is comparable to a 60-year-old human converting to a 20-year-old in these specific areas. As Dr Nigel Turner, an ARC Future Fellow from UNSW’s Department of Pharmacology and co-author of the team’s research paper, said:

It was shocking how quickly it happened. If the compound is administered early enough in the aging process, in just a week, the muscles of the older mice were indistinguishable from the younger animals.

The technique has implications for treating cancer, type 2 diabetes, muscle wasting, inflammatory and mitochondrial diseases as well as anti-aging. Sinclair and his team are now looking at the longer-term outcomes of the NAD-producing compound in mice and how it affects them as a whole. And with the researchers hoping to begin human clinical trials in 2014, some major medical breakthroughs could be just around the corner.

carmat_artificialheartIn another interesting medical story, back in mid-December, a 75 year-old man in Paris became the  recipient of the world’s first Carmat bioprosthetic artificial heart. Now technically, artificial hearts have been in use since the 1980’s. But what sets this particular heart apart, according to its inventor – cardiac surgeon Alain Carpentier – is the Carmat is the first artificial heart to be self-regulating.

In this case, self-regulating refers to the Carmat’s ability to speed or slow its flow rate based on the patient’s physiological needs. For example, if they’re performing a vigorous physical activity, the heart will respond by beating faster. This is made possible via “multiple miniature embedded sensors” and proprietary algorithms running on its integrated microprocessor. Power comes from an external lithium-ion battery pack worn by the patient, and a fuel cell is in the works.

carmat_2Most other artificial hearts beat at a constant unchanging rate, which means that patients either have to avoid too much activity, or risk becoming exhausted quickly. In the course of its human trials, it will be judged based on its ability to keep patients with heart failure alive for a month, but the final version is being designed to operate for five years.

The current lone recipient is reported to be recuperating in intensive care at Paris’ Georges Pompidou European Hospital, where he is awake and carrying on conversations. “We are delighted with this first implant, although it is premature to draw conclusions given that a single implant has been performed and that we are in the early postoperative phase,” says Carmat CEO Marcello Conviti.

medical-technologyAccording to a Reuters report, although the Carmat is similar in size to a natural adult human heart, it’s is somewhat larger and almost three times as heavy – weighing in at approximately 900 grams (2 lb). It should therefore fit inside 86 percent of men, but only 20 percent of women. That said, the company has stated that a smaller model could be made in time.

In the meantime, it’s still a matter of making sure the self-regulating bioprosthetic actually works and prolongs the life of patients who are in the final stages of heart failure. Assuming the trials go well, the Carmat is expected to be available within the European Union by early 2015, priced at between 140,000 and 180,000 euros, which works out to $190,000 – $250,000 US.

See what I mean? From anti-aging to artificial organs, the war on death proceeds apace. Some will naturally wonder if that’s a war meant to be fought, or an inevitably worth mitigating. Good questions, and one’s which we can expect to address at length as the 21st century progresses…

Sources: gizmodo.com, newsroom.unsw.edu.au, (2), carmatsa.com, reuters.com